Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 AlteredExpression BEFREE Serum IGFBP-3 levels in CRC were lower than those of controls (4.68 [3.56, 5.77] vs 5.44 [4.77, 6.10] µg/mL, P < 0.05). 31218761

2019

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE However, IGFBP3 rs2854746 C>G is considered the susceptible CRC polymorphism and IGF1 rs35767 C>T is CRC protective. 30334445

2018

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE Higher IGFBP3 predicted increased incidence of colorectal cancer in older men independent of conventional risk factors and total IGF1. 29044573

2018

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE In conclusion, we revealed that miR‑197 modulates IGFBP3 and therefore plays a critical role in regulating CRC migration and invasion. 30106114

2018

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE Six SNPs in the INS, IGF-I, and IGFBP3 genes were associated with CRC risk, and those associations differed between non-obese/active and obese/inactive women and between E nonusers and users. 29023587

2017

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 PosttranslationalModification BEFREE IGFBP-3 methylation of DNA from 115 PTs and 1641 LNs in patients with stage II CRC from 2 independent cohorts was analyzed. 25822686

2016

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE However, no statistically significant association was noted between IGFBP-3 A-202C polymorphism and colorectal cancer risk. 25966104

2015

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE Given the role of insulin resistance in colorectal cancer (CRC), we explored whether genetic variants in insulin (INS), insulin receptor (INSR), insulin receptor substrate 1 (IRS1), insulin receptor substrate 2 (IRS2), insulin-like growth factor 1 (IGF1), and insulin-like growth factor binding protein 3 (IGFBP3) genes were associated with CRC risk. 25557790

2015

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE Our data also revealed that IGFBP3 hypermethylation may serve as an independent prognostic and predictive biomarker in stage II and III CRC patients. 25127039

2014

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE This meta-analysis demonstrates that there is no association of IGFBP-3 gene rs2854744 and rs2854746 polymorphisms with CRC risk. 24464126

2014

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE The results suggest that the IGFBP3 A-202C and Gly32Ala polymorphisms are not associated with colorectal cancer susceptibility. 23527244

2013

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE Expression of ADAM28 and IGFBP-3 genes in patients with colorectal cancer - a preliminary report. 23527725

2013

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE The associations of four single nucleotide polymorphisms (SNPs) in IGF-I (rs6214), IGFBP-3 (rs3110697), INSR (rs1052371), and IRS2 (rs2289046) genes with the risk of CRC were evaluated using a case-control design with 167 CRC cases and 277 controls by the PCR-RFLP method. 24175768

2013

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE Our experiments on silencing IGFBP3 or IGFBP7 in the two human CRC cell lines SW480, Caco2, and in the rat CRC cell line CC531 show reduced proliferation, colony formation, and for IGFBP3, also reduced migration. 21525788

2011

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker CTD_human Genomic and epigenomic integration identifies a prognostic signature in colon cancer. 21278247

2011

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE The purpose of this study was to examine the association of genetic variants in IGF1 (rs6214, rs6220, and rs35767) and IGFBP3 (rs2854744 and rs2854746) with risk of colorectal polyps and colorectal cancer. 19784788

2010

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE A number of the proteins in these smaller subnetworks have been associated with the progression (CSNK2A2, PLK1, and IGFBP3) or metastatic potential (PDGFRB) of CRC. 19098285

2009

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE Data suggest that the exon 1 G2133C missense variant of IGFBP3 may be a susceptibility factor for colorectal cancer in Chinese subjects. 19492232

2009

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 PosttranslationalModification BEFREE IGFBP-3 methylation was detected in 6 of 13 (46%) and 16 of 24 (67%) GC cell lines and tumors, respectively; 4 of 8 (50%) and 15 of 26 (58%) CRC cell lines and tumors, respectively; 3 of 11 (27%) and 7 of 39 (18%) BC cell lines and tumors, respectively and 1 of 5 (20%) and 18 of 56 (32%) MM cell lines and tumors, respectively. 17096329

2007

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 PosttranslationalModification BEFREE In conclusion, IGFBP3 methylation is inversely associated with MSI in CIMP-high colorectal cancers, and this relationship is limited to p53-negative tumors. 18084616

2007

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE We did not find any association between the CA repeat length or any of the SNPs in the IGF1 and the IGFBP3 genes and the risk of CRC. 18031946

2007

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE Although we were able to confirm this genotype-phenotype association, the -202A/C IGFBP3 SNP was not significantly associated with colorectal cancer risk. 15668488

2005

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 GeneticVariation BEFREE IGFBP-3 genotype was also a significant effect modifier of the relationship between risk factors and colorectal cancer: The positive association between BMI and colorectal cancer was observed only among men (P(interaction) < 0.01) and women (P(interaction) = 0.06) with the GG genotype; the inverse association between postmenopausal hormone use and colorectal cancer was observed only among women with the GG genotype (P = 0.01) and the inverse association between physical activity and colorectal cancer was observed only among men who carried the C allele (P < 0.01). 15894673

2005

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 AlteredExpression BEFREE We evaluated the association of polymorphisms in IGF-1 and IGFBP-3 and circulating levels of IGF-1 and IGFBP-3 in 323 population-based control subjects enrolled in a case-control study of colorectal cancer from September 1999 through February 2002. 15941947

2005

Entrez Id: 3486
Gene Symbol: IGFBP3
IGFBP3
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.600 Biomarker BEFREE IGF-binding protein-3 (IGFBP-3) has been reported to exert a protective influence on the pathogenesis of colorectal cancer. 16322329

2005