Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE The methylation specific PCR (MSP) assay was used for determining the methylation status of CpG island of p16 and MGMT genes in CRC patients. 31004929

2019

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 AlteredExpression BEFREE Somatic epigenetic inactivation of the DNA repair protein O6-methylguanine DNA methyltransferase (MGMT) is frequent in colorectal cancer (CRC); however, its involvement in CRC predisposition remains unexplored. 30677446

2019

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 GeneticVariation BEFREE The impact of the common functional polymorphism of the catechol-O-methyltransferase (COMT) gene, Val158Met, on promoter hypermethylation of P16 and MGMT genes in CRC was also investigated. 30379684

2019

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 GeneticVariation BEFREE The methylation frequencies of MGMT gene promoter were 41.4%, 34.2%, and 44.2% in stomach, esophageal, and colorectal cancer cases while as 16.6, 13.3, and 13.3 in respective controls. 28135856

2017

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 PosttranslationalModification BEFREE This was a multicentre, phase 2 trial, planned according to a two-stage Simon's optimal design to investigate activity and safety of temozolomide in refractory CRC harbouring MGMT promoter methylation. 28427088

2017

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Hierarchical clustering isolated three relevant clusters: (i) cluster of microsatellite stable mucinous adenocarcinomas (54%) with KRAS mutation, and frequent MGMT changes, more frequently located in the left colon, often associated with contiguous precursor adenoma; (ii) cluster of BRAF-mutated mucinous adenocarcinomas (28%) with either microsatellite instability-high or microsatellite stable status, occurring in elderly female patients, nearly all located in the right colon, having the signature of serrated pathway of carcinomas; and (iii) a heterogeneous cluster of microsatellite instability-high mucinous carcinomas (18%), including inherited colorectal carcinomas, displaying a high-grade histological pattern. 28429715

2017

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE The rate of MGMT protein loss was low in metastatic CRC patients from China, and MGMT might be more commonly lost in signet ring cell carcinoma. 27006309

2016

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 PosttranslationalModification BEFREE Secreted frizzled related protein 2 (SFRP2), APC1A in WNT signaling pathway and the DNA repair gene, O6-methylguanine-DNA methyltransferase (MGMT), are frequently hypermethylated in colorectal cancer. 27221916

2016

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 GeneticVariation BEFREE We provide evidence that rs16906252C>T is associated with elevated risk for MGMT-methylated colorectal cancer, likely mediated by constitutive epigenetic repression of the T allele. 27267851

2016

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 PosttranslationalModification BEFREE MGMT promoter in CRC patients was more frequently methylated than in adenoma patients. 25596081

2015

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 PosttranslationalModification BEFREE MGMT hypermethylation is found to be significantly higher in CRC than in normal colorectal mucosa, the pooled OR from 13 studies including 1085 CRC and 899 normal colorectal mucosa, OR = 6.04, 95 % confidence interval (CI) = 4.69-7.77, p < 0.00001. 25716203

2015

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Somatic hypermethylation of the O6-methylguanine-DNA methyltransferase gene (MGMT) was previously associated with G > A transition mutations in KRAS and TP53 in colorectal cancer (CRC). 25638164

2015

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 PosttranslationalModification BEFREE MGMT promoter methylation status in brain metastases from colorectal cancer and corresponding primary tumors. 25832877

2015

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 GeneticVariation BEFREE The advanced stage patients with p16, hMLH1, and MGMT methylation were associated with higher risk of CRC recurrence compared with the local stage patients with unmethylation status in tumor tissues, with adjusted hazard ratios (HRs) (95% confidence interval [CI]) of 9.64 (2.92-31.81), 8.29 (3.40-20.22), and 11.83 (3.49-40.12), respectively. 25815725

2015

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE We applied artificial neural networks (ANNs) to understand the connections among polymorphisms of genes involved in folate metabolism, clinico-pathological features and promoter methylation levels of MLH1, APC, CDKN2A(INK4A), MGMT and RASSF1A in 83 sporadic colorectal cancer (CRC) tissues, and to link dietary and lifestyle factors with gene promoter methylation. 25942531

2015

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE The aim of our study was to evaluate the activity of temozolomide in terms of response rate in patients with metastatic CRC and MGMT methylation, after failure of approved treatments. 24379162

2014

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 GeneticVariation BEFREE In conclusion, this meta-analysis suggests that the PARP-1 rs1136410: T > C polymorphism is a susceptibility factor for GI cancers, but the variant allele of MGMT rs12917: C > T polymorphism appears to be a protective factor for colorectal cancer. 24203816

2014

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 GeneticVariation BEFREE Alterations in MGMT play a critical role in the development of several types of cancer, including glioblastoma, lung cancer, and colorectal cancer. 24801985

2014

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE The objective of this study was to determine the prognostic value of CD133 and MGMT and their possible interaction in colorectal cancer patients. 25015560

2014

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE Alkylating agents, such as dacarbazine, exert their antitumor activity by DNA methylation at the O(6)-guanine site, inducing base pair mismatch; therefore, activity of dacarbazine could be enhanced in CRCs lacking MGMT. 23422094

2013

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 PosttranslationalModification BEFREE Nineteen percent of the screened population (137/740) had confirmed tissue and/or serum MGMT promoter methylation, including 25% (57 of 229) for CRC, 36% (55 of 154) for esophageal cancer, 11% (12 of 113) for head and neck cancer, and 5% (13 of 242) for non-small cell lung carcinoma. 23443801

2013

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 PosttranslationalModification BEFREE To identify which CpG sites are critical for its downregulation, we analyzed the methylation status of the MGMT gene promoter in two sites in CRC patients. 23271133

2013

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE In line with these studies, MGMT was linked to the formation of human sporadic CRC. 23929436

2013

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 Biomarker BEFREE O(6)-CMG is therefore an MGMT substrate, and hence MGMT is likely to be a protective factor in CRC under conditions where O(6)-CMG is a potential causative agent. 23335782

2013

Entrez Id: 4255
Gene Symbol: MGMT
MGMT
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.100 PosttranslationalModification BEFREE This study evaluated the role of Kras gene mutation and RASSF1A, FHIT and MGMT gene promoter hypermethylation together/independently in sporadic CRC in Indian population and correlation with clinicopathological variables of the disease. 23573237

2013