Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.350 AlteredExpression BEFREE WRN mRNA and WRN protein expression levels were low in colorectal cancer cell lines and in primary colorectal cancer and were largely independent of WRN methylation status. 27121793

2016
Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.350 GeneticVariation BEFREE WRN Cys1367Arg variants carriers showed an increased susceptibility for CRC. 25355595

2015
Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.350 GeneticVariation BEFREE This is the first study to analyze the associations between polymorphisms in WRN, BLM and RMI1 and CRC risk. 19945966

2010
Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.350 PosttranslationalModification BEFREE Utilizing 903 population-based colorectal cancers and real-time PCR (MethyLight), we quantified DNA methylation in WRN and eight other promoters (CACNA1G, CDKN2A, CRABP1, IGF2, MLH1, NEUROG1, RUNX3 and SOCS1) known to be specific for CIMP. 18084250

2008
Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.350 Biomarker BEFREE Utilizing real-time polymerase chain reaction (PCR; MethyLight technology), we quantified DNA methylation in 13 CpG island loci (CACNA1G, CDKN2A, CRABP1, IGF2, MLH1, NEUROG1, RUNX3, SOCS1, MINT1, MINT31, IGFBP3, MGMT, and WRN) in 30 metastatic microsatellite stable colorectal carcinomas in phase I/II clinical trials of combination chemotherapy (5-fluorouracil, irinotecan, leucovorin, and gefitinib). 17372756

2007
Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.350 GeneticVariation UNIPROT