Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011206
Disease: Delirium
Delirium
0.400 AlteredExpression BEFREE After adjusting for age, gender, Acute Physiology and Chronic Health Evaluation II score, Charlson comorbidity score, sepsis diagnosis and study intervention group, interleukin-6, -8, and -10, tumor necrosis factor-α, C-reactive protein, and S-100β levels in quartile 4 were negatively associated with delirium-/coma-free days by 1 week and 30 days post enrollment. 31770149

2020

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0011206
Disease: Delirium
Delirium
0.400 Biomarker BEFREE We tested whether APOE modifies the established association between C-reactive protein (CRP) and delirium incidence, severity, and duration in 553 noncardiac surgical patients aged 70 and older. 31761478

2020

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011206
Disease: Delirium
Delirium
0.400 Biomarker BEFREE We aimed to develop a multi-protein signature of delirium by identifying proteins associated with delirium from unbiased proteomics and combining them with delirium biomarkers identified in our prior work (interleukin [IL]-6 and IL-2). 29529166

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011206
Disease: Delirium
Delirium
0.400 Biomarker BEFREE Change in Serum Level of Interleukin 6 and Delirium After Coronary Artery Bypass Graft. 31676521

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011206
Disease: Delirium
Delirium
0.400 AlteredExpression BEFREE Patients with delirium had higher plasma levels of IL-6 compared to those without; 138.3 pg/mL [28.0-296.7] vs 53.6 pg/mL [109.3-505, P = 0.050]. 30079511

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011206
Disease: Delirium
Delirium
0.400 AlteredExpression BEFREE The reduced incidence and duration of delirium by dexmedetomidine was associated with reduced levels of IL-6 24 h after surgery. 29549829

2018

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011206
Disease: Delirium
Delirium
0.400 AlteredExpression BEFREE The plasma IL-6 level was higher in delirious patients compared to patients without delirium. 29669581

2018

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0011206
Disease: Delirium
Delirium
0.400 GeneticVariation BEFREE The presence of an APOE ε4 allele was also associated with greater delirium severity averaged across the PAC stay. 27122004

2017

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011206
Disease: Delirium
Delirium
0.400 Biomarker BEFREE The main exposure was IL-6 concentration (pg/ml) from blood sampled at three time points before delirium occurred. 28587598

2017

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0011206
Disease: Delirium
Delirium
0.400 Biomarker BEFREE This study tests the hypothesis that the quantification of brain vulnerability, using Apolipoprotein E (ApoE) status and neuropsychological tests, both traditional and more easily administered, can quantify the risk of post-operative delirium following elective primary arthroplasty surgery. 28383643

2017

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0011206
Disease: Delirium
Delirium
0.400 Biomarker BEFREE Ten papers were found that examined the relationship between APOE and delirium. 26901792

2016

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0011206
Disease: Delirium
Delirium
0.400 Biomarker BEFREE No association between ApoE and delirium severity or number of delirium days was observed. 26238230

2015

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011206
Disease: Delirium
Delirium
0.400 AlteredExpression BEFREE Additionally, 77% had delirium or coma (acute brain dysfunction), and compared with other patients, had fewer ventilator-free days (P = .03), longer stay (P = .04), higher care needs at discharge (P = .001), higher mortality (P = .02), and higher levels of interleukin 6 (P = .03), and the APOE*3/*3 apolipoprotein E genotype (P = .05). 24382617

2014

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011206
Disease: Delirium
Delirium
0.400 Biomarker PSYGENET Additionally, 77% had delirium or coma (acute brain dysfunction), and compared with other patients, had fewer ventilator-free days (P = .03), longer stay (P = .04), higher care needs at discharge (P = .001), higher mortality (P = .02), and higher levels of interleukin 6 (P = .03), and the APOE*3/*3 apolipoprotein E genotype (P = .05). 24382617

2014

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0011206
Disease: Delirium
Delirium
0.400 Biomarker PSYGENET Additionally, 77% had delirium or coma (acute brain dysfunction), and compared with other patients, had fewer ventilator-free days (P = .03), longer stay (P = .04), higher care needs at discharge (P = .001), higher mortality (P = .02), and higher levels of interleukin 6 (P = .03), and the APOE*3/*3 apolipoprotein E genotype (P = .05). 24382617

2014

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0011206
Disease: Delirium
Delirium
0.400 AlteredExpression BEFREE Additionally, 77% had delirium or coma (acute brain dysfunction), and compared with other patients, had fewer ventilator-free days (P = .03), longer stay (P = .04), higher care needs at discharge (P = .001), higher mortality (P = .02), and higher levels of interleukin 6 (P = .03), and the APOE*3/*3 apolipoprotein E genotype (P = .05). 24382617

2014

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011206
Disease: Delirium
Delirium
0.400 AlteredExpression BEFREE In patients with only coma (n=15), only delirium (n=7), and neither ever (n=14), we measured plasma levels of tumor necrosis factor-α, interleukin (IL)-1β, IL-1RA, IL-6, IL-8, IL-10, IL-17,macrophage inflammatory protein-1β, and monocyte chemotactic protein-1. 23385102

2013

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011206
Disease: Delirium
Delirium
0.400 Biomarker PSYGENET In patients with only coma (n=15), only delirium (n=7), and neither ever (n=14), we measured plasma levels of tumor necrosis factor-α, interleukin (IL)-1β, IL-1RA, IL-6, IL-8, IL-10, IL-17,macrophage inflammatory protein-1β, and monocyte chemotactic protein-1. 23385102

2013

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0011206
Disease: Delirium
Delirium
0.400 Biomarker PSYGENET There was no association between the presence of an APOEε4 allele and the occurrence of delirium in the acute phase after stroke. 23969090

2013

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0011206
Disease: Delirium
Delirium
0.400 GeneticVariation BEFREE There was no association between the presence of an APOEε4 allele and the occurrence of delirium in the acute phase after stroke. 23969090

2013

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011206
Disease: Delirium
Delirium
0.400 GeneticVariation BEFREE Genetic variations in the interleukin-6 and interleukin-8 genes and the interleukin-6 receptor gene in delirium. 21851175

2011

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011206
Disease: Delirium
Delirium
0.400 Biomarker PSYGENET On, multivariate analysis, BI was significantly affected by MMSE, APOE, IL-1α, IL-6, LIF and TNF-α levels (p<0.05) but not by delirium. 20471115

2011

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0011206
Disease: Delirium
Delirium
0.400 Biomarker PSYGENET On, multivariate analysis, BI was significantly affected by MMSE, APOE, IL-1α, IL-6, LIF and TNF-α levels (p<0.05) but not by delirium. 20471115

2011

Entrez Id: 348
Gene Symbol: APOE
APOE
CUI: C0011206
Disease: Delirium
Delirium
0.400 Biomarker PSYGENET Apolipoprotein E-ε4 genotype was not associated with either delirium or POCD following adjustment for covariates. 21222188

2011

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0011206
Disease: Delirium
Delirium
0.400 Biomarker PSYGENET Rs1800697 and rs1800797 in the IL6 gene, rs8192284 in the IL6R gene, and rs4073 in the IL8 gene were not associated with the development of delirium. 21851175

2011