Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.470 Biomarker BEFREE Genetic polymorphisms of 4 genes, methylenetetrahydrofolate reductase (MTHFR) and apolipoprotein E (ApoE) have been demonstrated to associate with the increased risk for both MDD and stroke, while the association between identified polymorphisms in angiotensin converting enzyme (ACE) and serum paraoxonase (PON1) with depression is still under debate, for the existing studies are insufficient in sample size. 30898617

2019

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.470 GeneticVariation BEFREE Lowered PON1 activities are strongly associated with depression and bipolar disorder, recurrence of (hypo)mania and depression, increased disability and lowered quality of life. 28441923

2019

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.470 Biomarker BEFREE Changes in the concentration levels of GR, IL-18, PON-1, and OxLDL may constitute a biological response to oxidative stress typical of depression. 28623707

2017

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.470 AlteredExpression BEFREE The results suggest that lowered plasma PON1 activity is a trait marker of major depression and that PONQ192R gene-environment (smoking) interactions differentially predict the odds of depression and bipolar disorder. 24679385

2014

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.470 AlteredExpression BEFREE Workers had significantly inhibited AChE and BuChE after CPF application; however, neither CPOase activity nor POase activity was associated with ChE depression when adjusted for CPF exposure (as determined by urinary TCPy levels) and stratified by PON1 genotype. 22975224

2012

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.470 GeneticVariation BEFREE We aimed to examine associations between the PON1 Q192R polymorphism and self-reported poor health and depression in two independent population-based studies. 19651761

2009

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.470 Biomarker CTD_human Decreased PON1 and ghrelin levels as well as fluctuations in lipid profiles may be involved in the etiology of depressive disorders. 19272368

2009

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.470 GeneticVariation BEFREE The R allele of PON1 Q192R was associated with depression: per-allele odds ratio 1.22 (95% confidence interval: 1.05 to 1.41) in this population. 17183021

2007

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.470 Biomarker HPO