Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker BEFREE The PC-1 gene has been associated with dyslipidemia, polycystic ovarian disease and T2DM in different regions of the world. 31250990

2019

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Association and in silico studies of ENPP1 gene variants with type 2 diabetes mellitus in a Northern Iranian population. 29958952

2018

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE In this study, association of K121Q (rs1044498) polymorphism of the ENPP1 gene with T2DM and bone disorders is evaluated. 28942038

2017

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE The association of the two polymorphisms of ENPP1 (rs7754586 and rs55725924) with T2D and diabetes-related quantitative traits was analyzed in Chinese samples containing 929 T2D patients and 1044 healthy individuals. 28951309

2017

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE We investigated the association of ENPP1 121Q variant with coronary artery disease (CAD) in patients with and without T2DM in South Indian population. 28497367

2017

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE We conducted an exploratory analysis by testing whether common genetic variability at IRS1, ENPP1 and TRIB3 loci is associated with cardiovascular risk traits and metabolic phenotypes in T2DM. 26868433

2016

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Our study indicates that the ENPP1 rs1044498 SNP is associated with T2D, waist circumference, and fasting glucose in Taiwanese subjects. 27238374

2016

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker BEFREE Here, we identified microRNA-27b (miR-27b) as a key regulator for the generation of a side-population in breast cancer cells that showed CSC properties, and also found that the anti-type II diabetes (T2D) drug metformin reduced this side-population via miR-27b-mediated repression of ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1), which is involved in T2D development. 26065921

2015

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE For the overall population, there was a significant association between ENPP1 gene polymorphisms and T2D when comparing the Q allele versus K allele (OR = 1.29, 95% CI 1.16-1.44, p = 0.000). 25109753

2014

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Ectoenzyme nucleotide pyrophosphate phosphodiesterase 1 (ENPP1) gene has been studied in relation to type 2 diabetes mellitus (T2DM) and insulin resistance (IR). 25368487

2014

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 AlteredExpression BEFREE Liver ENPP1 expression in T2DM is the reverse of that expected based on expression in other tissues and is likely due to the unique role the liver has in insulin clearance. 25539584

2014

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker BEFREE We report the genetic variants in five candidate genes: TCF7L2, HHEX, ENPP1, IDE and FTO, are significantly associated (after Bonferroni correction, p<5.5E-04) with T2D susceptibility in combined population. 23527042

2013

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker BEFREE We found that highly-interconnected T2D disease network "hub" genes most highly associated to T2D genetic risks to be PI3KR1, ESR1, and ENPP1. 23281828

2012

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Under an additive genetic model, the C allele of ADRB3-rs4994, the C allele of ENPP1-rs1044498, and the A allele of PPARGC1A-rs8192678 increase the risk of type 2 diabetes in the Chinese Han population. 22391941

2012

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker BEFREE These findings are concordant with the AdiposeENPP1-Tg phenotype and identify a potential target of therapy for health complications of AT dysfunction, including type 2 diabetes and cardiovascular disease. 23012391

2012

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Despite the similarities founded in a number of loci, the Woolf test reported that the contributions of ENPP1 and ACE loci in T2D risk are dependent on the geographic origin of concerned groups, and this heterogeneity could be attributed not only to the variable contribution of the variant in T2D risk but also to diversities of genetic background between tested groups. 23249316

2012

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Compared to the carrier of the AA genotype of the ENPP1 rs1044498 polymorphism, the likelihood of T2D was 2.442 (95% confidence interval, 1.592-3.747) for the carrier of combined AC+CC genotypes after adjustment of sex and body mass index. 23111648

2012

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE There was a significant association between ENPP1 K121Q gene polymorphism and T2D in the Chinese population (P = .003). 22136912

2012

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker BEFREE The gene encoding ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) is a candidate susceptibility gene for obesity and type 2 diabetes. 21198320

2011

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Our study did not replicate the positive association found previously and suggested that K121Q of ENPP1 might not have a major role in the susceptibility to T2D or obesity in the Chinese Han population. 20981035

2011

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE We studied the association of the ENPP1 K121Q polymorphism with type 2 diabetes (T2D) in 639 unrelated patients and 885 control subjects with normal glucose tolerance of northern China. 21452007

2011

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Our results suggest that the ENPP1 121Q allele might not be associated with T2D and related metabolic traits among Iranian subjects. 21153685

2011

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE To evaluate the association between the K121Q polymorphism of the ENPP1 gene and IHD in white patients with type 2 diabetes mellitus (DM). 20428609

2010

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Our study demonstrates that the ENPP1 K121Q and MMP3 -709A>G polymorphisms are associated with T2D, and that the ENPP1 Q allele is associated with increased aortic arch calcification in a Korean population. 20092902

2010

Entrez Id: 5167
Gene Symbol: ENPP1
ENPP1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE The objective of this study was to investigate the possible role of K121Q polymorphism in ENPP1 gene with type 2 diabetes in North Indians. 20820885

2010