×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
GWASCAT
Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population.
30718926
2019
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
BEFREE
CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1 ) is a tRNA-modifying enzyme that catalyzes 2-methylthiolation (ms<sup>2</sup>) and has been implicated in the development of type 2 diabetes (T2D ).
31189758
2019
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
GWASCAT
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
30595370
2019
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
GWASCAT
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls.
31118516
2019
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
BEFREE
Moreover, the contribution of CDKAL1 polymorphisms to T2D risk seems to be associated with age, gender, BMI, smoking and drinking.
31639799
2019
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
BEFREE
However, no significant association was detected between HHEX (rs1111875 ), CDKAL1 (rs7756992 ), or UBE2E2 (rs7612463 ) and T2D .
29871606
2018
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
BEFREE
Intronic polymorphisms in CDKAL1 , a tRNA methylthiotransferase, are associated with increased type 2 diabetes risk.
30247717
2018
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
GWASCAT
Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes.
30054458
2018
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
GWASCAT
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes.
29358691
2018
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
BEFREE
Body mass index modulates the association between CDKAL1 rs10946398 variant and type 2 diabetes among Taiwanese women.
30185902
2018
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
GWASCAT
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
28869590
2017
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
BEFREE
CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes .
28821857
2017
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
GWASCAT
Interaction of iron status with single nucleotide polymorphisms on incidence of type 2 diabetes.
28406950
2017
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
BEFREE
These results suggest that the type 2 diabetes susceptibility gene CDKAL1 has novel functions in regulating mitochondrial activity.
29031721
2017
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
BEFREE
The analysis of the frequency distribution of polymorphic markers for genes <i>KCNJ11, CDKAL1 , SLC30A8</i> and <i>CDKN2B</i> showed statistically significant associations with T2DM in the Russian population.
28717589
2017
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
BEFREE
Analyzing data from 113 203 non-diabetic UK Biobank participants, we observed three (near TCF7L2, CDKN2AB and CDKAL1 ) overestimated (body mass index (BMI) decreasing) and one (near MTNR1B) underestimated (BMI increasing) associations among 11 type 2 diabetes risk alleles (at P < 0.05).
28040731
2017
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
BEFREE
Our results identify CDKAL1 as novel negative regulator of adipocyte differentiation and provide insights into the link between CDKAL1 and metabolic diseases such as type 2 diabetes and obesity.
28779110
2017
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
BEFREE
Application of MR-MEGA to fine-mapping four type 2 diabetes susceptibility loci in 22,086 cases and 42,539 controls highlights: (i) strong evidence for heterogeneity in allelic effects that is correlated with ancestry only at the index SNP for the association signal at the CDKAL1 locus; and (ii) 99% credible sets with six or fewer variants for five distinct association signals.
28911207
2017
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
BEFREE
A total of 3 SNPs [rs9465871 (CDKAL1 ), rs10761745 (JMJD1C), and rs163177 (KCNQ1)] were selected as candidate SNPs related to T2D .
28406950
2017
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
BEFREE
CONCLUSIONS Polymorphisms in CDKN2A/2B and FTO, but not CDKAL1 , may be associated with T2D , and alleles rs8050136 and rs9939609 are likely risk alleles for T2D in this population.
26873362
2016
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
Biomarker
BEFREE
A significant association was seen of all the three SNPs of CDKAL1 and CDKN2A/B genes with T2DM but none of the two SNPs of HHEX.
27377502
2016
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
BEFREE
For type 2 diabetes , we detected a recessive effect (p DOMDEV = 5 × 10(-4)) at CDKAL1 .
26961502
2016
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
GWASCAT
Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility.
27189021
2016
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
GWASCAT
Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes.
26818947
2016
×
Entrez Id:
54901
Gene Symbol:
CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700
GeneticVariation
GWASCAT
Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.
26961502
2016