Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Identification of 28 new susceptibility loci for type 2 diabetes in the Japanese population. 30718926

2019

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker BEFREE CDK5 regulatory subunit associated protein 1-like 1 (CDKAL1) is a tRNA-modifying enzyme that catalyzes 2-methylthiolation (ms<sup>2</sup>) and has been implicated in the development of type 2 diabetes (T2D). 31189758

2019

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370

2019

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. 31118516

2019

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Moreover, the contribution of CDKAL1 polymorphisms to T2D risk seems to be associated with age, gender, BMI, smoking and drinking. 31639799

2019

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE However, no significant association was detected between HHEX (rs1111875), CDKAL1 (rs7756992), or UBE2E2 (rs7612463) and T2D. 29871606

2018

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Intronic polymorphisms in CDKAL1, a tRNA methylthiotransferase, are associated with increased type 2 diabetes risk. 30247717

2018

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. 30054458

2018

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes. 29358691

2018

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Body mass index modulates the association between CDKAL1 rs10946398 variant and type 2 diabetes among Taiwanese women. 30185902

2018

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease. 28869590

2017

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes. 28821857

2017

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Interaction of iron status with single nucleotide polymorphisms on incidence of type 2 diabetes. 28406950

2017

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker BEFREE These results suggest that the type 2 diabetes susceptibility gene CDKAL1 has novel functions in regulating mitochondrial activity. 29031721

2017

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker BEFREE The analysis of the frequency distribution of polymorphic markers for genes <i>KCNJ11, CDKAL1, SLC30A8</i> and <i>CDKN2B</i> showed statistically significant associations with T2DM in the Russian population. 28717589

2017

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Analyzing data from 113 203 non-diabetic UK Biobank participants, we observed three (near TCF7L2, CDKN2AB and CDKAL1) overestimated (body mass index (BMI) decreasing) and one (near MTNR1B) underestimated (BMI increasing) associations among 11 type 2 diabetes risk alleles (at P  <  0.05). 28040731

2017

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker BEFREE Our results identify CDKAL1 as novel negative regulator of adipocyte differentiation and provide insights into the link between CDKAL1 and metabolic diseases such as type 2 diabetes and obesity. 28779110

2017

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Application of MR-MEGA to fine-mapping four type 2 diabetes susceptibility loci in 22,086 cases and 42,539 controls highlights: (i) strong evidence for heterogeneity in allelic effects that is correlated with ancestry only at the index SNP for the association signal at the CDKAL1 locus; and (ii) 99% credible sets with six or fewer variants for five distinct association signals. 28911207

2017

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE A total of 3 SNPs [rs9465871 (CDKAL1), rs10761745 (JMJD1C), and rs163177 (KCNQ1)] were selected as candidate SNPs related to T2D. 28406950

2017

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE CONCLUSIONS Polymorphisms in CDKN2A/2B and FTO, but not CDKAL1, may be associated with T2D, and alleles rs8050136 and rs9939609 are likely risk alleles for T2D in this population. 26873362

2016

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker BEFREE A significant association was seen of all the three SNPs of CDKAL1 and CDKN2A/B genes with T2DM but none of the two SNPs of HHEX. 27377502

2016

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE For type 2 diabetes, we detected a recessive effect (p DOMDEV = 5 × 10(-4)) at CDKAL1. 26961502

2016

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Multi-ethnic genome-wide association study identifies novel locus for type 2 diabetes susceptibility. 27189021

2016

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes. 26818947

2016

Entrez Id: 54901
Gene Symbol: CDKAL1
CDKAL1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively. 26961502

2016