Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5506
Gene Symbol: PPP1R3A
PPP1R3A
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE For the first time, rs1799999 in PPP1R3A was associated with risk of T2D in Mayan Mexican individuals (OR = 1.625, P = 0.014). 29948331

2018

Entrez Id: 5506
Gene Symbol: PPP1R3A
PPP1R3A
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE Polymorphisms were selected on the basis of information available in the literature for INS (rs689), INSR (rs1799816) and PP1G.G (rs1799999) in context to T2D. 26251103

2016

Entrez Id: 5506
Gene Symbol: PPP1R3A
PPP1R3A
Diabetes Mellitus, Non-Insulin-Dependent
1.000 Biomarker BEFREE A 5-bp insertion-deletion polymorphism in the (AU)AT-rich element (ARE) within the 3'-untranslated region of the gene encoding the muscle-specific glycogen-targeting subunit of protein phosphatase 1 (PPP1R3) has been associated with insulin resistance and type 2 diabetes. 15181086

2004

Entrez Id: 5506
Gene Symbol: PPP1R3A
PPP1R3A
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE The ARE2 allele of PPP1R3A is associated with a male preponderance to early diagnosed type 2 diabetes. 12831406

2003

Entrez Id: 5506
Gene Symbol: PPP1R3A
PPP1R3A
Diabetes Mellitus, Non-Insulin-Dependent
1.000 Biomarker MGD Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance. 12606498

2003

Entrez Id: 5506
Gene Symbol: PPP1R3A
PPP1R3A
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE The p85alpha subunit of phosphatidyl inositol 3 kinase (PIK3R1) and the regulatory subunit 3 of protein phosphatase 1 (PPP1R3) were selected as candidate genes because both encode key proteins involved in insulin signalling and because polymorphisms in these genes have been previously implicated in insulin resistance or type II diabetes. 12185156

2002

Entrez Id: 5506
Gene Symbol: PPP1R3A
PPP1R3A
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE The association between PPP1R3 gene polymorphisms and type 2 diabetes mellitus. 11793847

2001

Entrez Id: 5506
Gene Symbol: PPP1R3A
PPP1R3A
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE The aim of this study was to investigate whether two common variants in the PPP1R3 gene, Asp905Tyr and PP1ARE, are associated with reduced insulin sensitivity or can predict the development of impaired glucose tolerance (IGT) or type 2 diabetes during a 20-year follow-up period in 696 50-year-old Caucasian men. 10868947

2000

Entrez Id: 5506
Gene Symbol: PPP1R3A
PPP1R3A
Diabetes Mellitus, Non-Insulin-Dependent
1.000 AlteredExpression BEFREE We suggest that the increased protein binding to ARE2 contributes to a faster degradation of PPP1R3 mRNA carrying this allele, and the resulting lower concentration of the protein contributes to insulin resistance, thus increasing the risk for development of type 2 diabetes. 10479482

1999

Entrez Id: 5506
Gene Symbol: PPP1R3A
PPP1R3A
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE These results indicate that the frequency of polymorphism of the PPP1R3 gene (ARE-2 and Asp905) is different between two ethnic groups and is increased in Japanese people with type 2 diabetes, suggesting that these variants may be a possible marker for searching for diabetogenic genes. 10389856

1999

Entrez Id: 5506
Gene Symbol: PPP1R3A
PPP1R3A
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE These data suggest that the Asp905Tyr polymorphism of the PPP1R3 gene is not associated with NIDDM or high BMI, both of which are known to be insulin-resistant states, in the Japanese population. 9653600

1998

Entrez Id: 5506
Gene Symbol: PPP1R3A
PPP1R3A
Diabetes Mellitus, Non-Insulin-Dependent
1.000 AlteredExpression BEFREE Because of its apparent effect on expression of PPP1R3, it may, in part, contribute to the higher prevalence of type 2 diabetes in this Native American population. 9726244

1998

Entrez Id: 5506
Gene Symbol: PPP1R3A
PPP1R3A
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation BEFREE The carrier prevalence of the PP1G-subunit variant was 18% in 150 healthy subjects and 13% in 313 NIDDM subjects (chi 2 = 1.94, p = 0.16). 7581368

1995

Entrez Id: 5506
Gene Symbol: PPP1R3A
PPP1R3A
Diabetes Mellitus, Non-Insulin-Dependent
1.000 Biomarker BEFREE Because the glycogen-associated regulatory subunit of protein phosphatase 1 (PP1 G-subunit) plays a key role in the insulin stimulation of glycogen synthesis and the activity of PP1 is decreased in insulin-resistant subjects, we have now cloned the human G-subunit cDNA to search for abnormalities in the corresponding gene (designated PPP1R3 in the human genome nomenclature) in patients with NIDDM. 7926294

1994

Entrez Id: 5506
Gene Symbol: PPP1R3A
PPP1R3A
Diabetes Mellitus, Non-Insulin-Dependent
1.000 GeneticVariation UNIPROT Because the glycogen-associated regulatory subunit of protein phosphatase 1 (PP1 G-subunit) plays a key role in the insulin stimulation of glycogen synthesis and the activity of PP1 is decreased in insulin-resistant subjects, we have now cloned the human G-subunit cDNA to search for abnormalities in the corresponding gene (designated PPP1R3 in the human genome nomenclature) in patients with NIDDM. 7926294

1994

Entrez Id: 5506
Gene Symbol: PPP1R3A
PPP1R3A
Diabetes Mellitus, Non-Insulin-Dependent
1.000 Biomarker HPO

Entrez Id: 5506
Gene Symbol: PPP1R3A
PPP1R3A
Diabetes Mellitus, Non-Insulin-Dependent
1.000 Biomarker CTD_human

Entrez Id: 5506
Gene Symbol: PPP1R3A
PPP1R3A
Diabetes Mellitus, Non-Insulin-Dependent
1.000 Biomarker GENOMICS_ENGLAND