Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker BEFREE This study revealed an association of SIRT1 and WFS1 with T2D risk. 31759989

2020

Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370

2019

Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE HHEX, HMGA2, GLIS3, MTNR1B and PARK2) and some overlap with SNPs associated with T2D (e.g. rs3821943 near WFS1 and rs508419 near ANK1). 31123324

2019

Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Genome-wide association analyses identify 143 risk variants and putative regulatory mechanisms for type 2 diabetes. 30054458

2018

Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes. 29632382

2018

Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Identification of a missense variant in the WFS1 gene that causes a mild form of Wolfram syndrome and is associated with risk for type 2 diabetes in Ashkenazi Jewish individuals. 30014265

2018

Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 AlteredExpression BEFREE Altered expression of WFS1 and NOTCH2 genes may play a role in pathogenesis and development of DN in patients with T2DM. 29626590

2018

Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Differential promoter activity by nucleotide substitution at a type 2 diabetes genome-wide association study signal upstream of the wolframin gene. 25800097

2016

Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker BEFREE We examined the effect of interactions between seven incretin-related genetic variants in GIPR, KCNQ1, TCF7L2 and WFS1 and dietary components (whey-containing dairy, cereal fibre, coffee and olive oil) on the risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study. 27623947

2016

Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker GENOMICS_ENGLAND A three-step programmed method for the identification of causative gene mutations of maturity onset diabetes of the young (MODY). 27185633

2016

Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Genetic variants of WFS1, CDKAL1, CDKN2BAS, TCF7L2, HHEX, KCNQ1, TSPAN8/LGR5, FTO, and TCF2 were associated with the risk for T2D with MetS, as well as the risk for development of T2D with at least one of the MetS components (P < 0.05). 26599349

2015

Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Although the connection between loss of function mutations of the WFS1 gene and DIDMOAD-syndrome including diabetes mellitus underpins the significance of wolframin in the pathogenesis, exact role of WFS1 polymorphic variants in the development of type 1 and type 2 diabetes has not been discovered yet. 26426397

2015

Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASDB Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480

2014

Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. 24509480

2014

Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE While FTO rs8050136 and rs17817449, ADAMTS9 rs4607103, and WFS1 rs10010131 were initially associated with T2DM, this was lost upon multiple testing correction. 24145053

2013

Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE The aim of this study was to investigate association of WFS1 genes polymorphisms (rs734312 and rs10010131) with T2D by conducting a meta-analysis. 23257691

2013

Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASDB Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. 23300278

2013

Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE T2D variants were associated with PCOS phenotype parameters including those in THADA and WFS1 with testosterone levels, ENPP/PC1 with triglyceride levels, FTO with glucose levels and KCNJ11 with FSH levels. 22389004

2013

Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 Biomarker BEFREE At six loci with genome-wide evidence for T2D association (AP3S2, KCNK16, NOTCH2, SCL30A8, VPS26A, and WFS1) predicted mRNA target sites for islet-expressed miRNAs overlapped potentially causal variants. 23372846

2013

Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Nine variants in FTO rs8050136, WFS1 rs10010131, CDKN2A/B rs10811661, KCNJ11 rs5219, CDC123/CAMK1D rs12779790, JAZF1 rs864745, SLC30A8 rs13266634, CDKAL1 rs10946398, and HHEX/IDE rs5015480 were significantly associated with T2DM (P < 0.05). 23298195

2013

Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASDB Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922

2012

Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASCAT Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. 22885922

2012

Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. 22325160

2012

Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE Our findings suggest a shared genetic risk for type 2 diabetes and its kidney complications, and a potential role for WFS1 in early-onset diabetic nephropathy in American Indian populations. 22513821

2012

Entrez Id: 7466
Gene Symbol: WFS1
WFS1
Diabetes Mellitus, Non-Insulin-Dependent
0.700 GeneticVariation BEFREE The most frequent haplotype at the haplotype block containing the WFS1 gene modulated insulin secretion and was associated with an increased risk of type 2 diabetes. 21127832

2011