Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE CD133 has reproducibly been shown to correlate with disease progression, recurrence, and poor overall survivorship in the malignant adult brain tumor, glioblastoma (GBM). 31695152

2020

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE Results showed that the IgY-abrin immunotoxin had cytotoxic activity against CD133+ MGSCs and provides a novel approach for the immunotherapy of glioblastoma. 31275378

2019

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE In order to better understand the mechanisms regulating the tumorigenic properties of this population, we studied the role of the polycomb group member BMI1 in our patient-derived GBM BTICs and its relationship with CD133, a well-established marker of BTICs. 31115870

2019

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Moreover, one recent report demonstrated that <i>LIS1</i> gene is preferentially expressed in CD133+ glioblastoma cells and may have also an important role in regulating CD133+ CSC in glioblastoma. 31750243

2019

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE More importantly, the constructed therapeutic <sup>CD133</sup>mAb/TMAMbs have a specifically effective uptake via the CD133 transmembrane protein that is overexpressed in U251 glioblastoma cells and displayed an effective antitumor proliferation and invasive ability. 31573817

2019

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE MTAP deficiency promotes glioma stem-like cell (GSC) formation with increased expression of <i>PROM1</i>/CD133 and enhanced tumorigenicity of GBM cells and is associated with poor prognosis in patients with GBM. 31040154

2019

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Using three glioblastoma cell-lines (U87, U251, and SNB19), the adaptation of glioblastoma cells in a 1% (hypoxia) and 20% (normoxia) oxygen microenvironment on proliferation, metabolism, migration, neurosphere formation, CD133 and VEGF expression was investigated. 31035344

2019

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE Bioinformatics data have indicated that dopamine receptor (DRD) 2, DRD4, CD133 and Nestin were elevated in GBM clinical samples and correlated to Temozolomide (TMZ) resistance and increased aldehyde dehydrogenase (ALDH) activity (3.5-8.9%) as well as enhanced (2.1-2.4-fold) neurosphere formation efficiency in U87MG and D54MG GBM cell lines. 31561595

2019

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Our gene expression analysis of paired cohorts of patients with primary and recurrent GBMs identified a CD133-to-CD109 shift in tumors with an MES recurrence. 30759398

2019

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE We found that the shortened version of the aptamer 40L, which we have called A40s, costained with CD133-labeled cells in human GBM tissue, suggestive of an ability to specifically recognize GSCs in fixed human tissues. 31541799

2019

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE We sorted human glioblastoma T98G and U87MG cells into CD133<sup>+</sup> and CD133<sup>-</sup> pools and measured apoptosis and CD133 expression levels in response to cisplatin treatment. 30267383

2018

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE We reported that WIP knockdown in mtp53-expressing glioblastoma greatly reduced proliferation and growth capacity of cancer stem cell (CSC)-like cells and decreased CSC-like markers, such as hyaluronic acid receptor (CD44), prominin-1 (CD133), yes-associated protein (YAP) and transcriptional co-activator with PDZ-binding motif (TAZ). 29890731

2018

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE We found that the expression of CD133 was upregulated under hypoxic conditions in both the 2D and 3D GBM cell culture models. 29492900

2018

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Dual-targeting immunoliposomes using angiopep-2 and CD133 antibody for glioblastoma stem cells. 29162480

2018

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE A stem cell marker, CD133, was reported to predict recurrence patterns in intracranial glioblastoma. 29180077

2018

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE CD133 Expression in Glioblastoma Multiforme: A Literature Review. 30555755

2018

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE The treatment also elicited (a) suppression of the M2-linked tumor-promoting proteins STAT3, ARG1, and IL10, (b) induction of the M1-linked anti-tumor proteins STAT1 and inducible nitric oxide synthase in the TAM, (c) elimination of CD133(+) GBM stem cells, and (d) activation of caspase3 in the GBM cells. 30041669

2018

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Selective Targeting of CD133-Expressing Glioblastoma Stem Cells Using Lentiviral Vectors. 29392693

2018

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE This chapter describes a straightforward method for isolating glioblastoma stem cells (GSCs) from in vitro tissue cultures via fluorescence-activated cell sorting (FACS) using CD133 as a surface marker. 29392691

2018

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE Immuno-labeling of cathepsins K and X was observed in areas of CD133-positive glioblastoma stem cells, localized around arterioles in their niches that also expressed SDF-1α and CD68. mRNA levels of both cathepsins K and X correlated with mRNA levels of markers of glioblastoma stem cells and their niches. 30367810

2018

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE Furthermore, NAMPT expression correlated with high levels of Nanog, CD133 and CIC-like cells in glioblastoma directly extracted from patients. 29245920

2017

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE WIP knockdown from mtp53-expressing glioblastoma and breast cancer cells (BCC) greatly reduced proliferation and growth capacity of cancer stem cell (CSC)-like cells and decreased CSC-like markers (CD133, CD44 or YAP/TAZ). mtp53 overexpression in human astrocytes enhanced their proliferative capacity in suspension culture and increased expression of CSC markers and WIP. 28166194

2017

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE More importantly, higher CD133 expression is associated with poor prognosis in glioblastoma and breast cancer patients. 28602756

2017

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 AlteredExpression BEFREE Association of glial to mesenchymal transition (GMT)-related molecular with ObR expression and VM formation in glioblastoma tissues indicated that ObR-positive glioblastoma cells with GMT phenotype might be more likely to constitute VM, and co-expression of ObR and CD133 or Nestin to constitute the channel impliated that ObR-positive glioblastoma cells displayed glioblastoma stem cells (GSC) properties. 28938545

2017

Entrez Id: 8842
Gene Symbol: PROM1
PROM1
CUI: C0017636
Disease: Glioblastoma
Glioblastoma
0.400 Biomarker BEFREE CD133+ GSCs express significantly higher ASAH1 compared to CD133- GSCs and serum-cultured glioblastoma cell lines, such as U87MG. 29348854

2017