Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression BEFREE Activation of PTGS2/NF-κB signaling pathway enhances radiation resistance of glioma. 30740906

2019

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE Reprogramming COX-2, mPGES-1 and CYP4A mediated-AA metabolism in glioma by flavonoid ISL inhibits the angiogenic Akt- FGF-2/TGF-β/VEGF signaling through ceRNA effect of miR-194-5p and lncRNA NEAT1, and may serve as a novel therapeutic strategy for human glioma. 31438982

2019

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression BEFREE In the animal experiments, IATL reduced the size and weight of glioma tumors in xenograft mice and inhibited the expression of COX-2 and phosphorylated NF-κB p65 in the transplanted tumors. 30740911

2019

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE The Effect of Biotinylated PAMAM G3 Dendrimers Conjugated with COX-2 Inhibitor (celecoxib) and PPARγ Agonist (Fmoc-L-Leucine) on Human Normal Fibroblasts, Immortalized Keratinocytes and Glioma Cells in Vitro. 31652556

2019

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression BEFREE A strong negative correlation was observed between the level of miR-26b and COX-2 in 30 glioma tissues. 28800785

2019

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE Therefore, COX-2 and survivin may be sensitive predictors of a negative clinical prognosis for patients with glioma. 28789345

2017

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression BEFREE Paraffin-embedded glioma specimens were detected for the COX-2 expression using immunohistochemistry. 28306608

2017

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE Further, targeting MET and Cox-2 may represent an attractive target therapy for glioma. 26097553

2015

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation BEFREE However, the relationship between the prostaglandin-endoperoxide synthase 2 (PTGS2) genetic polymorphism and glioma remains unclear in the Chinese population. 25966079

2015

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression BEFREE Increased COX-2 expression directly correlates with glioma grade and is associated with shorter survival in glioblastoma (GBM) patients. 24659686

2014

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE Expression analysis further revealed that Cox-2 was elevated in glioma and associated with survival of patients. 22406049

2012

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE This led to our interest in assessing the response of glioma cell lines to treatment with celecoxib, a selective COX-2 inhibitor. 21220497

2011

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE COX-2 regulates the proliferation of glioma stem like cells. 21763744

2011

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 GeneticVariation BEFREE In the single-locus analysis of the 23 examined SNPs, 1 pro-inflammatory and 2 anti-inflammatory gene SNPs were significantly associated with glioma risk (COX2/PTGS2, rs20417 [OR = 1.41]; IL10, rs1800896 [OR = 1.57]; and IL13, rs20541 [OR = 0.39], respectively). 20406895

2010

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression BEFREE A CD133(+)-enriched U87 glioma cell population, isolated from parental U87 cells with magnetic cell sorting technology, also grew as neurospheres and showed enhanced COX-2 expression. 19272160

2009

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE Epidermal growth factor-dependent cyclooxygenase-2 induction in gliomas requires protein kinase C-delta. 19169273

2009

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression BEFREE Expression of p-Akt and COX-2 in gastric adenocarcinomas and adenovirus mediated Akt1 and COX-2 ShRNA suppresses SGC-7901 gastric adenocarcinoma and U251 glioma cell growth in vitro and in vivo. 19925030

2009

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE The U87MG glioma cell line is a good model for COX-2 induction in glioma cell lines. 19029777

2008

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression LHGDN The U87MG glioma cell line is a good model for COX-2 induction in glioma cell lines. 19029777

2008

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE All COX-2 inhibitors reduced proliferation of the glioma cell lines irrespective of their COX-2 expression level. 17729162

2007

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression BEFREE Finally, treatment of glioma cell lines with prostaglandin E2, the predominant product of COX-2 activity, results in increased vascular endothelial growth factor expression, thus potentially linking elevations in COX-2 expression with tumor angiogenesis in malignant gliomas. 17616668

2007

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 AlteredExpression LHGDN We found that EGF-mediated stimulation of EGFR tyrosine kinase in human glioma cell lines induces expression of both COX-2 mRNA and protein. 17616668

2007

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker CTD_human The induction of cyclooxygenase-2 (COX-2) expression is associated with more aggressive gliomas and poor survival. 15561105

2005

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker LHGDN Furthermore, our data show that pharmacological concentrations of celecoxib may interfere with the proapoptotic action of R(+)-MA and anandamide, suggesting that cotreatment with COX-2 inhibitors could diminish glioma regression induced by these compounds. 15361550

2004

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0017638
Disease: Glioma
Glioma
0.400 Biomarker BEFREE Furthermore, our data show that pharmacological concentrations of celecoxib may interfere with the proapoptotic action of R(+)-MA and anandamide, suggesting that cotreatment with COX-2 inhibitors could diminish glioma regression induced by these compounds. 15361550

2004