Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0018801
Disease: Heart failure
Heart failure
0.350 Biomarker BEFREE We identified several proteins (including serpinA3 and A1, fibronectin, ceruloplasmin, and paraoxonase 1) that were elevated in human patients with chronic HF (n=101) compared with healthy subjects (n=180; P<0.001). 29459363

2018

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0018801
Disease: Heart failure
Heart failure
0.350 AlteredExpression BEFREE Decreased arylesterase (ArylE) activity of paraoxonase-1, a HDL-associated protein with anti-inflammatory and antioxidant properties, has been associated with increased risk of cardiac events in patients with ischaemic heart failure (HF). 28176482

2017

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0018801
Disease: Heart failure
Heart failure
0.350 GeneticVariation BEFREE The interaction between HDLC<1mmol/L and the PON1 575GG genotype was found to influence the risk of iHF (OR=7.2, P=0.009). 27863359

2017

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0018801
Disease: Heart failure
Heart failure
0.350 Biomarker BEFREE The aim of this study was to determine the phenotype distribution of PON1 in patients with cardiac disease who were classified in coronary artery bypass grafting (CABG), heart valve disease (HVD), heart failure (HF) and ST elevation myocardial infarction (STEMI) groups and healthy subjects as a control group. 28721150

2017

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0018801
Disease: Heart failure
Heart failure
0.350 AlteredExpression BEFREE Males, smoking, diabetes, and heart failure were identified as factors that influenced PON1 activity. 28038449

2017

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0018801
Disease: Heart failure
Heart failure
0.350 Biomarker CTD_human Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice. 26670611

2016