Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 282617
Gene Symbol: IFNL3
IFNL3
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 Biomarker BEFREE Changes in LDL among CHC patients who achieved SVR differed by IFNL4 genotype, which implicates the interferon-λ4 protein in metabolic changes observed in HCV-infected patients. 31504644

2020

Entrez Id: 282617
Gene Symbol: IFNL3
IFNL3
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 Biomarker BEFREE Interferon lambda 4 (IFNλ4) has been recently known and studied for its role in hepatitis C virus (HCV) infection, but its clinical potential is significantly hampered due to its poor expression in vitro. 31479875

2020

Entrez Id: 282617
Gene Symbol: IFNL3
IFNL3
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 GeneticVariation BEFREE Single-nucleotide polymorphisms (SNPs) near interferon lambda 3/4 (IFNL3/4) gene are associated with spontaneous clearance and treatment response in patients with hepatitis C virus (HCV) infection. 31838260

2020

Entrez Id: 3077
Gene Symbol: HFE
HFE
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 GeneticVariation BEFREE We determined prevalence of chronic HCV infection in consecutive Alabama and Ontario referred adults with HFE p.C282Y homozygosity. 31056361

2020

Entrez Id: 975
Gene Symbol: CD81
CD81
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 AlteredExpression BEFREE Human thyrocytes express major HCV entry factors including CD81, occludin, claudin-1, and scavenger receptor class B1. 31784757

2020

Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 Biomarker BEFREE In the 1990s, interferons alpha-2 were used in the treatment of HCV and in the next decade HCV therapy was based on pegylated interferon alpha-2 in combination with ribavirin. 30685524

2019

Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 Biomarker BEFREE Thus, the use of latent IFNα2b can be considered again as an option for treatment of HCV infection in combination with direct acting antivirals rather than alone with improved safety profile. 31350425

2019

Entrez Id: 282617
Gene Symbol: IFNL3
IFNL3
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 GeneticVariation BEFREE We show that genetic variants within the IFN lambda 4 (<i>IFNL4</i>) locus are the major factors associated with the studied traits, accordingly with observations in other HCV genotypes and with comparable effect sizes. 31260374

2019

Entrez Id: 282617
Gene Symbol: IFNL3
IFNL3
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 GeneticVariation BEFREE IL28B - CC is the predominant variant among the HCV-infected individuals in Singapore. 29926111

2019

Entrez Id: 282617
Gene Symbol: IFNL3
IFNL3
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 GeneticVariation BEFREE The combination of circulating CXCL10 and single nucleotide polymorphisms (SNPs) in IL-28B can identify patients with acute HCV infection most likely to undergo spontaneous HCV clearance and those in need of early antiviral therapy. 31485460

2019

Entrez Id: 282617
Gene Symbol: IFNL3
IFNL3
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 GeneticVariation BEFREE The most significant positive factors affecting the SC HCV included IL-28B single nucleotide polymorphism (SNP) rs12979860 (CC) and SNP rs8099917 (TT) (OR 4.03, p<0.001) and (OR 3.14, p<0.002), female gender (OR 2.72, p<0.001), young age (OR 2.30, p<0.008), and past history of jaundice (OR 5.12, p<0.001). 31060998

2019

Entrez Id: 282617
Gene Symbol: IFNL3
IFNL3
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 GeneticVariation BEFREE Multivariate logistic regression analysis indicated that cholesterol, triglyceride, low-density lipoprotein, 25-hydroxyvitamin D, platelets, duration of hemodialysis, HCV subtypes, IFNL3 rs12979860 TT, IFNL3 rs8099917 GG, IFNL3 rs12980275 GG, and IFNL4 ss469415590 ΔG/ΔG genotypes were associated with OCI. 30821879

2019

Entrez Id: 3440
Gene Symbol: IFNA2
IFNA2
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 Biomarker BEFREE Sustained virological response (SVR) in hepatitis C virus (HCV) patients treated with pegylated interferon α-2a and ribavirin is associated with reduced insulin resistance (IR), measured as a reduction of homeostasis model assessment (HOMA) scores after 24 weeks of therapy, and reduced fasting serum insulin and serum glucose levels. 31602234

2019

Entrez Id: 282617
Gene Symbol: IFNL3
IFNL3
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 Biomarker BEFREE Polymorphisms near the interferon lambda 3 (IFNL3, also known as IL28B) have been proposed to be associated with interferon (IFN)-induced hepatitis C virus (HCV) clearance, but the impact of IFNL3 variations on the result of IFN-based therapy in chronic hepatitis B (CHB) infection is still poor understood. 31201901

2019

Entrez Id: 1234
Gene Symbol: CCR5
CCR5
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 Biomarker BEFREE We evaluated the effect of CCR5 blockade or knockdown on HCV replication in Huh7.5JFH1 cells. 31661521

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 Biomarker BEFREE The cytolysis of HCV-infected hepatocytes is mediated by perforin and granzyme B secreted by cytotoxic T lymphocyte (CTL) and natural killer (NK) cells, whereas noncytolytic HCV clearance is mediated by interferon gamma (IFN-γ) secreted by CTL and NK cells. 31027278

2019

Entrez Id: 282617
Gene Symbol: IFNL3
IFNL3
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 GeneticVariation BEFREE Sensitivity analyses suggested the robustness of the results in this meta-analysis.Both IL28B rs12979860 CC and rs8099917 TT genotypes are protective factors for the development of HCC among patients with HBV or HCV infection. 31568008

2019

Entrez Id: 282617
Gene Symbol: IFNL3
IFNL3
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 Biomarker BEFREE Both the subtypes were similar in age, sex, body mass index, IL28B, and baseline HCV RNA. 30861150

2019

Entrez Id: 23586
Gene Symbol: DDX58
DDX58
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 Biomarker BEFREE Taken together, these data reveal that the NS4A Y16 residue regulates a noncanonical Riplet-TBK1-IRF3-dependent, but RIG-I-MAVS-independent, signaling pathway that limits HCV infection.<b>IMPORTANCE</b> The HCV NS3-NS4A protease complex facilitates viral replication by cleaving and inactivating the antiviral innate immune signaling proteins MAVS and Riplet, which are essential for RIG-I activation. 31534039

2019

Entrez Id: 3458
Gene Symbol: IFNG
IFNG
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 Biomarker BEFREE Our data show that NK cells from HCV+ patients have an unbalanced ability to produce IFNγ and to kill target cells in haplotype A and B carriers, suggesting the existence of complex functional differences governed by KIR-HLA interaction, particularly on KIR3DL1 expressing NK cells. 31177636

2019

Entrez Id: 975
Gene Symbol: CD81
CD81
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 Biomarker BEFREE HCV E2 protein when associated with CD81 may be responsible for B cell lymphoproliferative disorders, as extrahepatic manifestation. 31755827

2019

Entrez Id: 282617
Gene Symbol: IFNL3
IFNL3
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 GeneticVariation BEFREE This commentary highlights two such host factors that were initially judged to be important but over time have moved in opposite directions: hepatitis C virus and the IL28B locus as well as HIV and the Δ32-CCR5 mutation. 31447128

2019

Entrez Id: 282617
Gene Symbol: IFNL3
IFNL3
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 GeneticVariation BEFREE Host DNA from all HCV positive patients and age- and sex-matched non-HCV-infected control individuals were analysed for IL28B single nucleotide polymorphism (SNP) (rs12979860 and rs8099917). 30865664

2019

Entrez Id: 282617
Gene Symbol: IFNL3
IFNL3
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 GeneticVariation BEFREE On the other hand, we confirmed in this study that the polymorphic variants within IFNL3 and TLR2 immune response genes are significantly associated with HCV-related disease progression in our cohort of Italian patients. 30930876

2019

Entrez Id: 975
Gene Symbol: CD81
CD81
CUI: C0019196
Disease: Hepatitis C
Hepatitis C
0.400 Biomarker BEFREE Our results are consistent with sequential HCV-receptor interactions, whereby initial interaction between the HCV E2 glycoprotein and SR-B1 facilitates the accumulation CD81 receptors, leading to viral entry. 30883541

2019