Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0020445
Disease: Hypercholesterolemia, Familial
Hypercholesterolemia, Familial
0.370 GeneticVariation BEFREE PON1 QQ192 genotype showed a significantly higher association with FH (p=0.0002). 30044465

2019

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0020445
Disease: Hypercholesterolemia, Familial
Hypercholesterolemia, Familial
0.370 AlteredExpression BEFREE Erratum: Decreased serum PON1 arylesterase activity in familial hypercholesterolemia patients with a mutated LDLR gene. 31323079

2019

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0020445
Disease: Hypercholesterolemia, Familial
Hypercholesterolemia, Familial
0.370 Biomarker CTD_human The effect of statin therapy on plasma high-density lipoprotein cholesterol levels is modified by paraoxonase-1 in patients with familial hypercholesterolaemia. 16238680

2005

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0020445
Disease: Hypercholesterolemia, Familial
Hypercholesterolemia, Familial
0.370 AlteredExpression LHGDN Variation at the paraoxonase gene locus contributes to carotid arterial wall thickness in subjects with familial hypercholesterolemia. 15642273

2005

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0020445
Disease: Hypercholesterolemia, Familial
Hypercholesterolemia, Familial
0.370 GeneticVariation BEFREE PON1 genotypes (L55M, Q192R, -107C/T, -162A/G, -824G/A, and -907G/C) were determined in 302 patients with familial hypercholesterolemia. 15576850

2005

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0020445
Disease: Hypercholesterolemia, Familial
Hypercholesterolemia, Familial
0.370 Biomarker BEFREE The effect of statin therapy on plasma high-density lipoprotein cholesterol levels is modified by paraoxonase-1 in patients with familial hypercholesterolaemia. 16238680

2005

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0020445
Disease: Hypercholesterolemia, Familial
Hypercholesterolemia, Familial
0.370 Biomarker CTD_human Genetic determinants of plasma HDL-cholesterol levels in familial hypercholesterolemia. 16030523

2005

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0020445
Disease: Hypercholesterolemia, Familial
Hypercholesterolemia, Familial
0.370 GeneticVariation BEFREE In 187 patients with familial hypercholesterolemia, we studied the seven most common single nucleotide polymorphisms (SNPs) in both the coding and promoter sequences of PON1 (L55M, Q192R, T-107C, C-126G, G-162A, G-824A, and C-907G) in terms of PON1 activity and intima media thickness (IMT) of the carotid arterial wall, a validated surrogate marker for CVD. 15642273

2005

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0020445
Disease: Hypercholesterolemia, Familial
Hypercholesterolemia, Familial
0.370 GeneticVariation BEFREE In our study we assessed the frequency and genotype distribution of the PON1 and PON2 polymorphisms in 197 patients with familial hypercholesterolemia (FH), to determine the possible association between these mutations and susceptibility for CVD. 11257265

2001

Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0020445
Disease: Hypercholesterolemia, Familial
Hypercholesterolemia, Familial
0.370 Biomarker BEFREE Low PON1 activities have been found in familial hypercholesterolemia (FH) and diabetes mellitus. 10978257

2000