Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5579
Gene Symbol: PRKCB
PRKCB
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.540 AlteredExpression BEFREE AR, PKC protein levels and related signalling molecules were increased with hyperglycemia and oxidative stress. 31743046

2019

Entrez Id: 5579
Gene Symbol: PRKCB
PRKCB
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.540 Biomarker BEFREE Apn has protective effects against hyperglycemia and can effectively enhance antioxidation, promote the secretion of insulin and reduce the accumulation of glycosylated products in T2DM mice; these effects were associated with inhibition of PKC and promotion of PKA signaling. 28954262

2017

Entrez Id: 5579
Gene Symbol: PRKCB
PRKCB
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.540 AlteredExpression BEFREE Hyperglycemia induced the expression of PKC-beta1 and PKC-beta2; however, only inhibition of PKC-beta1 but not PKC-beta2 led to a significant decrease of FGF-2 levels. 19279131

2009

Entrez Id: 5579
Gene Symbol: PRKCB
PRKCB
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.540 Biomarker CTD_human Inhibition of PKC beta by ruboxistaurin does not enhance the acute blood pressure response to nitroglycerin. 17443133

2007

Entrez Id: 5579
Gene Symbol: PRKCB
PRKCB
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.540 Biomarker RGD Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase c-{alpha} and -{beta}. 15616014

2005

Entrez Id: 5579
Gene Symbol: PRKCB
PRKCB
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia
0.540 Biomarker BEFREE Taken together, our data suggest that hmunc13 serves as a diacylglycerol-activated, PKC-independent signaling pathway capable of inducing apoptosis and that this pathway may contribute to the renal cell complications of hyperglycemia. 10233166

1999