Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0023343
Disease: Leprosy
Leprosy
0.190 GeneticVariation GWASCAT Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy. 25642632

2015

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0023343
Disease: Leprosy
Leprosy
0.190 Biomarker BEFREE The frequency of HLA-DRB1* alleles between the control group and leprosy patient subgroups presenting different forms of the disease showed that the HLA-DRB1*16 (16.13% vs. 8.24%, OR = 4.10, CI = 1.27-13.27, p = 0.010) and HLA-DRB1*14 (5% vs. 3.53%, OR = 4.63, CI = 1.00-21.08, p = 0.032) alleles were significantly more frequent in patients with different clinical subtypes of leprosy. 23283466

2012

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0023343
Disease: Leprosy
Leprosy
0.190 GeneticVariation BEFREE We have conducted an association analysis of more than 1,500 individuals from different case-control and family studies, and observed consistent associations between genetic variants in both TLR1 and the HLA-DRB1/DQA1 regions with susceptibility to leprosy (TLR1 I602S, case-control P = 5.7 x 10(-8), OR = 0.31, 95% CI = 0.20-0.48, and HLA-DQA1 rs1071630, case-control P = 4.9 x 10(-14), OR = 0.43, 95% CI = 0.35-0.54). 20617178

2010

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0023343
Disease: Leprosy
Leprosy
0.190 Biomarker BEFREE These data confirm the positive association of HLA-DR2 (DRB1*16) with leprosy per se, and the protector effect of DRB1*04 against lepromatous leprosy in Brazilian patients. 19698125

2009

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0023343
Disease: Leprosy
Leprosy
0.190 GeneticVariation GWASCAT Genomewide association study of leprosy. 20018961

2009

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0023343
Disease: Leprosy
Leprosy
0.190 GeneticVariation BEFREE HLA-DRB1 alleles are associated with leprosy susceptibility in a Chinese population. 20003324

2009

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0023343
Disease: Leprosy
Leprosy
0.190 GeneticVariation GWASDB Genomewide association study of leprosy. 20018961

2009

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0023343
Disease: Leprosy
Leprosy
0.190 GeneticVariation BEFREE The HLA-DRB1 alleles could act alone or in combination with other genes to confer differential susceptibility and also protection to leprosy disease in endemic areas of the American continent. 18275683

2008

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0023343
Disease: Leprosy
Leprosy
0.190 GeneticVariation BEFREE In this work, we analyzed the influence of the HLA-DRB1 locus on leprosy susceptibility per se and disease type using a case-control design carried out in Brazilians (578 cases and 691 controls) and a replication study based on a family design in a Vietnamese population (n=194 families). 17396103

2007

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0023343
Disease: Leprosy
Leprosy
0.190 Biomarker BEFREE The associations with MICA and MICB cannot be accounted for by linkage disequilibrium with the HLA class II locus indicating a role in genetic susceptibility to leprosy that is independent of HLA-DRB1. 16923796

2006

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0023343
Disease: Leprosy
Leprosy
0.190 GeneticVariation BEFREE The resulting response translates to various forms of leprosy depending on degree of charge consonance between M. leprae and host DRB1 allele. 10540160

1999

Entrez Id: 3123
Gene Symbol: HLA-DRB1
HLA-DRB1
CUI: C0023343
Disease: Leprosy
Leprosy
0.190 Biomarker BEFREE The much stronger association of DRB1*1501 with the multibacillary form than with the TT type of leprosy suggests a possible role in the differential immune response to M. leprae antigens. 8284786

1993