Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker BEFREE IL-1RA has the potential to play a role in the treatment of gastric cancer. 29344744

2018

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Synergistic effect of H. pylori infection and IL-1B-511*T/IL-1RN*2 genotypes was also observed in association with significantly higher risk of developing GC. 28110439

2017

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE The variant homozygote and heterozygote genotype of rs9005 in IL-1RN were significantly associated with increased risks of GC (ORadjusted [95%CI]: 1.71[1.04-2.81] and ORadjusted[95%CI]: 1.36 [1.04-1.78]). 26632693

2015

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE In this retrospective cohort study we genotyped 154 patients with gastric cancer for IL-1β and IL-1RN variations. 24557417

2015

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Haplotypes established from the three polymorphisms of IL-1RN were not associated with a risk of GC. 24080970

2014

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE The frequency of IL-1RN alleles from patients with chronic gastritis and GC indicated that there was no difference between the genotypes of the groups studied. 22714811

2012

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE So, our results indicated that the IL-1RN*2 allele may increase the risk of gastric cancer and precancerous lesions in the Southeast Brazilian population, reinforcing the importance of host genetic factors in the susceptibility to gastric cancer and the participation of cytokines in both the inflammation and the carcinogenic process. 22327782

2012

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE To investigate the associations between interleukin (IL)-1B and IL-1RN polymorphisms and gastric cancers among the Tibet, Hui and Han ethnicities. 23323013

2012

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE The data from the current study demonstrated that the genotype CC or CT of IL-1B-31, TT or CT of IL-1B-511, and 2L of IL-1RN increased risk of gastric cancer in this Chinese population and the risk was further enhanced by H. pylori. 21243433

2011

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker BEFREE These cytokine gene polymorphisms, as well as those of IL-1B, IL-1RN and TNF-A, may be used to identify groups at higher risk of gastric cancer and peptic ulcer, and those suitable for their prevention by H. pylori eradication therapy in Western populations. 20222161

2010

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE There was a statistical association between the presence of the IL-1RN*2 allele and gastric cancer (odds ratio 2.2, 95% confidence interval=1.2-3.7, P=0.01). 18779738

2009

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Our findings indicate that the IL-1B and IL-1RN polymorphisms are associated with the development of GC and H. pylori infection markedly increases the risk of GC in North Indian population. 19607807

2009

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Atrophic body gastritis patients harbouring the wild type of IL-1B-511/IL-1RN polymorphisms were not different from those harbouring the proinflammatory pattern as far as regards gender, age, gastric cancer family history and metaplastic atrophy. 18047563

2008

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE The age-sex-adjusted odds ratios (OR) for the IL-1B-511 T genotype relative to the C/C genotype (OR = 0.82, 95% confidence interval [CI] 0.41-1.65), IL-1RN*2 genotype relative to the L/L genotype (OR = 0.85, 95% CI 0.41-1.78), and IL-2-330 T genotype relative to the G/G genotype (OR = 1.94, 95% CI 0.76-4.96) were not increased in GC. 18761558

2008

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Multivariate regression analysis showed that cagE, babA2, and IL-1RN-1/2 genotypes were independent predictors of GC, but when patients with benign disorders were grouped together (NUD + DU) and compared with patients with GC, regression analysis disclosed that babA2 (P = 0.000) and IL-1B-31 gene polymorphisms (CC or CT) (P = 0.01) were the only independent markers of GC. 18807132

2008

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE IL1RN 2R/2R genotype [odds ratio (OR) 2.43; 95% confidence interval (CI) 1.19-4.96] and allele IL1RN Ex5-35C were associated with an increased risk of Hp(+) non-cardia GC. 18628242

2008

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE IL-1B-511T and IL-1RN *2 were associated with risks of gastric cancer. 18565646

2008

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE In conclusion, IL-1B-511 and IL-1RN genetic polymorphisms are associated with an increased risk of developing gastric cancer. 17096351

2007

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE A comprehensive analysis of 207 SNP of 11 cytokine genes revealed that variations in IL-4 and IL-1RN genes are negatively associated with the risk of developing gastric cancer following H. pylori infection. 17444864

2007

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Three hundred and ninety-nine patients with gastroduodenal diseases (129 chronic gastritis, 127 duodenal ulcer and 143 non-cardiac gastric cancer) and 264 healthy controls were genotyped for IL-1B-511 and IL-1RN gene polymorphisms by the PCR-RFLP method. 17295877

2007

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE We aimed to test for associations between polymorphisms in IL1B (-31 and +3954), IL10-592 and IL1RN variable number of tandem repeats (VNTR) and risk of gastric cancer in a Mexican population. 16114018

2006

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE There was an association between the presence of IL-1RN*2 allele and gastric cancer [odds ratio (OR) = 2.2, 95% confidence interval (CI) = 1.0-3.3, P = 0.04). 17235630

2006

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker BEFREE For the associations between IL-1RN and gastric cancer, ORs (95% CIs) for *2/L versus LL and *2/*2 versus L/L were 1.15 (0.96-1.38) and 1.23 (0.79-1.92). 17035400

2006

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms and gastric cancer: a meta-analysis. 16985030

2006

Entrez Id: 3557
Gene Symbol: IL1RN
IL1RN
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Our study investigates the role of the IL-1B-31, IL-1RN and TNF-A-308 gene polymorphisms as risk factors for the development of GC in a Mexican population. 15540224

2005