Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker BEFREE Bioinformatics analysis predicted that there is a SPRY4-IT1/miR-101-3p/AMPK axis in GC progression. 31330497

2019

Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker BEFREE PRKAA1 knockdown in GC cells showed significant decreases in the cell invasion and migration and inhibited MMP-2 expression and NF-κB activation, whereas PRKAA1 involved in NF-κBp50 mediated GC cell invasion and migration. 31841039

2019

Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker BEFREE Adrenergic modulation of AMPK‑dependent autophagy by chronic stress enhances cell proliferation and survival in gastric cancer. 30896863

2019

Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker BEFREE LKB1-AMPK activation in GC cell lines was tumor suppressive, as metformin (an AMPK activator) inhibited GC cell growth in the CAB39L-silenced cells. 30054562

2018

Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE The aim of this study was to evaluate the association between TLR1 and PRKAA1 genes polymorphisms and H. pylori infection, atrophic gastritis (AG) or GC in the European population. 30574617

2018

Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker BEFREE However, the Kaplan-Meier estimate showed that there is no significant difference of OS and RFS between the low and high PRKAA1 TPM groups in gastric cancer, breast cancer, and esophageal carcinoma. 30340465

2018

Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker BEFREE MTDH-stimulated cancer resistance to 5-FU may be mediated through autophagy activated by the AMPK/ATG5 pathway in GC. 29635244

2018

Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Genetic variations in PRKAA1 predict the risk and progression of gastric Cancer. 30253744

2018

Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker BEFREE The anti-gastric cancer mechanism of BBR might be involved in AMPK-HNF4α-WNT5A signaling pathway. 30405404

2018

Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Furthermore, in analyses stratified by either source of control or geographical origin of subjects, a statistically significant inverse relationship was detected between <i>PRKAA1 rs13361707</i> C/T polymorphism and GC risk. 28978122

2017

Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Our results indicated that H. pylori infection, CagA status, and PRKAA1 polymorphisms were risk factors for gastric cancer in Koreans, and that the combination of two of these factors rather than their independent effects synergistically increased the risk. 27726301

2016

Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Our results confirm an association between gastric cancer in Europeans and three loci previously reported in Asians, MUC1, PRKAA1 and PSCA, refine the association signal at PRKAA1 and support a pathogenic role for the tandem repeat identified in MUC1. 26098866

2015

Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker BEFREE Our results demonstrate that CAMKK2 signals in gastric cancer through AMPK activation and suggest that CAMKK2 could be a novel therapeutic target in gastric cancer. 25756516

2015

Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker CTD_human Our results confirm an association between gastric cancer in Europeans and three loci previously reported in Asians, MUC1, PRKAA1 and PSCA, refine the association signal at PRKAA1 and support a pathogenic role for the tandem repeat identified in MUC1. 26098866

2015

Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE In summary, these results indicated that the C allele of PRKAA1 rs13361707 was a low-penetrate risk factor for GCa. 26485766

2015

Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker BEFREE The PRKAA1 gene showed a significant gene-based association with gastric cancer in the VEGAS test. 25024613

2014

Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 Biomarker BEFREE We identified HNF4α-WNT5A regulation in the cross-talk between the AMPK metabolic pathway and the WNT signaling pathway, and further identified WNT5A as a potential therapeutic target for GC. 24681952

2014

Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation BEFREE Genetic variations in the PRKAA1 and ZBTB20 genes and gastric cancer susceptibility in a Korean population. 23861218

2013

Entrez Id: 5562
Gene Symbol: PRKAA1
PRKAA1
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach
0.500 GeneticVariation GWASDB A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1. 22037551

2011