Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Combined therapeutic targeted strategies are awaited in NRAS-mutated and KIT-altered melanoma and could provide additional benefit. 31833955

2020

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Similar results were obtained for TRB CDR3s and NRAS mutants in melanoma. 31740784

2020

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE Intra-patient heterogeneity was detected in 13.3% of patients for both BRAF and NRAS genes and was not associated with clinico-pathological characteristics of melanomas or metastases. 31774543

2020

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Accordingly, in a cohort of 79 BRAF/NRAS double wild type cutaneous melanoma and 17 mucosal melanoma KIT mutation was assessed by Sanger sequencing of exons 9,11,13,17 and 18. 31848942

2020

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Our findings thus show a new pathway involved in NRAS-mutant melanoma resistance and provide new opportunities for novel therapeutic options. 31549767

2020

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Our study aims to evaluate and review other studies that present the frequency of mutations of BRAF, NRAS, and KIT genes for different populations, and analyse correlation to their clinical-pathological characteristics and to the demographics of melanoma. 31274706

2020

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Melanoma onset and progression are associated with a high variety of activating mutations in the MAPK-pathway, most frequently involving BRAF (35-45%) and NRAS (15-25%) genes, but also c-KIT and PTEN. 31446019

2019

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Both the melanomas harbor KIT mutation in approximately 15% of the cases; BRAF or NRAS mutation is found in approximately 10-15% of acral melanoma, but these mutations are less frequent in mucosal melanoma. 30675668

2019

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Remarkably two-thirds of BRAF/NRAS wild-type melanomas harbor activating mutations or CNVs in receptor tyrosine kinases. 30561760

2019

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE Further leverage of the SPRY4 pathway may also hold therapeutic promise for NRAS(Q61) melanomas. 30651601

2019

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 AlteredExpression BEFREE Neural crest state activation in NRAS driven melanoma, but not in NRAS-driven melanocyte expansion. 29883661

2019

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE Because the Mitogen-Activated Protein Kinase (MAPK) pathway plays such a significant role in melanoma development, we explore v-raf murine sarcoma viral oncogene homolog B (<i>BRAF)</i> and neuroblastoma RAS viral oncogene homolog (<i>NRAS)</i> mutations in mucosal melanoma and compare them to the mutation profiles in cutaneous melanoma and other tumors with <i>BRAF</i> and <i>NRAS</i> mutations. 31398831

2019

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE A MEK1/2 inhibitor, binimetinib is promising as a therapeutic agent for malignant melanoma with N-RAS mutation. 31129802

2019

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE Mutational status of NRAS is required in several types of cancer like colorectal or cutaneous melanoma. 29101736

2019

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Disseminated intravascular coagulation and melanoma: a novel case occurring in metastatic melanoma with BRAF and NRAS mutations and systematic review. 31095038

2019

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE The neuroblastoma RAS viral oncogene homolog isoforms appear to play varying roles in melanoma phenotype and could potentially serve as biomarkers for therapeutic response and disease prognosis. 31116161

2019

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 Biomarker BEFREE Finally, we developed ZT-12-037-01 (1a) as a specific STK19-targeted inhibitor and showed that it effectively blocks oncogenic NRAS-driven melanocyte malignant transformation and melanoma growth in vitro and in vivo. 30712867

2019

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE The activating NRAS p.Q61R variant is a known "hotspot" variant, frequently identified in several types of human cancer, especially melanoma. 30542204

2019

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE BRAF and NRAS mutations and antitumor immunity in Korean malignant melanomas and their prognostic relevance: Gene set enrichment analysis and CIBERSORT analysis. 31630873

2019

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Targeted therapy may be useful for patients with CJM, especially those with activating BRAF mutations, whereas NRAS-mutated melanomas are relatively resistant. 31247083

2019

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Magnolol induces cell death through PI3K/Akt-mediated epigenetic modifications boosting treatment of BRAF- and NRAS-mutant melanoma. 30793515

2019

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE In LNs of melanoma patients, we detected the expression of melanoma-associated transcripts including MLANA (encoding for MelanA protein), analyzed the BRAF and NRAS mutational status and confirmed the malignant origin of isolated melanoma DCCs by comparative genomic hybridization. 30586191

2019

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Combinatorial inhibition of MEK1/2 and CDK4/6 is currently undergoing clinical investigation in NRAS-mutant melanoma. 30819666

2019

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Sixty five consecutive formalin-fixed paraffin-embedded (FFPE) melanoma samples were prospectively tested for BRAF mutations with the VE1 (anti-BRAF V600E) antibody and for both BRAF and NRAS mutations with the Idylla NRAS-BRAF-EGFR S492R Mutation Assay cartridges. 31415669

2019

Entrez Id: 4893
Gene Symbol: NRAS
NRAS
CUI: C0025202
Disease: melanoma
melanoma
0.700 GeneticVariation BEFREE Isocitrate dehydrogenase 1 mutations in melanoma frequently co-occur with NRAS mutations. 30003571

2018