|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
GeneticVariation |
BEFREE |
To elucidate the frequency of CLs and their association with HLA-DRB1 and DPB1 alleles in Japanese MS patients.
|
28474969 |
2018 |
|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
GeneticVariation |
BEFREE |
We aimed to clarify the effects of latitude and the HLA-DRB1 and HLA-DPB1 genes on disease severity in Japanese patients with MS.
|
27599848 |
2016 |
|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
GeneticVariation |
BEFREE |
We analysed human leucocyte antigen (HLA)-DRB1 and HLA-DPB1 alleles, and IgG antibodies against Helicobacter pylori, Chlamydia pneumoniae, varicella zoster virus and Epstein-Barr virus nuclear antigen (EBNA) in 116 patients with NMO, including 39 patients with neuromyelitis optica spectrum disorder (NMOSD), 145 multiple sclerosis (MS) patients and 367 unrelated healthy controls.
|
23038741 |
2013 |
|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
GeneticVariation |
BEFREE |
To analyze the role of HLA-DRB1 and -DPB1 alleles in the pathogenesis of neuromyelitis optica (NMO) and multiple sclerosis in Southern Han Chinese.
|
21130504 |
2011 |
|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
GeneticVariation |
BEFREE |
Genotyping of HLA-DRB1 and -DPB1 alleles was performed in 60 patients with conventional MS and 95 controls.
|
19965521 |
2009 |
|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
Biomarker |
CTD_human |
Impact of negatively charged patches on the surface of MHC class II antigen-presenting proteins on risk of chronic beryllium disease.
|
17956852 |
2008 |
|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
GeneticVariation |
BEFREE |
Genotyping of HLA-DRB1 and -DPB1 alleles was performed in 121 consecutive Japanese patients with clinically definite MS based on the Poser criteria and 125 healthy controls.
|
18952831 |
2008 |
|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
GeneticVariation |
BEFREE |
IFNB-1b should not be administered to demyelinating patients with genetic and clinical characteristics mimicking NMO such as HLA DPB1*0501 allele, longitudinally extensive spinal cord lesion, blindness and CSF pleocytosis even if they have symptomatic cerebral lesions as typically seen in MS.
|
17125797 |
2007 |
|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
Biomarker |
BEFREE |
Periventricular white matter lesions (PVL) were noted in 31 of 32 (97%) DPB1*0301-positive non-OSMS patients but in only 22 out of 135 (16%) DPB1*0301-negative non-OSMS patients and two out of 26 (8%) OSMS patients.
|
16459716 |
2006 |
|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
GeneticVariation |
BEFREE |
Conventional MS in Japanese people is, like MS in white people, associated with HLA-DRB1*1501, whereas opticospinal MS is associated with HLA-DPB1*0501.
|
12849268 |
2003 |
|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
GeneticVariation |
BEFREE |
Moreover, we discovered no epistatic effect of the MBP gene on the HLA/MHC DRB1,DQB1, DPB1 loci or on alleles defined by D6S1683 marker found to be associated with MS in Sardinians.
|
12420096 |
2002 |
|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
AlteredExpression |
BEFREE |
We show that phagocytic macrophages in active demyelinating MS lesions displayed a moderate to strong immunostaining of the MHC-specific transcription factors RFX and CIITA, as well as the general transcription factors NF-kappaB, IRF1, STAT1, USF, and CREB, which was congruent with a strongly enhanced expression of HLA-DR, HLA-DQ, HLA-DP, and HLA class I.
|
11571785 |
2001 |
|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
Biomarker |
BEFREE |
The rate of Bsm I and Apa I haplotypes was much higher in bA/bA-positive MS patients than in the controls (P=0.0003), and in the bA positive MS patients, the positive rate of DPB1*0501 was higher than that of the bA-positive controls and that of the bA-negative MS patients (P(corr)=0.0308 and P(corr)=0.0033, respectively).
|
10967184 |
2000 |
|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
Biomarker |
BEFREE |
Our results indicate that OS-MS is a DPB 1*0501-associated subgroup of MS, and that DPB1*0501 is also correlated with risk of conventional MS in Japanese.
|
10787110 |
2000 |
|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
Biomarker |
BEFREE |
In conclusion, OS-MS is a DPB1*0501-associated distinct subtype of MS, and DPB1*0301 is the most strongly associated allele with conventional MS in Japanese.
|
10777094 |
2000 |
|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
Biomarker |
BEFREE |
The marked differences in the clinical and MRI findings as well as in the immunogenetic backgrounds between the opticospinal multiple sclerosis and Western-type multiple sclerosis together suggest that HLA-DPB1*0501-associated opticospinal multiple sclerosis is a distinct subtype of multiple sclerosis.
|
10468508 |
1999 |
|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
Biomarker |
BEFREE |
Our results suggest that self-presentation by HLA-DP may play an important role in epitope spreading and in the propagation of self-recognition during the clinical progression of MS.
|
9544235 |
1998 |
|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
GeneticVariation |
BEFREE |
In the present study, we found that the frequencies of DPA1 *0202 and DPB1 *0501 alleles were significantly increased in patients with Asian type MS, as compared with findings in 92 healthy control subjects (91.3% vs 65.2%, P(corr)<0.05 and 89.1% vs 63.0%, P(corr)<0.05 respectively), but not in Western type MS. Our data provide further evidence that Asian and Western type MS are distinct regarding the immunogenetic background.
|
9756407 |
1998 |
|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
Biomarker |
BEFREE |
We studied the allelic constitution at the HLA class II DQA1, DQB1, DRB1 and DPB1 in 94 Italian multiple sclerosis (MS) patients and 98 controls.
|
7605774 |
1995 |
|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
Biomarker |
BEFREE |
DPB1*0301 was associated (p = 0.003) with DQB1*0402 (DR8) in Caucasoid MS patients.(ABSTRACT TRUNCATED AT 250 WORDS)
|
8456441 |
1993 |
|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
GeneticVariation |
BEFREE |
HLA-DPB1 gene polymorphism and multiple sclerosis: a large case-control study in the southwest of France.
|
1918327 |
1991 |
|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
Biomarker |
BEFREE |
Serologic DR typing and genomic DRB1, DQA1, DQB1, DPA1, and DPB1 typing using sequence-specific oligonucleotides were performed in 69 multiple sclerosis (MS) patients and 181 healthy controls on in vitro amplified DNA.
|
2001977 |
1991 |
|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
GeneticVariation |
BEFREE |
HLA-DPw4 has been reported to be associated with multiple sclerosis (MS) but our PCR-SSOP analysis of 52 French Canadian MS patients showed no association with either the DPB1*0401 or DPB1*0402 splits of DPw4 or with any other DPB1 allele.
|
1926123 |
1991 |
|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
Biomarker |
BEFREE |
HLA-DP beta and susceptibility to multiple sclerosis: an analysis of caucasoid and Japanese patient populations.
|
2391251 |
1990 |
|
HLA-DPB1
|
Multiple Sclerosis
|
0.400 |
Biomarker |
BEFREE |
DNA typing for HLA-DPB1*02 and -DPB1*04 in multiple sclerosis and juvenile rheumatoid arthritis.
|
2228045 |
1990 |