Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3574
Gene Symbol: IL7
IL7
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 AlteredExpression BEFREE In summary, our findings indicate an augmented type-17 differentiation of MAIT cells in MS patients associated with their IL-7 receptor surface expression, implicating a proinflammatory role of these unconventional T cells in MS immunopathology. 29298833

2018

Entrez Id: 3574
Gene Symbol: IL7
IL7
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation BEFREE Combination of IL-7 and CXCL10 indicated risk for a specific MS clinical form, where IL-7<141 and CXCL10<570pg/ml were associated with the highest risk for PP-MS (OR=22, p=0.01). 28578025

2017

Entrez Id: 3574
Gene Symbol: IL7
IL7
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation BEFREE There was a statistically significant difference in the genotypes of IL-7 rs2887502 between MS and NMO patients (P = 0.014). 26608987

2015

Entrez Id: 3574
Gene Symbol: IL7
IL7
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker BEFREE IL7 is fundamental to development of IL17 producing cells and plays a role in maturation of auto-reactive T-cells, it is also associated with autoimmune disorders including multiple sclerosis and type-1 diabetes. 25933188

2015

Entrez Id: 3574
Gene Symbol: IL7
IL7
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation BEFREE The T-allele in the single nucleotide polymorphism rs6897932 in the gene encoding the IL-7 receptor α (IL7RA) is associated with reduced risk of autoimmune diseases including multiple sclerosis and also affects the course of HIV infection. 25421942

2015

Entrez Id: 3574
Gene Symbol: IL7
IL7
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker BEFREE The IL-7/IL-7R signaling axis participates in cell survival, and perturbation of this pathway has been associated with enhanced susceptibility to MS. A link between IL-23-driven pathogenic T cells and IL-7/IL-7R signaling has previously been proposed, but has not been formally addressed. 26223651

2015

Entrez Id: 3574
Gene Symbol: IL7
IL7
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 AlteredExpression BEFREE Increased expression of IL-7 in the central nervous system as well as in peripheral immune cells is associated with multiple sclerosis and experimental allergic encephalomyelitis. 24224652

2014

Entrez Id: 3574
Gene Symbol: IL7
IL7
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation BEFREE Former studies demonstrated the single nucleotide polymorphism (SNP) rs6897932 C/T in the IL-7 receptor (IL-7R) gene was associated with susceptibility to autoimmune diseases, including multiple sclerosis and type I diabetes. 24242875

2014

Entrez Id: 3574
Gene Symbol: IL7
IL7
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 AlteredExpression BEFREE IL-7 stimulation had a differential effect on both mRNA and protein expression of granzyme A and granzyme B between MS and HC. 22262655

2012

Entrez Id: 3574
Gene Symbol: IL7
IL7
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 AlteredExpression BEFREE IL-7 levels were significantly decreased in 40 MS patients compared with 40 HCs. 22914435

2012

Entrez Id: 3574
Gene Symbol: IL7
IL7
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 AlteredExpression BEFREE We found reduced IL-7Rα expression on conventional T cells and upregulated IL-7 plasma levels together with reduction of RTE-Treg frequencies and Treg function in MS, without clear genetic influence. 21287555

2011

Entrez Id: 3574
Gene Symbol: IL7
IL7
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation BEFREE In conclusion, our findings suggest that IL-7Ralpha polymorphisms can influence T cell development and homeostasis, and thereby contribute to the altered immune regulation associated with disease development in patients with MS. 20072142

2010

Entrez Id: 3574
Gene Symbol: IL7
IL7
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker BEFREE We measured the relative distribution of IL-7 and IL-7R spliced mRNA from patients with MS and healthy individuals and observed extensive alternative splicing of both genes with marked differences in proportional transcript expression levels. 20226540

2010

Entrez Id: 3574
Gene Symbol: IL7
IL7
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation BEFREE Genetic variation in the IL7RA/IL7 pathway increases multiple sclerosis susceptibility. 20112030

2010

Entrez Id: 3574
Gene Symbol: IL7
IL7
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation BEFREE Common genetic variants of IL-7 receptor alpha (IL-7Ralpha) have recently been shown to affect susceptibility to multiple sclerosis (MS) and type 1 diabetes, and survival following bone marrow transplantation. 20097866

2010

Entrez Id: 3574
Gene Symbol: IL7
IL7
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 AlteredExpression BEFREE We demonstrated that angiocidin and interleukin-7 (IL-7) are over-expressed in brain lesions of MS patients. 18207252

2008

Entrez Id: 3574
Gene Symbol: IL7
IL7
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation BEFREE Additional alleles of IL7 and IL2 have been identified as risk factors for MS with small effect. 18612409

2008

Entrez Id: 3574
Gene Symbol: IL7
IL7
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation BEFREE We conclude that the IL7 gene is very unlikely to influence the genetic susceptibility to MS in this population. 17913246

2007

Entrez Id: 3574
Gene Symbol: IL7
IL7
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker CTD_human Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis. 17660816

2007

Entrez Id: 3574
Gene Symbol: IL7
IL7
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker BEFREE In addition, we report altered expression of the genes encoding IL7Ralpha and its ligand, IL7, in the cerebrospinal fluid compartment of individuals with multiple sclerosis. 17660816

2007