Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.430 Biomarker BEFREE Decreased interferon-β induced STAT-4 activation in immune cells and clinical outcome in multiple sclerosis. 27918083

2017

Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.430 Biomarker CTD_human Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. 24076602

2013

Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.430 GeneticVariation GWASCAT Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. 24076602

2013

Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.430 GeneticVariation GWASDB Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci. 22190364

2011

Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.430 AlteredExpression BEFREE The consistency of the expression levels of STAT6, JAK1, JAK3 and IL-4R between the multiple sclerosis cases suggests an overall activation of the STAT6-signalling pathway in oligodendrocytes, whereas the expression of STAT4 and HLA-DRalpha indicates the activation of pro-inflammatory pathways in microglia. 18056737

2008

Entrez Id: 6775
Gene Symbol: STAT4
STAT4
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.430 Biomarker BEFREE Curcumin has been shown to exhibit an inhibitory effect on the production of inflammatory cytokines by human monocytes and has inhibited the animal model of multiple sclerosis (MS), experimental autoimmune encephalomyelitis (EAE) in association with a decrease in interleukin 12 (IL-12) production and signal transducer and activator of transcription 4 (STAT4) activation. 17979888

2008