Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1719
Gene Symbol: DHFR
DHFR
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.550 Biomarker BEFREE Antimalarial Drug Pyrimethamine Plays a Dual Role in Antitumor Proliferation and Metastasis through Targeting DHFR and TP. 30642883

2019

Entrez Id: 1719
Gene Symbol: DHFR
DHFR
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.550 GeneticVariation BEFREE Also patients homozygous for the G allele of rs1053129 in the dihydrofolate reductase (DHFR) gene were more likely to have a metastasis (45%, P= 0.005), and the methylenetetetrahydrofolate reductase (MTHFR) 677C allele was associated with higher degree of liver toxicity (88%, P=0.007). 25778468

2015

Entrez Id: 1719
Gene Symbol: DHFR
DHFR
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.550 AlteredExpression BEFREE Immunoexpression of TYMS and DHFR were retrospectively assessed in biopsies of 124 consecutive NPC patients without initial distant metastasis and treated with consistent guidelines. 23726796

2013

Entrez Id: 1719
Gene Symbol: DHFR
DHFR
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.550 AlteredExpression BEFREE DHFR and RFC1 expression was lower in initial osteosarcoma biopsy specimens than in metastases (P = .024 and P = .041, respectively). 19159907

2009

Entrez Id: 1719
Gene Symbol: DHFR
DHFR
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.550 Biomarker CTD_human DHFR and RFC1 expression was lower in initial osteosarcoma biopsy specimens than in metastases (P = .024 and P = .041, respectively). 19159907

2009

Entrez Id: 1719
Gene Symbol: DHFR
DHFR
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.550 Biomarker BEFREE Four near-diploid cell lines (LoVo, HCT116, DLD-1 and KM12C) and two aneuploid KM12C-derived metastases (KM12SM and KM12L4A) developed MTX resistance but none exhibited DHFR amplification. 16007155

2005

Entrez Id: 1719
Gene Symbol: DHFR
DHFR
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis
0.550 ModifyingMutation RGD Permissivity for methotrexate-induced DHFR gene amplification correlates with the metastatic potential of rat adenocarcinoma cells. 8149482

1994