Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 Biomarker BEFREE Target delivery selective CSF-1R inhibitor to tumor-associated macrophages via erythrocyte-cancer cell hybrid membrane camouflaged pH-responsive copolymer micelle for cancer immunotherapy. 31704343

2020

Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 Biomarker BEFREE We have shown that in response to tumour-conditioned medium, these cells upregulate CD206 and CD115, markers traditionally associated with M2-type macrophages. 31444606

2019

Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 Biomarker BEFREE Modulating the Tumor Microenvironment via Oncolytic Viruses and CSF-1R Inhibition Synergistically Enhances Anti-PD-1 Immunotherapy. 30527756

2019

Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 AlteredExpression BEFREE We previously reported in classical Hodgkin Lymphoma (cHL) that a member of the THE1B class of LTR elements acted as a promoter for the proto-oncogene and growth factor receptor gene CSF1R and that expression of this gene is required for cHL tumour survival. 30546079

2019

Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 Biomarker BEFREE Importantly, we found that targeting myeloid cells using anti-CSF1R in combination with VTP therapy decreased the number of tumor MDSCs and TAMs, especially M2 macrophages, as well as increased CD8<sup>+</sup> T cell infiltration, decreased tumor growth and improved overall survival. 31069149

2019

Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 Biomarker BEFREE PLX3397, an inhibitor of the colony stimulating factor-1 (CSF-1)/CSF-1 receptor (CSF-1R) pathway and macrophage survival, was delivered to B16F10 tumors via M2pep-modified PLGA nanoparticles. 30859335

2019

Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 Biomarker BEFREE Imaging endogenous macrophage iron deposits reveals a metabolic biomarker of polarized tumor macrophage infiltration and response to CSF1R breast cancer immunotherapy. 30696910

2019

Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 AlteredExpression BEFREE Loss of methylation and associated overexpression of the CSF 1 receptor (CSF1R) was seen in a majority of tumors and was driven by an alternative, endogenous viral promoter in a subset of samples. 30046005

2018

Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 Biomarker BEFREE These findings indicate that depletion of tumor-associated macrophages from neuroblastomas can be associated with increased chemotherapeutic efficacy without requiring a contribution from T-lymphocytes, suggesting the possibility that combination of CSF-1R blockade with chemotherapy might be effective in patients who have limited anti-tumor T-cell responses. 29665011

2018

Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 Biomarker BEFREE Flow cytometry analysis of tumor infiltrating T-cells in a murine model of PDAC was performed to investigate the therapeutic effects and mechanism of anti-CSF-1R/anti-PD-1/GVAX combination immunotherapy. 30424804

2018

Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 Biomarker BEFREE Potential contribution of tumor-associated slan<sup>+</sup> cells as anti-CSF-1R targets in human carcinoma. 28951423

2018

Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 Biomarker BEFREE CSF1R-expressing tumor-associated macrophages (TAMs) induce a tumor-promoting microenvironment by regulating immunity. 30065206

2018

Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 Biomarker BEFREE In many malignancies, the tumor microenvironment includes CSF1R-expressing supportive monocyte/macrophages that promote tumor cell survival. 29872489

2018

Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 Biomarker BEFREE These findings identify CSF1R+ TAMs and PI3Kδ-driven Foxp3+ Treg cells as the dominant compensatory cellular components of the immunosuppressive tumor microenvironment, with implications for the design of combinatorial immunotherapies. 29875321

2018

Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 Biomarker BEFREE Furthermore, a combination of cisplatin and CSF-1R inhibitor effectively inhibited tumour growth in xenografts. 29372560

2018

Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 Biomarker BEFREE Colony-stimulating factor 1 receptor (CSF1R) controls the formation, differentiation and function of M2 macrophages, which helps tumors grow, metastasize and secrete immunosuppressive cytokines. 30149762

2018

Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 Biomarker BEFREE Furthermore, a western blot analysis and the immunohistochemistry results confirmed that the phosphorylation of CSF1R in tumor tissue was dramatically reduced after D2923 treatment, and this was accompanied by the depletion of macrophages in the tumor. 29968849

2018

Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 Biomarker BEFREE Our model was used to investigate the evolutionary kinetics of the tumor regrowth and the associated dynamic adaptation of the tumor microenvironment in response to the CSF1R inhibitor treatment. 29440290

2018

Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 AlteredExpression BEFREE This CSF-1R/c-FMS is over expressed in many cancers and on tumour associated macrophages, consequently, have been exploited as a drug target for promising treatment for cancer and inflammatory diseases. 29679908

2018

Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 AlteredExpression BEFREE Conversely, CSF-1R overexpression enhances cell proliferation and accelerates tumor growth. 28469954

2017

Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 Biomarker BEFREE Combining CSF1R inhibitor with a CXCR2 antagonist blocked granulocyte infiltration of tumors and showed strong anti-tumor effects. 29136508

2017

Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 AlteredExpression BEFREE Conversely, ectopic expression of CSF-1R promoted cells proliferation and accelerated tumor growth. 29218239

2017

Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 Biomarker BEFREE Given the pro-angiogenic properties of tumor-associated macrophages (TAMs) and the dominant role of CSF1R in macrophage function, we added CSF1R inhibitors following emergence of adaptive resistance to anti-VEGF antibody. 29228548

2017

Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 GeneticVariation BEFREE Depletion of Tumor-Associated Macrophages with a CSF-1R Kinase Inhibitor Enhances Antitumor Immunity and Survival Induced by DC Immunotherapy. 28536100

2017

Entrez Id: 1436
Gene Symbol: CSF1R
CSF1R
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.500 GeneticVariation BEFREE Tumor-associated macrophages in surgical specimens and sensitivity to CSF-1R inhibitors were used to determine macrophage function.<b>Results:</b> A <i>CSF1R</i> c.1085A>G genetic variant causing the change of histidine to arginine in the domain of receptor dimerization was identified as a high allele frequency in Eastern Asian population. 28724665

2017