Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Overall, our findings indicate that <i>MIR145-3p</i> exerted a tumor suppression function in MM by inducing autophagic cell death and suggest that <i>MIR145-3p</i>-based targeted therapy would represent a novel strategy for MM treatment. 31242129

2020

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE We observed that the expression level of miR-145 was positively correlated with the tumor differentiation (P = 0.015), lymph node status (P = 0.007), distant metastasis (P = 0.008), and TNM stage (P = 0.033). 31014553

2019

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Versatile protamine nanocapsules to restore miR-145 levels and interfere tumor growth in colorectal cancer cells. 31326581

2019

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE High expression level of miR-21 in the serum was correlated with tumor size, grade of differentiation, invasion, metastasis and clinical stage, and low expression level of miR-145 in the serum was correlated with tumor size, grade of differentiation, invasion, metastasis and clinical stage. 29552756

2019

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Thus, this study identified GBC patient subgroups and provides new mechanistic insights in the tumor suppressive function of miR-145-5p leading to activation of STAT1 signaling. 30886199

2019

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE TUG1 regulated tumor growth (viability and apoptosis) and metastasis through miR-145-5p. 30916820

2019

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE These findings indicate that microRNA-145-5p functions as a novel tumor suppressor through targeting RAB18, suggesting that microRNA-145-5p might be a potential new therapeutic molecule for the treatment of hepatocellular carcinoma. 31106707

2019

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE The melanoma xenograft tumor models were established to determine the biological activity of miR-145-5p in melanoma in vivo. 30701576

2019

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE BL-administration induced the tumor suppressor miRNAs (miR-145 and miR-15a) expression in both of the healthy and in CRC-mice. 30862187

2019

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE We conclude that miR-145 is a potential marker for use in the early diagnosis and prognostic evaluation of patients with cancer, has a role as a tumor suppressor, and is a promising cancer treatment target candidate. 30774425

2019

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Among them, miRNA-145 (miR-145) played a profound role in tumorigenesis and progression of various neoplasms. 31814885

2019

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE circOMA1 promotes NFPA progression by acting as the sponge of tumor suppressor miR-145-5p to regulate the TPT1 signaling pathway, revealing a therapeutic target in preventing the tumorigenesis of NFPAs. 30721952

2019

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Furthermore, our in vivo results showed that overexpression of miR-145 or silencing of lncRNA PVT1 resulted in decreased tumor growth in nude mice. 31369196

2019

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Collectively, the present results suggest that miR‑145 is a tumor suppressor for gastric cancer and it may be a potential therapeutic target for gastric cancer treatment. 30864704

2019

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Importantly, low miR-145-5p expression was correlated with TNM (tumor, node, metastasis) status and metastasis. 30341010

2019

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE <b>Results:</b> MiR-145 inhibited LSCC growth in a dose-dependent manner, as tumor growth was significantly inhibited in mice injected intratumorally with high-dose miR-145 compared with both the untreated and low-dose miR-145 groups (<i>p</i><0.05). 31118798

2019

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE MiR-145 correlated to pT-stage (p = 0.038), tumor size (p = 0.025), Gleason grade (p = 0.051) and PSA (p = 0.032). 30674952

2019

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE In addition, restoration of these 2 genes significantly reversed the tumor suppressive effects of miR‑145. 30864742

2019

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE The pair miR-145/ERG showed an exclusive staining for miR-145 in the nuclei of stromal cells, both in tumor and normal tissue, and for ERG in the cytoplasm with/without co-expression in the nucleus of tumor cells. 31186527

2019

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Oncogenic HBXIP is a new direct target of tumor suppressive miR-145. 30381907

2019

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Tumor suppressor miR-145-5p sensitizes prolactinoma to bromocriptine by downregulating TPT1. 30370446

2019

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Despite several reports describing the dual role of miR-145 as an oncogene and a tumor suppressor in cancer, not much has been resolved and understood. 31516387

2019

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE miR-145-5p has been reported to be downregulated and described functioning as a tumor suppressive gene in colorectal cancer (CRC), yet its detailed regulatory function and mechanism in malignant progression of the disease have not been thoroughly understood. 31693935

2019

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Loss- and gain-of-function experiments as well as a xenograft tumor model were performed to assess the role of circDUSP16 in GC cells. circDUSP16-specific binding with miR-145-5p was confirmed by bioinformatic analysis, luciferase reporter, and RNA immunoprecipitation assays. 31776711

2019

Entrez Id: 406937
Gene Symbol: MIR145
MIR145
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE As a promising alternative to traditional therapies for LSCC, MNP-PLL/miRNA nanoparticles were combined with photothermal ablation against primary tumors and miR-145-5p mediated gene therapy for depleting the metastatic potential of tumor cells. 30882835

2019