Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE The expression level of miR-34a was correlated with tumor cell diameter, lymph node metastasis and histological types of basal cell carcinoma (p<0.001). 31424691

2020

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE The tumor suppressor miR-34a is downregulated in TNBC, and its loss-of-expression correlates with worse disease outcomes. 31742868

2020

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE As a whole, our study confirmed the inhibition of miR-34a in the invasion, proliferation, and migration of the OSCCs, playing a potential tumor suppressor role with SATB2 as its downstream target. 31663131

2020

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE The findings of the present study indicate the tumor suppressive role of miR-34 in ovarian cancer and may therefore prove to be a potential therapeutic target. 30905732

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Although expression levels of miR-34-family miRNAs do not correlate with gender, age, or tumor staging, interestingly they are correlated with smoking status and tumor sites. miR-34b/b*/c are up-regulated in tumors from those who ever smoked or recently smoked (quit smoking less than 15 years ago); but such up-regulation was not seen in those who never smoked or quit smoking for at least 15 years. 30515607

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Epigenetic origin of the link between obesity and breast cancer (BC) is investigated in a cohort of Tunisian patients, focusing on polymorphism at germline level (miR-146a) and on expression in mammary tumors (miR-21, miR-146a, and miR-34a), according to body mass index (BMI) and clinico-pathologic features. 30303554

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE In addition, the expression of miR‑34a, a well‑known tumor suppressor was revealed to be inversely correlated with COUP‑TFII expression. 30968145

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE The microRNA miR-34a is a tumor suppressor transcript, and its loss has been prominently linked to various human cancers, including malignancies of the brain. 30488149

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Moreover, miR‑34 has been identified as a tumour‑suppressor in GC. p53‑induced miR‑34 regulates several different target genes and signalling pathways, inducing apoptosis, senescence, and cell cycle arrest and repressing GC cell proliferation, migration and metastasis, thus contributing to the suppression of carcinogenesis and GC cancer progression. 31432176

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Knocking down of sONE resulted in a marked decrease in TP53 and increase in c-Myc and consequently altering the expression status of their downstream tumor suppressor microRNAs (miRNAs) such as miR-34a, miR-15, miR-16, and let-7a. 30968427

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Tumor suppressor miR-34a was induced upon MCT-1 knockdown that inhibited IL-6R expression and activated M1 polarization. 30885232

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE For example, ectopic expression of microRNA-34a (miR-34a), a tumor suppressor gene that is a direct transcriptional target of p53 and thus is reduced in p53 mutant tumors, has clear effects on cell proliferation and survival in murine models of cancer. 31258013

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Despite the fact that, due to small sample size, our results should be considered as preliminary, our study suggests that miR-34a is associated with tumor burden and can be important for health-related quality of life, functional status, and mood symptoms of glioblastoma patients. 30836600

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Mounting evidence has shown that miR-34a is a master tumor suppressor miRNA in cancer. 30243731

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE While there is significant downregulation of tumor suppressor microRNA-34a (miR-34a), which targets many oncogenes related to proliferation, apoptosis, and invasion, high expression level of Polo-like kinase 1 (PLK1) is closely associated with short survival rates of pancreatic cancer patients. 30933478

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Furthermore, the Gd-HM-Dox/34a exhibited augmented accumulation in the tumor tissue, which improved the magnetic resonance (MR) imaging contrast of solid tumors and enhanced the combined efficiency of chemotherapeutic drugs Dox and therapeutic gene miR-34a in suppressing tumor growth on MDA-MB-231 tumor-bearing mice. 31684723

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE HMGA2 knockdown or miR-34a-5p overexpression inhibited tumor growth and enhanced TMZ-mediated anti-tumor effect in glioma xenograft models. 30851271

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE MiR-34a acts as a tumor suppressor in various malignancies. 28485160

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE However, miR-34b/c suppressed tumor growth more than miR-34a. 30700696

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Notably, LCC-09-mediated anti-GBM/GSC activities were associated with the re-expression of tumor suppressor miR-34a and reversal of TMZ-resistance, in vitro and in vivo. 31561595

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE MicroRNA-34a (miR-34a) serves as a tumor suppressor in a number of different types of cancer. 31612063

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Although many attentions have been gained, novel biomarkers for NB diagnosis and prognosis are still needed. microRNAs (miRNAs) played important roles in NB progression and miR-34a is a tumor suppressor in NB. 30716314

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE By simultaneous targeting of 14 mRNAs miR-34a acts as major hub of T cell regulatory networks suggesting to utilize miR-34a as target of intervention towards a modulation of the immune responsiveness of T-cells in a broad tumor context. 31311583

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Using the clinical outcome prediction database, low expression of <i>SLIT3</i> was found to be a prognostic predictor of poor survival in urothelial cancer, and a novel miRNA, miR-34a-5p, was a potential regulator of <i>SLIT3</i>, which may infer the potential role of miR-34a-5p-<i>SLIT3</i> regulation in the altered tumor microenvironment in UTUC. 30662333

2019

Entrez Id: 407040
Gene Symbol: MIR34A
MIR34A
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE The role of the tumour-suppressor miR-34 family in breast physiology and in mammary stem cells (MaSCs) is largely unknown. 30093634

2019