Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE We speculate that in PP anetodermic change caused by MMP and elastases including MMP-9 and MMP-12 may precede elimination of the tumor. 31677179

2020

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE To conclude, MMP-9 can be used as a possible target in these tumors as an adjuvant therapy to minimize recurrence rates. 30358613

2020

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Meanwhile, compared with ZHX2 group, the tumor growth rate, volume, weight, the percentage of PCNA-positive cells, and p-P38 MAPK/P38 MAPK were increased significantly in ZHX2 + Ani group, while the apoptotic index and the expression of MMP-9 protein were significantly decreased (p< 0.05). 31683461

2020

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Clinical significance of plasma MMP-2 and MMP-9 levels as biomarkers for tumor expression in breast cancer patients in Egypt. 31820313

2020

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Given that matrix metalloproteinases 9 (MMP9) and its associated vascular endothelial growth factor (VEGF) are critical for tumor vascularization and invasion under castration-resistant condition, it is therefore of great importance to define the functional association and interplay between androgen receptor (AR) and MMP9 and their associated key survival and invasion pathways in PCa cells. 31381135

2020

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Hence, although higher MMP9 expression could give rise to an increased tumour growth in vivo due to increased proliferation, in some circumstances, it may participate in yet unidentified molecular mechanisms that reduce the cell movement in OTSCC. 30710501

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE We conclude that NOX4-mediated mtROS signaling increases MMP9 mRNA stability and affects cancer invasiveness but not tumor growth. 30281903

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Moreover, the levels of MMP-9 were significantly increased in larger tumor size (T3/T4) (p < 0.05) as compared to smaller size (T1/T2), which suggests that MMP-9 plays an important role in the progression of breast cancer. 30993496

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE The results showed that CDK7/9 were highly expressed in UM cells, and SNS-032 significantly suppressed the cellular proliferation, induced apoptosis, and inhibited the outgrowth of xenografted UM cells and PDX tumors in NOD-SCID mice, repressed the cancer stem-like cell (CSC) properties through transcriptional inhibition of stemness-related protein Krüppel-like factor 4 (KLF4), inhibited the invasive phonotypes of UM cells through matrix metalloproteinase 9 (MMP9). 31526394

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Thrombospondin-2 (THBS2), matrix metalloproteinase 2 (MMP2), MMP9 and extracellular matrix (ECM) component expression levels were evaluated, and the growth of xenograft tumors formed following injection of SiHa cells with knockdown of <i>miR-1246</i> was assessed. 31404330

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE SIGNIFICANCE STATEMENT: The expression of the enzyme NAT1 was found to be negatively correlated with MMP9 expression in tumor tissue from breast cancer patients. 31444237

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Silencing the α7-nAChR reduced the viability of HCC cells, suppressed cellular proliferation, attenuated migration and invasion, and diminished the tumor's sphere-formation ability, with concurrent downregulation of expression levels of the TGR5, p-JAK2, p-STAT3 (Tyr705/Ser727), RhoA, ROCK1, MMP2, and MMP9 proteins. 31492006

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE MMP-9 expression was more significant in tumor stroma than in the perimatrix of the mucous membrane (<i>p</i> = 0.047). 31143300

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Compared with the control group, the tumor tissues from mice in the LOX inhibition group had reduced relative expression levels and enzyme activities of MMP-2 and MMP-9 (P < 0.05). 31777578

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Finally, the in vivo experiment revealed that miR-26b mimic transfection strongly reduced the tumor growth, tumor volume, and expression of matrix metalloproteinase-2 (MMP-2) and MMP-9. 28800785

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE MMP-9 is involved in the shedding of sMICA from MICA to promote tumor immune escape. 30458325

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Mouse lymphoma tissues were extracted, and the expressions of MMP-9 and Bcl-2 messenger ribonucleic acids (mRNAs) in the xenograft tumor were detected using Real-time polymerase chain reaction (PCR). 30779087

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Since MMP9 has been linked with rapid metastasis and tumor aggression in humans, the data in this study offer a possible mechanism of aggression in HM. 31011867

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE In addition, chronic stress increased the expression of VEGF, MMP-2, MMP-7 and MMP-9 in transplanted tumour tissue, and catecholamine hormones enhanced the expression of metastasis-related proteins. 31624248

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Luteolin suppressed the expression of matrix metalloproteinase-9 and inhibited migration and invasion in MDA-MB-231 cells treated with the tumor promotor 12-O-tetradecanoylphorbol-13-acetate at non-cytotoxic concentrations (0, 5, and 10 μM). 31611756

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE Compared with the saline control, MATT-LTSLs exhibited enhanced accumulation in the tumor and a 20-fold decrease in tumor growth in 4T1 tumor-bearing mice; moreover, MATT-LTSLs reduced MMP-2 and MMP-9 activity by 50% and 43%, respectively, and downregulated MMP-2 and MMP-9 expression in vivo by 30% and 43%, respectively. 31637006

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE In this study, we address this dilemma by developing an enzyme-responsive zwitterionic stealth peptide coating capable of responding to matrix metalloproteinase-9 (MMP-9) which is overexpressed in tumor microenvironment. 30660006

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker BEFREE Furthermore, elevated miR-143 or exosome-miR-143 or silencing TFF3 inhibited the expression of TFF3, proliferating cell nuclear antigen (PCNA), matrix metalloproteinase (MMP)-2, and MMP-9 and PC3 cell proliferation, migration, invasion, and tumor growth, whereas it promoted apoptosis. 31563120

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE CA can act by preventing the production of ROS (reactive oxygen species), inducing DNA oxidation of cancer cells, as well as reducing tumor cell angiogenesis, blocking STATS (transcription factor and signal translation 3) and suppression of MMP2 and MMP-9 (collagen IV metalloproteases). 31293975

2019

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression BEFREE MMP-2 and MMP-9 levels were not correlated with grade or stage of the tumor. 30548095

2019