Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE The changes in tumor volume, adverse reactions and survival of patients in the TP group and rAd-p53 + TP group, and the levels of p53, ASPP2, inhibitory member of the ASPP family (iASPP) and P-gp in postoperative tumor tissues in the 3 groups were evaluated. 31424649

2020

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE Despite this achievement, general principles from proposed systems pharmacokinetic modeling for intracellular processing of ADCs indicate potential shortcomings of T-DM1: (i) <i>C</i><sub>max</sub> limited by toxicities; (ii) slow internalization rate; (iii) resistance mechanisms due to defects in intracellular trafficking [loss of lysosomal transporter solute carrier family 46 member 3, (SLC46A3)], and increased expression of drug transporters MDR1 and MRP1; and (iv) lack of payload bystander effects limiting utility in tumors with heterogeneous HER2 expression. 31582515

2020

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE Here, we show that competitive inhibition of MDR1 restored sensitivity to BV in our BV-resistant cell lines by increasing intracellular MMAE levels, and potentiated BV activity in BV-resistant HL tumors in a human xenograft mouse model. 31811017

2020

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE In addition, NO has other multiple synergistic cancer treatment functions, including tumor tissue vasodilatation for drug extravasation promotion, P-glycoprotein (P-gp) downregulation for drug efflux inhibition, and glutathione depletion for cancer cell endogenous antioxidant defense destruction. 31804837

2020

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE Moreover, the expression of P-glycoprotein (P-gp) was suppressed to overcome tumour MDR. 31026507

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE These may include increased production of tumor resistance conferring proteins such as multidrug resistance (MDR-1) and myeloid cell leukemia (MCL-1). 30452910

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 GeneticVariation BEFREE In this study, a plasmid DNA which expressed small hairpin RNA of PD-L1 (shPD-L1) was loaded in the ultrasensitive pH triggered charge/size dual-rebound P[(GP)D] nanoparticles (NPs) to silence the PD-L1 gene for reducing the PD-L1/PD-1 interactions between tumors and T cells. 30476528

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Overexpression of P-glycoprotein (P-gp) is a significant cause for tumor MDR. 31441108

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE As expected, tumors treated by free doxorubicin hydrochloride (DOX·HCl) showed obvious increase of P-glycoprotein, while for tumors treated by nanocarrier encapsulated doxorubicin, the P-glycoprotein level stayed low as untreated group. 30471372

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE ABCG2/ABCB1 ratios in surgically resected tumor tissue (1.4 ± 0.2) were comparable to previously reported ABCG2/ABCB1 ratios in isolated human micro-vessels (1.3), which suggested that no overexpression of ABCB1 or ABCG2 occurred in the investigated tumors. 31832814

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Specifically, hydrophilic anticancer irinotecan (Ir) and hydrophobic P-gp protein inhibitor quinine (Qu) are linked by a redox responsive bridge for overcoming MDR of tumors. 31534517

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 GeneticVariation BEFREE Patients with "CT/TT" genotypes (response rate: 83.3%) of ABCB1 (C1236T) gene showed better tumour response than those with "CC" genotype (response rate: 16.6%) [OR = 2.94 (CI: 1.15-7.52); P = 0.03]. 30637776

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE [<sup>18</sup>F]AVT-011 is a dual ABCB1/ABCG2 substrate radiotracer that can quantify transporter function at the blood-brain barrier and in ABCB1-expressing tumors, making it potentially suitable for clinical imaging of ABCB1-mediated MDR in tumors. 31729540

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE Due to the high oxygen capacity of such nanoparticles, the hypoxic tumor microenvironment was greatly modulated after these nanoparticles reached the tumor region, and the results revealed that hypoxia-inducible factor α (HIF-1α) was down-regulated and the expression of P-glycoprotein (P-gp) was then reduced, which were in favor of chemotherapy. 31293763

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Although dietary ellagic acid did not alter the tumor growth inhibition by docetaxel of xenografted 22Rv1 cells, ellagic acid has the potential to interfere with taxane chemotherapy by reducing tubulin polymerization while inhibiting P-glycoprotein drug efflux. 30867440

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Intracellular Doppler Spectroscopy detects altered drug response in SKOV3 tumor spheroids with silenced or inhibited P-glycoprotein. 31103263

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE P-glycoprotein (P-gp) is an important determinant of multidrug resistance (MDR) because its overexpression is associated with increased efflux of various established chemotherapy drugs in many clinically resistant and refractory tumors. 31640190

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Our study demonstrates significant differences in lung tumor detectability on chest radiographs between PGY-1 trainees and pulmonary specialists according to tumor size, extent of GGO, and tumor location. 30266280

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE Three members of ABC transporters superfamily, P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and ABCB5 were investigated, whose overexpression in tumors is tightly linked to multidrug resistance. 31132750

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE Overexpression of P-gp in tumor cells is a major obstacle in cancer chemotherapy. 30270513

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Furthermore, HDAC1 silencing by Panobinostat and/or lentivirus mediated RNA interference against HDAC1 effectively reduced doxorubicin resistance, resulting in the inhibition of tumor growth in AML bearing mice. 31358016

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE Western blot and polymerase chain reaction analyses showed that inhibition of P-glycoprotein and X-linked inhibitor of apoptosis protein expression may underlie inhibition of tumor resistance mediated by NPs. 31141733

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE Xenograft tumor experiment was conducted to confirm the association between TET1 and P-gp expression under gemcitabine chemoresistance. 30784212

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE As a major clinical tumor chemotherapeutic burden, multidrug resistance (MDR) is often a result of up-regulation of P-glycoprotein (P-gp), which strongly enhances anticancer drug efflux. 31465208

2019

Entrez Id: 5243
Gene Symbol: ABCB1
ABCB1
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE Hypermethylation of the analyzed ABCB1 promoter region was significantly correlated with low levels of the ABCB1 transcript in tumors from a subset of patients with breast and ovarian carcinoma prior to chemotherapy but not following treatment. 31173253

2019