Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 GeneticVariation BEFREE Moreover, ectopic expression of Myr-Akt1 or phosphomimetic HK2-T473D rescued cisplatin-induced tumor suppression in Skp2 knockdown stable cells. 31435020

2019

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE More than a half of the tumors had low immunoexpression of Skp2 and Cks1, and high and moderate p27 and Ki67 expression. 29135092

2019

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Resistance to PI3K inhibitors correlated with the increased abundance of Skp2, ubiquitylation of AKT, cell proliferation in culture, and xenograft tumor growth in mice. 29535262

2018

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE Our data showed that SKP2 levels were significantly increased in HCC cell lines and HCC tissues rather than corresponding normal liver tissues, and augmented SKP2 levels were statistically correlated with tumor grade, size and metastases. 29991055

2018

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE In histology subgroup analysis, differences in Skp2 protein expression were observed in patients with LUAD, based on sex, differentiation, smoking history, stage, lymph node metastasis and tumor diameter (P<0.05), but not in patients with LUSC except for smoking status. 30127874

2018

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE Transcript expression of SKP2, a SCF<sup>SKP</sup> component, was elevated in RB1-defective TNBCs, suggesting that in these tumours, SKP2 activity might buffer the effects of RB1 dysfunction. 29915391

2018

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE The present results revealed that genistein exerted its tumor suppressor effect at least partially via inhibition of Skp2 and promotion of its downstream targets p21 and p27. 29434697

2018

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Skp2 (Fbxl1) directly binds to the tumor suppressor p27 in the context of the SCF<sup>Skp2</sup> E3 ubiquitin ligase to ubiquitylate and target-phosphorylated p27 for proteasomal degradation. 30108998

2018

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE In a xenograft mouse model implanted with PC-3-Pa cells, LJ-2618 (3 or 10 mg/kg) effectively inhibited tumor growth with the enhancement of Skp2 degradation and induction of p27 expression in tumor tissues. 30292755

2018

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Mechanistic studies revealed that G0/G1 arrest and tumor senescence upon pulsed T treatment were associated with a marked decrease in cyclin D1, c-Myc and SKp2, CDK4 and p-Rb levels and upregulation of p27 and p-ERK1/2. 29371946

2017

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE 6-OAP inhibited tumor growth in SCID mice intravenously injected with lung cancer cells, and downregulated both STAT3 and Skp2 in tumor samples. 27835873

2017

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Finally, we describe how the MYC/CDK2/p27/SKP2 axis impacts on tumor development and discuss possible ways to interfere therapeutically with this system to improve cancer treatment. 28665315

2017

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE High p53-, phospho (p)-Rb-, SKP2-, cyclin D1-, and p-c-myc-positive rates were correlated with HPV-negative tumors, whereas high p16- and p27-positive rates were associated with HPV-positive tumors. 28627689

2017

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Collectively, our data show that the β-TrCP-FBXW2-SKP2 axis forms an oncogene-tumour suppressor-oncogene cascade to control cancer cell growth with FBXW2 acting as a tumour suppressor by promoting SKP2 degradation. 28090088

2017

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE S-phase kinase-associated protein 2 (SKP2) (also known as FBXL1) is often overexpressed in human cancers, and functions as an oncogenic E3 ligase to degrade tumor suppressor gene products. 26560120

2016

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE Tumor samples were collected to examine the association between the expression of S-phase kinase-associated protein 2 (SKP2) and prognosis in cervical cancer. 27317767

2016

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Noticeably, the tumor suppressor proteins whose levels have been shown to be downregulated by SKP2-dependent degradation in various tumor types, including p27, p57, Dusp1, and Rassf1A were not decreased in liver lesions from SKP2/N-RasV12 and SKP2/myr-AKT1 mice. 25537506

2015

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE S phase kinase-associated protein 2 (Skp2) has been shown to be required for spontaneous tumor development that occurs in the retinoblastoma protein (pRb) deficient mice. 26497688

2015

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE The results established a paradigm whereby systemic Akt1 inhibition is sufficient to regress tumors that are not driven by Akt activation and a mechanism of cell survival by Skp2. 26190111

2015

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE Overexpression of Skp2 and loss of CDKN1B (p27) was strongly associated with aggressive tumor behavior and poor clinical outcome in a variety of cancers, including colorectal cancer. 26114183

2015

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE The expression of p27, Skp2, and p-p27 (Thr187) was closely associated with tumor grade and TNM stage (P < 0.05). 25663461

2015

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE IHC showed SKP2 to be more highly expressed in estrogen receptor α (ERα)-negative breast cancers and demonstrated that triple-negative tumors were more likely to have high expression of SKP2 than were non-triple negative, ERα-negative tumors. 24443386

2014

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE This reciprocal regulation between DAB2IP and Skp2 protein represents a unique homeostatic balance between tumor suppressor and oncoprotein in normal prostate epithelia, which is apparently altered in cancer cells. 25115390

2014

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Furthermore, we found that depletion of Skp-2 caused a dramatic cell cycle arrest, followed by massive apoptotic cell death, and eventually resulted in a significant decrease in growth, viability and tumor formation in renal cancer cell lines studied. 25120761

2014

Entrez Id: 6502
Gene Symbol: SKP2
SKP2
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE Xenograft mice with galectin-3-depleted gastric cancer cells display tumor growth retardation that is reversed by Skp2 overexpression. 24971481

2014