Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Sensitive measurement of tumor markers somatostatin receptors using an octreotide-directed Pt nano-flakes driven electrochemical sensor. 31816809

2020

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE As GEP-NENs express somatostatin receptors (SSTRs), long-acting somatostatin analogs (SSAs) that are used for secretory syndrome and tumor control may lead to altered glucose metabolism. 31839442

2020

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE <b>Conclusion:</b> [<sup>55</sup>Co]Co-DOTATATE demonstrated superior image contrast compared to [<sup>64</sup>Cu]Cu-DOTATATE and [<sup>68</sup>Ga]Ga-DOTATATE for PET imaging of somatostatin receptor expressing tumors, warranting translation into clinical trials. 31519803

2020

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Peptide receptor radionuclide therapy (PRRT) is among the most effective therapeutic options for metastatic NETs because of targeted delivery of radioactivity to the tumour via the somatostatin receptor (SSTR) and relatively low systemic toxicity. 31492995

2020

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Somatostatin analogs regulate tumor corticotrophs growth by reducing ERK1/2 activity. 30611770

2019

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE Both everolimus and pasireotide inhibit the growth of thyroid cancer cell lines in vitro with varied efficacy that correlates with tumor origin and somatostatin receptor (SSTR) expression profile of the cell lines. 30807575

2019

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 GeneticVariation BEFREE The high expression of somatostatin receptor 2 (SST2) in growth hormone (GH)-secreting tumors represents the rationale for the clinical use of somatostatin analogs (SSAs) in acromegaly. 31574507

2019

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Similarly to what was observed in the major ampulla, 3 histotypes were found: (i) ampullary-type somatostatin-producing tumors (ASTs, 10 cases), characterized by somatostatin expression in most tumor cells, focal-to-extensive tubulo-acinar structures, often with psammoma bodies, MUC1 reactivity, and no or rare membranous reactivity for somatostatin receptor type 2A; (ii) gangliocytic paragangliomas (3 cases), characterized by the coexistence of 3 tumor cell types: epithelioid, often reactive for pancreatic polypeptide, ganglion-like cells, and S100 reactive sustentacular/stromal cells; and (iii) ordinary nonfunctioning NETs (3 cases), resembling those more commonly observed in the extra-ampullary duodenum. 30913089

2019

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Here, we report a patient with an highly aggressive, dopamine-resistant prolactinoma, who only achieved biochemical and tumor control during pasireotide long-acting release (PAS-LAR) therapy , a second-generation somatostatin receptor ligand (SRL). 31167168

2019

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Tumor specimens of all included patients (n = 8) before and after the onset of a therapy with somatostatin analogs were analyzed and a micro-RNA expression profile (754 micro-RNAs) of each probe was generated. 31196127

2019

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Prognostic value of somatostatin receptor expressing tumor volume calculated from <sup>68</sup>Ga-DOTATATE PET/CT in patients with well-differentiated neuroendocrine tumors. 31350603

2019

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE Although heterogeneous in presentation, a common denominator among these tumors is the overexpression of somatostatin receptors. 31058910

2019

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE This overexpression provides a molecular basis for tumor imaging and treatment with somatostatin analogs. 30657933

2019

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE In poorly differentiated neuroendocrine tumours or medullary thyroid carcinoma, 18F-fluorodeoxyglucose PET/CT and dihydroxyphenylalanine PET/CT play an important role due to the limitations of the somatostatin receptor imaging in these tumour entities. 30852831

2019

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE Patients with stable disease were characterized by a combination of both a high uptake on <sup>111</sup>In-DTPA-octreotide scan (uptake grade ≥ 3) and a positive somatostatin receptor type 2a (SSTR2a) expression of the tumor by immunohistochemistry. 30953466

2019

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Mice bearing CA20948 somatostatin receptor positive tumor xenografts were treated with <sup>177</sup>Lu-DOTATATE or sham-treated, and co-injected with <sup>111</sup>In-anti-γH2AX-TAT, <sup>111</sup>In-IgG-TAT control, or vehicle. 31757844

2019

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 AlteredExpression BEFREE Somatostatin receptors (SSTR) are upregulated in the cells of origin that define numerous neuroendocrine neoplasms. 31121520

2019

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Using the established clinical efficacy of radiolabeled somatostatin analogs as a model, we demonstrate the ability of a fluorescent somatostatin analog to selectively target tumors that overexpress somatostatin receptor subtype-2 (SSTR2) and demonstrate utility for fluorescence-guided surgery (FGS). 31015345

2019

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Ga-DOTATATE is a radiolabeled somatostatin analog used for the detection and characterization of somatostatin receptor (SSR)-overexpressing tumors, particularly well-differentiated neuroendocrine tumors. 30688738

2019

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE In accordance with the current consensus criteria, we recommend pasireotide LAR monotherapy as a second-line therapy in young patients who show tumor growth during first-generation somatostatin receptor ligand (SRL) therapy and in patients who show tumor growth during PEGV therapy. 30608534

2019

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Seventeen ileal NET patients and 36 pancreatic NET patients who underwent surgical resection between 2001 and 2018, who had pathology-confirmed liver metastases and confirmed tumor somatostatin receptors, did not have MEN-1, and had no previous treatment were identified. 31346887

2019

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE It has been shown that the expression of somatostatin receptors in the tumor might be of importance to select patients who could benefit from treatment with somatostatin analogues. 31569719

2019

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Twelve studies on the use of somatostatin receptor PET/CT in detecting CUP-NETs in 383 metastatic patients were included. 31004334

2019

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE Somatostatin receptor imaging has previously been performed with a gamma camera using [<sup>111</sup>In]In or [<sup>99m</sup>Tc]Tc-labelled compounds, while [<sup>68</sup>Ga]Ga-labelled compounds and PET/CT imaging has recently become the gold standard for the diagnosis and management of these tumors. 31337043

2019

Entrez Id: 6750
Gene Symbol: SST
SST
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.400 Biomarker BEFREE We hypothesised that TAF-derived cytokines may play a role in tumour aggressiveness, and that their release can be inhibited by somatostatin analogues. 31645017

2019