Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker BEFREE Taken together, our findings suggested that CAI2 contributes to the paradoxical overexpression of p16 in neuroblastoma, where CAI2 may offer a useful biomarker of high-risk disease. 25028366

2014

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker BEFREE Molecular targeting of neuroblastoma with a novel p16INK4a transporter system. 24714808

2014

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression BEFREE Intriguingly, analyses utilizing chromatin immunoprecipitation revealed different histone mark-defined epigenetic activity states of p14(ARF) in neuroblastoma cell lines that correlated with endogenous p14(ARF) expression but not with episomal p14(ARF) promoter reporter activity, indicating that the native chromatin context serves to epigenetically repress p14(ARF) in neuroblastoma cells. 23343716

2013

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 PosttranslationalModification BEFREE The aim of this study was to evaluate the role of p16 and its methylation pattern in neuroblastoma tumorigenesis. 19466588

2010

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 GeneticVariation LHGDN Chromosome 9p, especially the gene CDKN2A, is subject to homozygous (four cases) and heterozygous deletions (five cases) in neuroblastoma tumors. 18664255

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 PosttranslationalModification BEFREE Sixty-two NBs (45 primary tumors and 17 NBs at relapse) were studied in terms of the methylation status of 19 genes (p15INK4a, p16INK4a, p14ARF, APC, RB1, RASSF1A, BLU, FHIT, RARbeta, INI1, TIMP3, NF2, MGMT, DAPK, FLIP, ECAD, CASP8, and the receptors DcR1 and DcR2). 17570703

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 GeneticVariation BEFREE Chromosome 9p, especially the gene CDKN2A, is subject to homozygous (four cases) and heterozygous deletions (five cases) in neuroblastoma tumors. 18664255

2008

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker BEFREE In this study, we report the discovery of a novel variant of p16(INK4A), termed p16gamma, in a primary T-cell acute lymphoblastic leukemia (T-ALL) patient sample and a neuroblastoma cell line, which was expressed at both the transcriptional and translational levels. 17486064

2007

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 GeneticVariation BEFREE Impact of E27X, a novel CDKN2A germ line mutation, on p16 and p14ARF expression in Italian melanoma families displaying pancreatic cancer and neuroblastoma. 16893909

2006

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression BEFREE We show that p19INK4d is the only INK4 protein whose expression is induced by UV light in neuroblastoma cells. 15750620

2005

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker CTD_human Loss of heterozygosity at the Ink4a/Arf gene locus was observed in 5/5 malignant gliomas and 1/1 neuroblastoma, while the PTEN(phosphatase and tensin homologue) gene locus was unaffected by deletions. 15814359

2005

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression BEFREE We concluded that the paradoxical expression of CDKN2A in neuroblastoma cannot be explained by inactivation of the tumor-suppressor gene CDKN1B or overexpression of the oncogene ID2. 15390183

2004

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker BEFREE Homozygous deletions and mutations are not involved in the inactivation mechanism of the CDKN2B/p15 and CDKN2A/p16 genes in neuroblastoma; however, these two abnormalities do not exclude other inactivation pathways. 15517085

2004

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker BEFREE These findings suggest an important role of p14ARF gene in the tumorigenesis of NB. 12963998

2003

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker BEFREE Homozygous deletion of CDKN2A (p16INK4a/p14ARF) but not within 1p36 or at other tumor suppressor loci in neuroblastoma. 11212268

2001

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression BEFREE Taken together, these findings suggest that up-regulated p16 expression may represent a unique feature of aggressive neuroblastoma. 11705866

2001

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 GeneticVariation BEFREE No mutations to the p16-binding site of CDK4 and CDK6 nor any mutations to the coding region of p16 itself were identified in neuroblastoma cell lines. 9935245

1999

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 GeneticVariation BEFREE Differentiation between benign and malignant tumors of the adrenal cortex was attempted by microdissection of nine cases of adrenal cortical hyperplasia, 10 cortical adenomas, and 18 adrenal cortical carcinomas with subsequent polymerase chain reaction (PCR) amplification for loss of heterozygosity (LOH) of five microsatellites of putative tumor suppressor gene loci: p53 gene (17p), the neuroblastoma candidate gene (1p), the p16 gene (9p), the von Hippel Lindau gene (3p), and the retinoblastoma gene (13q). 9596277

1998

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 PosttranslationalModification BEFREE These results indicate that inactivation of the p16 gene is involved in the progression of neuroblastoma independently of N-myc amplification. 9872329

1998

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker BEFREE Disruption of the cyclin D/cyclin-dependent kinase/INK4/retinoblastoma protein regulatory pathway in human neuroblastoma. 9635589

1998

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 GeneticVariation BEFREE This result suggests the presence of at least one other tumor suppressor gene at 9p21, apart from the p16 and p15 genes, which may be of importance to the development of neuroblastoma. 9216721

1997

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 GeneticVariation BEFREE Because the commonly deleted regions at 9p21 includes the p16 (CDKN2A) gene, the status of the p16 gene was further examined in 80 fresh tumors and 19 cell lines of neuroblastoma. 9041193

1997

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 GeneticVariation BEFREE We conclude that the common pattern of p16 inactivation by homozygous deletion or mutation does not seem to be relevant to the development of neuroblastomas. 9115582

1997

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker BEFREE We conclude that (1) neither p16 nor p18 are likely involved in the pathogenesis of neuroblastoma; and (2) the role of p16, or another 9p21 gene, in the development of drug resistance warrants further investigation. 8665486

1996

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker BEFREE Molecular analysis of the cyclin-dependent kinase inhibitor family: p16(CDKN2/MTS1/INK4A), p18(INK4C) and p27(Kip1) genes in neuroblastomas. 8630967

1996