Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker BEFREE E6-Associated Protein Dependent Estrogen Receptor Regulation of Protein Kinase A Regulatory Subunit R2A Expression in Neuroblastoma. 28214999

2018

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 PosttranslationalModification BEFREE The purpose of our study was to investigate the effects of estrogen receptor (ER)-α36 gene silencing on tau protein phosphorylation, cell proliferation, and cell apoptosis in human neuroblastoma SH-SY5Y cells. 29932870

2018

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker BEFREE Further examination revealed that infection with ERA-N273/394-G333 induces IFN-β and CXCL10 mRNA expressions more strongly than ERA-G333 infection in a neuroblastoma cell line. 28882441

2017

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker CTD_human Transcription factor activity of estrogen receptor α activation upon nonylphenol or bisphenol A treatment enhances the in vitro proliferation, invasion, and migration of neuroblastoma cells. 27366082

2016

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker BEFREE Estrogen receptor α regulates non-canonical autophagy that provides stress resistance to neuroblastoma and breast cancer cells and involves BAG3 function. 26158518

2015

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression BEFREE Estrogen receptor-mediated transcription involves the activation of multiple kinase pathways in neuroblastoma cells. 24121066

2014

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker BEFREE Differential regulation of apoptosis-associated genes by estrogen receptor alpha in human neuroblastoma cells. 23271418

2013

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression BEFREE MYCN-regulated microRNAs repress estrogen receptor-alpha (ESR1) expression and neuronal differentiation in human neuroblastoma. 20080637

2010

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker BEFREE Ginsenoside Rg1 protects against 6-OHDA-induced neurotoxicity in neuroblastoma SK-N-SH cells via IGF-I receptor and estrogen receptor pathways. 19476546

2009

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker BEFREE Therefore, we analyzed the binding of [3H]-diprenorphine in human neuroblastoma cells stably transfected with the estrogen receptor cDNA (SK-ER3 cell line). 9892851

1999

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker BEFREE To evaluate the role of estrogen receptor in the differentiation of cells of neural origin, we developed a molecular approach aimed at the identification of estrogen target genes by mRNA differential display PCR (ddPCR) in human neuroblastoma SK-ER3 cells. 9169520

1997

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker BEFREE Neurotransmitters activate the human estrogen receptor in a neuroblastoma cell line. 9328204

1997

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression BEFREE The finding that, in neuroblastoma cells, selected signal transduction systems are involved in the insulin-dependent activation of estrogen receptor is of particular interest considering that estrogen receptor might restrict the role played by insulin during the differentiation of neural cells and interfere with its proliferative potential while allowing its regulation of other functions related to cell survival. 8732681

1996

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 Biomarker BEFREE In order to assess the neuronal-like properties of a human neuroblastoma cell line obtained by stable transfection of the estrogen receptor (SK-ER3) a series of quantitative measurements of the activity of two neurotransmitter-related enzymes: tyrosine hydroxylase (TH) and monamine oxidase (MAO), and of catecholamine concentrations were performed. 7903862

1993

Entrez Id: 2099
Gene Symbol: ESR1
ESR1
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.400 AlteredExpression BEFREE The lack of model systems in which these phenomena could be studied prompted us to develop a neuroblastoma cell line expressing the estrogen receptor. 8475123

1993