Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 AlteredExpression BEFREE The results also establish that LIN28B overexpression supports neuroblastoma onset and the metastatic potential of malignant cells through let-7a-dependent and let-7a-independent mechanisms. 31601998

2020

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 AlteredExpression BEFREE By this study, a regulatory loop is proposed, wherein, ODC silencing in Y79 cells to result in decreased polyamine levels, thereby, leading to altered protein levels of Lin28b, MMP-2 and MMP-9, which falls in line with earlier studies in neuroblastoma. 29241071

2018

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 GeneticVariation BEFREE We also found that the combination of polymorphisms in CASC15, LIN28B, and LMO1 may be used to predict neuroblastoma risk (AUC=0.63, 95% CI=0.59-0.67). 29024823

2017

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 GeneticVariation GWASCAT Common variants upstream of MLF1 at 3q25 and within CPZ at 4p16 associated with neuroblastoma. 28545128

2017

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 GeneticVariation BEFREE With the purpose to evaluate the association between LIN28B gene polymorphisms and neuroblastoma susceptibility in Southern Chinese population, we conducted this study with 256 neuroblastoma cases and 531 cancer-free controls. 27021521

2016

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 Biomarker BEFREE Here we show, however, that LIN28B is dispensable in MYCN-amplified neuroblastoma cell lines, despite de-repression of let-7. 27383785

2016

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 AlteredExpression BEFREE We show that MYCN regulates LIN28B expression in neuroblastoma tumors via two distinct parallel mechanisms. 26123663

2015

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 AlteredExpression BEFREE In vitro experiments using NB cell lines, BE(2)-C, SMS-KCNR, and CHLA90 show that DFMO treatment reduced LIN28B and MYCN protein levels and increased Let-7 miRNA and decreased neurosphere formation. 25415050

2015

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 GeneticVariation BEFREE In a genome-wide association study, we identified single-nucleotide polymorphisms (SNP) associated with neuroblastoma at the CASC15, BARD1, LMO1, DUSP12, HSD17B12, HACE1, and LIN28B gene loci, but these explain only a small fraction of neuroblastoma heritability. 25312269

2014

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 GeneticVariation BEFREE Several neuroblastoma (NB) susceptibility loci have been identified within LINC00340, BARD1, LMO1, DUSP12, HSD17B12, DDX4, IL31RA, HACE1 and LIN28B by genome-wide association (GWA) studies including European American individuals. 23222812

2013

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 Biomarker CTD_human Taken together, these data show that common variants in HACE1 and LIN28B influence neuroblastoma susceptibility and indicate that both genes likely have a role in disease progression. 22941191

2012

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 SusceptibilityMutation ORPHANET The relationship between hygiene and microbial burden in atopic dermatitis risk based on a systematic review. 22911191

2012

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 GeneticVariation BEFREE Taken together, these data show that common variants in HACE1 and LIN28B influence neuroblastoma susceptibility and indicate that both genes likely have a role in disease progression. 22941191

2012

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 GeneticVariation GWASCAT Taken together, these data show that common variants in HACE1 and LIN28B influence neuroblastoma susceptibility and indicate that both genes likely have a role in disease progression. 22941191

2012

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 AlteredExpression BEFREE These findings were fully recapitulated in a mouse model in which LIN28B expression in the sympathetic adrenergic lineage induced development of neuroblastomas marked by low let-7 miRNA levels and high MYCN protein expression. 23042116

2012

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 Biomarker CTD_human These findings were fully recapitulated in a mouse model in which LIN28B expression in the sympathetic adrenergic lineage induced development of neuroblastomas marked by low let-7 miRNA levels and high MYCN protein expression. 23042116

2012

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 GeneticVariation GWASDB Taken together, these data show that common variants in HACE1 and LIN28B influence neuroblastoma susceptibility and indicate that both genes likely have a role in disease progression. 22941191

2012

Entrez Id: 389421
Gene Symbol: LIN28B
LIN28B
CUI: C0027819
Disease: Neuroblastoma
Neuroblastoma
0.900 Biomarker MGD