Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0028754
Disease: Obesity
Obesity
1.000 GeneticVariation BEFREE PPAR-γ gene polymorphism is associated with and increased the risk of psoriasis and its associated obesity in Egyptian patients. 31148857

2020

Entrez Id: 4160
Gene Symbol: MC4R
MC4R
CUI: C0028754
Disease: Obesity
Obesity
1.000 GeneticVariation BEFREE 17 patients with obesity-causing MC4R mutations (BMI: 35.5 ± 7.6) and 35 matched control participants with common obesity (BMI: 34.3 ± 7.1) underwent a DEXA scan for assessment of bone mineral density (BMD), bone mineral apparent density [BMAD = (BMD/√(bone area)], and bone turnover markers (BTMs). 31471646

2020

Entrez Id: 4160
Gene Symbol: MC4R
MC4R
CUI: C0028754
Disease: Obesity
Obesity
1.000 GeneticVariation BEFREE The MC4R p.Ile269Asn mutation accounted for a population attributable risk of 1.28% and 0.68% for childhood and adult obesity, respectively, in the Mexican population. 31841602

2020

Entrez Id: 4160
Gene Symbol: MC4R
MC4R
CUI: C0028754
Disease: Obesity
Obesity
1.000 Biomarker BEFREE The mechanisms underlying altered MC4R trafficking in the context of obesity is still unclear. 31666192

2020

Entrez Id: 4160
Gene Symbol: MC4R
MC4R
CUI: C0028754
Disease: Obesity
Obesity
1.000 Biomarker BEFREE Accordingly, MC4R is a potential drug target to combat obesity. 30642682

2019

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0028754
Disease: Obesity
Obesity
1.000 AlteredExpression BEFREE PPARG mRNA expression decreased 32% (P = 0.044) in adipocytes from individuals with obesity. 31531958

2019

Entrez Id: 4160
Gene Symbol: MC4R
MC4R
CUI: C0028754
Disease: Obesity
Obesity
1.000 Biomarker BEFREE Previous studies have shown that the melanocortin 4 receptor (MC4R) and hepatocyte nuclear factor 4 alpha (HNF4α) genes are associated with obesity and metabolic disorders. 31305461

2019

Entrez Id: 4160
Gene Symbol: MC4R
MC4R
CUI: C0028754
Disease: Obesity
Obesity
1.000 Biomarker BEFREE We believe that our study may help to understand better the impact of MC4R gene on obesity development, and to help to provide personalized prevention/treatment strategies to fight against obesity and its metabolic consequences. 30945034

2019

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0028754
Disease: Obesity
Obesity
1.000 AlteredExpression BEFREE Identification of the factors that regulate PPARγ expression and activity is therefore crucial for combating obesity. 31653699

2019

Entrez Id: 4160
Gene Symbol: MC4R
MC4R
CUI: C0028754
Disease: Obesity
Obesity
1.000 Biomarker BEFREE Mutations leading to a reduced function of the melanocortin-4 receptor (MC4R) exert a major gene effect on extreme obesity. 31035493

2019

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0028754
Disease: Obesity
Obesity
1.000 AlteredExpression BEFREE However, the expression of PPARγ is reduced by obesity and several nutritional factors. 30348686

2019

Entrez Id: 4160
Gene Symbol: MC4R
MC4R
CUI: C0028754
Disease: Obesity
Obesity
1.000 GeneticVariation BEFREE While most MC4R variants caused loss of function, a subset caused gain of function; these variants were associated with significantly lower BMI and lower odds of obesity, type 2 diabetes, and coronary artery disease. 31002796

2019

Entrez Id: 4160
Gene Symbol: MC4R
MC4R
CUI: C0028754
Disease: Obesity
Obesity
1.000 GeneticVariation BEFREE Genetic screening for MC4R gene identifies three novel mutations associated with severe familiar obesity in a cohort of Spanish individuals. 30981838

2019

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0028754
Disease: Obesity
Obesity
1.000 Biomarker BEFREE PD improved obesity in db/db mice by AMPK-associated decrease of adipogenic markers including PPARγ and C/EBPα. 30599906

2019

Entrez Id: 4160
Gene Symbol: MC4R
MC4R
CUI: C0028754
Disease: Obesity
Obesity
1.000 Biomarker BEFREE Insights into the Allosteric Mechanism of Setmelanotide (RM-493) as a Potent and First-in-Class Melanocortin-4 Receptor (MC4R) Agonist To Treat Rare Genetic Disorders of Obesity through an in Silico Approach. 30048591

2019

Entrez Id: 4160
Gene Symbol: MC4R
MC4R
CUI: C0028754
Disease: Obesity
Obesity
1.000 GeneticVariation BEFREE These data provide support for two hypotheses: (i) that the majority of these rare, obesity-associated mutations are likely defective and causative of obesity and (ii) that β-arrestin recruitment is a valuable marker of normal MC4R function. 31529534

2019

Entrez Id: 4160
Gene Symbol: MC4R
MC4R
CUI: C0028754
Disease: Obesity
Obesity
1.000 Biomarker BEFREE Celastrol Reduces Obesity in MC4R Deficiency and Stimulates Sympathetic Nerve Activity Affecting Metabolic and Cardiovascular Functions. 30894367

2019

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0028754
Disease: Obesity
Obesity
1.000 GeneticVariation BEFREE The PPARG rs1801282 (G/C) polymorphism has been associated with OSA in obese Indian subjects, whereas no such association has been reported in Chinese Han subjects. 31044373

2019

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0028754
Disease: Obesity
Obesity
1.000 Biomarker BEFREE An involvement of FABP4 in the pathogenesis of obesity and insulin resistance seems to be mediated via FABP4-dependent peroxisome proliferator-activated receptor γ (PPARγ) inhibition. 30857223

2019

Entrez Id: 4160
Gene Symbol: MC4R
MC4R
CUI: C0028754
Disease: Obesity
Obesity
1.000 GeneticVariation BEFREE This study aims to identify the prevalence of MC4R mutations in children with severe early-onset obesity of African American or Latino ancestry. 30811542

2019

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0028754
Disease: Obesity
Obesity
1.000 Biomarker BEFREE These results conclude that the BGE extract containing several kinds of polymethoxy flavones showed PPARγ ligand-binding capacity in vitro and prevented obesity and insulin resistance independent of adiponectin secretion in mice. 30726580

2019

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0028754
Disease: Obesity
Obesity
1.000 Biomarker BEFREE These tool analysed and found 4 RNAs gene knock out possibilities in PPARγ and their efficiency for further treating obesity. 31152927

2019

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0028754
Disease: Obesity
Obesity
1.000 Biomarker BEFREE Agaricus bisporus-derived β-glucan prevents obesity through PPAR γ downregulation and autophagy induction in zebrafish fed by chicken egg yolk. 30557642

2019

Entrez Id: 5468
Gene Symbol: PPARG
PPARG
CUI: C0028754
Disease: Obesity
Obesity
1.000 AlteredExpression BEFREE VDR and PPARγ mRNA expression was higher in the adipose tissues of GDM women in comparison to that of women with normal glucose tolerance (VDR mRNA: G1 vs. N1: 210.00 [90.58-311.46] vs. 89.34 [63.74-159.92], G2 vs. N2: 298.67 [170.84-451.25] vs. 198.28 [119.46-261.23], PPARγ mRNA: G1 vs. N1: 100.72 [88.61-123.87] vs. 87.52 [66.37-100.04], G2 vs. N2: 117.33 [100.08-149.00] vs. 89.90 [76.95-109.09], P < 0.05), and their expression was the highest in GDM + overweight/obese women. 31651513

2019

Entrez Id: 4160
Gene Symbol: MC4R
MC4R
CUI: C0028754
Disease: Obesity
Obesity
1.000 GeneticVariation BEFREE Melanocortin 4 receptor (MC4R) gene polymorphisms were detected to be associated with different levels of obesity. 31429705

2019