Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 Biomarker BEFREE Recently, LRP5 has also been shown to play a role in chondroblastic subtype of osteosarcoma (OS) and prostate cancer and also in noncancer case such as osteoporosis. 31031810

2019

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 GeneticVariation BEFREE Our study showed a strong association between bone mineral density and polymorphisms in the FDPS gene, and a borderline association with LRP5 and SOST polymorphisms in postmenopausal Romanian women with osteoporosis.No association was found for VKORC1. 31774873

2019

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 GeneticVariation BEFREE The aim of the study was to evaluate the frequency of genotypes and alleles of single nucleotide polymorphism (SNP) rs4988321 and rs312009 of LRP5 in Polish postmenopausal women with osteopenia (n = 109) and osteoporosis (n = 333). 29963786

2019

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 Biomarker BEFREE Disruption of the interaction between LRP5/6 and sclerostin has been recognized as a therapeutic target for osteoporosis. 29486968

2018

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 GeneticVariation BEFREE Mutational analysis uncovers monogenic bone disorders in women with pregnancy-associated osteoporosis: three novel mutations in LRP5, COL1A1, and COL1A2. 29594386

2018

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 GeneticVariation BEFREE Osteoporosis-pseudoglioma syndrome (OPPG) is a rare autosomal recessive syndrome characterized by juvenile-onset osteoporosis and ocular abnormalities due to a low-density lipoprotein receptor-related protein 5 (LRP5) gene mutation. 28866852

2017

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 Biomarker BEFREE The microarray data from the Gene Expression Omnibus database accession number GSE51686, were downloaded and used to identify differentially expressed genes (DEGs) in fracture callus tissue samples obtained from the femora of type I collagen (Col1a1)‑kringle containing transmembrane protein 2 (Krm2) mice and low density lipoprotein receptor‑related protein 5‑/‑ (Lrp5‑/‑) transgenic mice of osteoporosis compared with those in wild‑type (WT) mice. 28487939

2017

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 GeneticVariation BEFREE Polymorphism of LRP5 gene and emphysema severity are associated with osteoporosis in Japanese patients with or at risk for COPD. 25392953

2015

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 GeneticVariation BEFREE Osteoporosis pseudoglioma syndrome (OPPG) is a rare autosomal recessive condition of congenital blindness and severe childhood osteoporosis with skeletal fragility, caused by loss-of-function mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) gene. 25384351

2015

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 GeneticVariation BEFREE In addition to the ocular features, LRP5 mutations can cause osteopenia and osteoporosis. 25323851

2015

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 GeneticVariation BEFREE The A1330V polymorphism of LRP5 is possibly correlated with response to alendronate treatment in Chinese women with osteoporosis, and the TT genotype could possibly predict a weak response to alendronate. 24897288

2014

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 GeneticVariation BEFREE Results identified that carriers of rs3736228 C>T variant in the LRP5 gene were associated with an increased risk of developing osteoporosis and fractures under 4 genetic models but not under the dominant model (OR = 1.19, 95% CI = 0.97~1.46, and P = 0.103). 25580429

2014

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 GeneticVariation BEFREE Because her neonatal unilateral blindness and OP were suggestive of loss-of-function mutation(s) in the gene that encodes LDL receptor-related protein 5 (LRP5), LRP5 exon and splice site sequencing was also performed. 24014470

2014

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 GeneticVariation BEFREE Her half-brother, treated with cabergoline for a microprolactinoma, also had osteoporosis of the lumbar spine on dual-energy x-ray absorptiometry and carried the same LRP5 mutation. 24423337

2014

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 Therapeutic RGD Effects of pulsed electromagnetic fields on bone mass and Wnt/β-catenin signaling pathway in ovariectomized rats. 22704852

2012

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 AlteredExpression BEFREE In comparison to age-matched controls we detected profound changes in the transcriptome in hMSC-OP, e.g. enhanced mRNA expression of known osteoporosis-associated genes (LRP5, RUNX2, COL1A1) and of genes involved in osteoclastogenesis (CSF1, PTH1R), but most notably of genes coding for inhibitors of WNT and BMP signaling, such as Sclerostin and MAB21L2. 23028809

2012

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 Therapeutic RGD Zuogui Pill can prevent and treat glucocorticoid-induced osteoporosis in rats by up-regulating the expression of the key signal molecules Wnt1, LRP-5 and beta-catenin in Wnt signal transduction pathway. 21977807

2011

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 GeneticVariation BEFREE In this study, we found common polymorphisms of LRP5 associated with osteoporotic fractures, and polymorphisms of the LRP6 gene associated with BMD, thus suggesting them as likely candidates to contribute to the explaination of the hereditary influence on osteoporosis. 20926594

2011

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 GeneticVariation BEFREE Rheumatologists must be aware of LRP5 gene that in addition to being a major gene in the mendelian disease that is OPPG syndrome seems to be involved in osteoporosis in the general population through some of its polymorphisms. 20096619

2010

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 Biomarker BEFREE LRP5 was recently confirmed as an important susceptibility gene for osteoporosis. 20101398

2010

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 GeneticVariation BEFREE Evidence suggested a role for genetic variation in IL6 and LRP5 in conferring risk for osteoporosis in Caucasian women, with the latter manifest only in smokers. 19506792

2010

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 GeneticVariation BEFREE Previous studies have shown that polymorphisms of the LRP5 gene are associated with bone mineral density (BMD), but the relationship between LRP5 polymorphisms and response to bisphosphonate treatment in osteoporosis has not been studied. 19148563

2009

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 GeneticVariation BEFREE These data suggest that the A1330V variation in the LRP5 gene may affect the pathogenesis of osteoporosis. 19571442

2009

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 GeneticVariation BEFREE A haplotype-based analysis of the LRP5 gene in relation to osteoporosis phenotypes in Spanish postmenopausal women. 18684085

2008

Entrez Id: 4041
Gene Symbol: LRP5
LRP5
CUI: C0029456
Disease: Osteoporosis
Osteoporosis
0.900 GeneticVariation BEFREE A non-synonymous SNP in the LRP5 gene was associated with decreased bone mineral density (rs3736228, p=6.3x10(-12) for lumbar spine and p=1.9x10(-4) for femoral neck) and an increased risk of both osteoporotic fractures (odds ratio [OR] 1.3, 95% CI 1.09-1.52, p=0.002) and osteoporosis (OR 1.3, 1.08-1.63, p=0.008). 18455228

2008