Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE Aberrant Promoter Hypermethylation of RASSF1a and BRCA1 in Circulating Cell-Free Tumor DNA Serves as a Biomarker of Ovarian Carcinoma. 31653147

2019

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Alteration of expression of the tumor suppressor gene BRCA-1 has been widely studied in breast and ovarian carcinoma. 30446260

2019

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE BRCA1/2 pathogenic (P) and likely pathogenic (LP) germline variants are frequent among patients with ovarian carcinoma. 30606148

2019

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Risk-reducing salpingo-oophorectomy (RRSO) is recommended for BRCA1/2 mutation carriers because of their increased risk of ovarian carcinoma. 29315498

2018

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Potent immunogenicity in BRCA1-mutated patients with high-grade serous ovarian carcinoma. 29855141

2018

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE Routine germline BRCA1 and BRCA2 testing in patients with ovarian carcinoma: analysis of the Scottish real-life experience. 29460478

2018

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Clinical characteristics and outcomes of patients with BRCA1 or RAD51C methylated versus mutated ovarian carcinoma. 29233532

2018

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma. 30266954

2018

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high-grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: Integrated analysis of data from Study 10 and ARIEL2. 28882436

2017

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE With the recent introduction of Poly(ADP-ribose) polymerase inhibitors, a promising novel therapy has become available for ovarian carcinoma (OC) patients with inactivating BRCA1 or BRCA2 mutations in their tumor. 27767231

2017

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE A high proportion of young women with invasive OC have mutations in BRCA1, and a smaller fraction have mutations in other known OC genes. 26718727

2016

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Eligible patients are premenopausal BRCA1/2 mutation carriers after completing childbearing without (a history of) ovarian carcinoma. 26286255

2015

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 PosttranslationalModification BEFREE BRCA1 promoter hypermethylation and protein expression in ovarian carcinoma--an Indian study. 24385383

2014

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 AlteredExpression BEFREE Reduced BRCA1 gene expression is common in the sporadic form of ovarian carcinoma. 23339184

2013

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE This study shows that BRCA1 IHC is well correlated with molecular events in ovarian carcinoma. 23232854

2013

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE The germline BRCA1 mutation rate in USC subjects of 2% is higher than expected in a nonfounder population, suggesting that USC is associated with hereditary breast and ovarian carcinoma in a small proportion of cases. 22811390

2013

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Morphologic patterns associated with BRCA1 and BRCA2 genotype in ovarian carcinoma. 22193042

2012

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 AlteredExpression BEFREE We found that high-grade serous ovarian carcinoma had significantly higher MIR182 (P=0.0003) and HMGA2 (P=0.04) expression, and significantly lower BRCA1 (P<0.0001) and FOXO3 (P<0.001) expression than normal controls. 22790015

2012

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE This study suggests that BRCA1 protein is a prognostic marker in sporadic OC patients with minimal RD. 21368065

2011

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE Here, we show that the p53-related gene p73, encoding a proapoptotic protein that is linked to chemosensitivity in many settings, is upregulated through a novel epigenetic mechanism in both human and murine models of BRCA1-associated ovarian carcinoma. 20807817

2010

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE Four carriers of pathogenic mutations in both BRCA1 and BRCA2 were identified among women who underwent genetic counseling for hereditary susceptibility to breast and ovarian carcinoma at three different Italian institutions. 20373018

2010

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 AlteredExpression BEFREE Low BRCA1 expression in primary sporadic ovarian carcinoma is associated with prolonged survival. 19602291

2009

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 Biomarker BEFREE Intraepithelial T cells and prognosis in ovarian carcinoma: novel associations with stage, tumor type, and BRCA1 loss. 19060844

2009

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE We propagated a novel BRCA1-null human ovarian cancer cell line UWB1.289 from a tumor of papillary serous histology, the most common form of ovarian carcinoma. 17259345

2007

Entrez Id: 672
Gene Symbol: BRCA1
BRCA1
CUI: C0029925
Disease: Ovarian Carcinoma
Ovarian Carcinoma
0.500 GeneticVariation BEFREE The identification of germ-line mutations in 2 genes (BRCA1 and BRCA2) responsible for the majority of hereditary ovarian cancers has led an increasing number of women carriers of these mutations to undergo prophylactic oophorectomy (PO) to reduce their risk of subsequent ovarian carcinoma. 17001151

2006