Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 GeneticVariation BEFREE This can have implications for screening and for the diagnosis of pancreatic neoplasms in carriers of germline CDKN2A mutations. 31261289

2019
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 Biomarker CTD_human Common variation at 2p13.3, 3q29, 7p13 and 17q25.1 associated with susceptibility to pancreatic cancer. 26098869

2015
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 GeneticVariation BEFREE In this study, three patients who developed both melanoma and intraepithelial neoplasia of the pancreas were tested for CDKN2A mutations and deletions, and investigated for rare germline copy number variations (CNVs). 24984283

2014
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 GeneticVariation BEFREE In LSL-Kras(G12D)/Pdx-1-Cre/Ink4a/Arf(lox/+) mice, calorie restriction versus overweight- or obesity-inducing diet regimens decreased serum IGF-I, tumoral Akt/mTOR signaling, pancreatic desmoplasia, and progression to pancreatic ductal adenocarcinoma (PDAC), and increased pancreatic tumor-free survival. 23980075

2013
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 GeneticVariation BEFREE The INK4a-ARF locus plays a central role in the development of pancreatic tumors as evidenced by the fact that up to 98% of pancreatic tumor specimens harbored genetic alterations at the INK4a-ARF locus. 23727582

2013
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 GeneticVariation LHGDN Low prevalence of CDKN2A/ARF mutations among early-onset cancers of breast, pancreas and malignant melanoma in Poland. 18714178

2008
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 Biomarker LHGDN Genetic testing in familial melanoma: uptake and implications. 18613292

2008
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 GeneticVariation LHGDN Detecting low-abundance p16 and p53 mutations in pancreatic juice using a novel assay: heteroduplex analysis of limiting dilution PCRs. 17106238

2006
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 Biomarker LHGDN Alterations of tumor suppressor gene p16INK4a in pancreatic ductal carcinoma. 15985168

2005
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 AlteredExpression LHGDN Restoration of protein synthesis in pancreatic cancer cells by trans-splicing ribozymes. 15336553

2004
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 AlteredExpression BEFREE The fate of pancreatic tumor cell lines following p16 overexpression depends on the modulation of CDK2 activity. 15309028

2004
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 Biomarker LHGDN INK4/ARF germline alterations in pancreatic cancer patients. 14679123

2004
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 GeneticVariation LHGDN Familial melanoma, pancreatic cancer and germline CDKN2A mutations. 15146471

2004
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 Biomarker BEFREE Delivery of ALSV-A-based RCAS vectors encoding either mouse polyoma virus middle T antigen (PyMT) or c-Myc to elastase-tv-a transgenic, Ink4a/Arf null mice induced the formation of pancreatic tumors. 14681205

2003
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 Biomarker BEFREE The p16INK4a-/retinoblastoma tumour-suppressive pathway has been shown to be involved in the development of near to all pancreatic neoplasms. p14ARF is another tumour suppressor located in the immediate neighbourhood of p16INK4a. 12610506

2003
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 GeneticVariation LHGDN High prevalence of the G101W germline mutation in the CDKN2A (P16(ink4a)) gene in 62 Italian malignant melanoma families. 11807902

2002
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 Biomarker BEFREE Experiments on subcutaneous pancreatic xenografts demonstrated the effectiveness of p16 in the inhibition of pancreatic tumor growth in vivo. 11687897

2001
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 Biomarker CTD_human Novel germline p16(INK4) allele (Asp145Cys) in a family with multiple pancreatic carcinomas. Mutations in brief no. 148. Online. 10627132

1998
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 AlteredExpression BEFREE To directly investigate genetic alterations and expression of p16/MTS1 and p15/MTS2, this study surveyed pancreatic tumors. 8613012

1996
Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 GeneticVariation UNIPROT

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 Biomarker HPO

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 GenomicAlterations CGI

Entrez Id: 1029
Gene Symbol: CDKN2A
CDKN2A
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm 		0.800 CausalMutation CGI