Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3593
Gene Symbol: IL12B
IL12B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.400 Biomarker BEFREE After getting evidence of IL12p40 encoded by IL12B as a possible therapeutic target by showing similarities of the genetic background between TAK and ulcerative colitis, we performed a pilot clinical study of ustekinumab, a monoclonal antibody against IL12p40 for patients with refractory TAK and obtained good response. 29651889

2018

Entrez Id: 3593
Gene Symbol: IL12B
IL12B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.400 GeneticVariation BEFREE IL12B rs6871626 did not show an association with IBD-TA compared with that with TA without IBD. 28449344

2017

Entrez Id: 3593
Gene Symbol: IL12B
IL12B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.400 GeneticVariation BEFREE A novel susceptibility locus in the IL12B region is associated with the pathophysiology of Takayasu arteritis through IL-12p40 and IL-12p70 production. 28874185

2017

Entrez Id: 3593
Gene Symbol: IL12B
IL12B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.400 GeneticVariation BEFREE Outside the HLA region, only one polymorphism located nearby the IL12B gene surpassed the study-wide significance threshold in the meta-analysis of the discovery datasets (rs755374, P = 7.54E-07; OR<sub>GCA</sub> = 1.19, OR<sub>TAK</sub> = 1.50). 28277489

2017

Entrez Id: 3593
Gene Symbol: IL12B
IL12B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.400 GeneticVariation BEFREE We demonstrated a allele association between the four SNPs of IL12B and TA (rs6871626: OR 1.52, 95% CI 1.26-1.83; rs4921492: OR 1.46, 95% CI 1.21-1.75; rs60689680: OR 1.41, 95% CI 1.17-1.69; rs4921493: OR 1.45, 95% CI 1.21-1.75, all P <sub>c</sub>  < 10<sup>- 3</sup> ). 28160070

2017

Entrez Id: 3593
Gene Symbol: IL12B
IL12B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.400 Biomarker BEFREE In particular, the IL12B region seems to have a central role in TAK onset and its progression. 26178430

2016

Entrez Id: 3593
Gene Symbol: IL12B
IL12B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.400 GeneticVariation BEFREE Recently, our group reported that SNP rs6871626 in the IL12B region had significant association with disease susceptibility to TAK. 25783557

2016

Entrez Id: 3593
Gene Symbol: IL12B
IL12B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.400 GeneticVariation BEFREE Four single nucleotide polymorphisms (SNPs) those locate in the IL12B region (rs56167332), the MLX region (rs665268), the FCGR2A/FCGR3A locus (rs10919543), and the HLA-B/MICA locus (rs12524487), associated with TA in different population, were genotyped in 123 Chinese TA patients and 147 healthy controls from January 2013 to August 2014. 26996483

2016

Entrez Id: 3593
Gene Symbol: IL12B
IL12B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.400 Biomarker BEFREE Since TAK and UC share HLA-B*52:01 and IL12B as genetic determinants, and since there are case reports of the co-occurrence of these diseases, we hypothesized that UC is a common complication of TAK. 25931203

2015

Entrez Id: 3593
Gene Symbol: IL12B
IL12B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.400 SusceptibilityMutation ORPHANET The prevalence and characteristics of microalbuminuria in the general population: a cross-sectional study. 23830507

2013

Entrez Id: 3593
Gene Symbol: IL12B
IL12B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.400 Biomarker BEFREE Our findings indicate that IL12B plays a fundamental role on the pathophysiology of TAK in combination with HLA-B(∗)52:01 and that common autoimmune mechanisms underlie the pathology of TAK and other autoimmune disorders such as psoriasis and inflammatory bowel diseases in which IL12B is involved as a genetic predisposing factor. 23830516

2013

Entrez Id: 3593
Gene Symbol: IL12B
IL12B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.400 SusceptibilityMutation ORPHANET Our findings indicate that IL12B plays a fundamental role on the pathophysiology of TAK in combination with HLA-B(∗)52:01 and that common autoimmune mechanisms underlie the pathology of TAK and other autoimmune disorders such as psoriasis and inflammatory bowel diseases in which IL12B is involved as a genetic predisposing factor. 23830516

2013

Entrez Id: 3593
Gene Symbol: IL12B
IL12B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.400 GeneticVariation BEFREE We also established the genetic association between IL12B and Takayasu arteritis (rs56167332, OR = 1.54, p = 2.18 × 10(-8)). 23830517

2013

Entrez Id: 3593
Gene Symbol: IL12B
IL12B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.400 GeneticVariation BEFREE The frequencies of IL12B 1188 C allele (p = 0.03, OR = 1.7) and CC genotype (p = 0.007, OR = 3.7) were both higher in TA patients than in control subjects. 17002904

2006