Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 GeneticVariation BEFREE HLA-B*52 is an established susceptibility locus to TAK. 30498034

2018

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 GeneticVariation GWASCAT Genetic determinants and an epistasis of LILRA3 and HLA-B*52 in Takayasu arteritis. 30498034

2018

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 GeneticVariation BEFREE Association between genetic variants in the human leukocyte antigen-B/MICA and Takayasu arteritis in Chinese Han population. 28261975

2018

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 GeneticVariation BEFREE The genetic susceptibility with HLA-B*52, as well as additional classical alleles and loci, implicate both HLA class I and class II involvement in TAK. 28756073

2017

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 Biomarker BEFREE In the genetic comparison of HLA class I between TA patients with IBD and those without IBD, HLA-B*52:01 and C*12:02 were more frequent in the IBD-TA group (P = 0.001 and P = 0.009, respectively). 28449344

2017

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 Biomarker BEFREE HLA-B*52:01-C*12:02, which is found in approximately 20% of all Japanese persons, is well known to be associated with ulcerative colitis and Takayasu arteritis. 28968792

2017

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 GeneticVariation BEFREE This meta-analysis demonstrated that the HLA-B*52 allele and TNF-α-308 A/G polymorphism may contribute to TA susceptibility. 27815653

2017

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 GeneticVariation BEFREE HLA-B*67:01 is a novel susceptibility HLA-B allele to TAK confirmed in the Japanese population. 26178430

2016

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 Biomarker BEFREE Since TAK and UC share HLA-B*52:01 and IL12B as genetic determinants, and since there are case reports of the co-occurrence of these diseases, we hypothesized that UC is a common complication of TAK. 25931203

2015

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 GeneticVariation GWASCAT Identification of Susceptibility Loci in IL6, RPS9/LILRB3, and an Intergenic Locus on Chromosome 21q22 in Takayasu Arteritis in a Genome-Wide Association Study. 25604533

2015

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 Biomarker BEFREE HLA-B*52:01 and *67:01 are susceptibility alleles to TAK, and the 171st and 67th amino acid residues of HLA-B protein are suggested important for TAK susceptibility. 24548718

2014

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 SusceptibilityMutation ORPHANET The prevalence and characteristics of microalbuminuria in the general population: a cross-sectional study. 23830507

2013

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 Biomarker BEFREE HLA-B 67:01 is associated with TAK independently from HLA-B 52:01. 23873822

2013

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 SusceptibilityMutation ORPHANET Our findings indicate that IL12B plays a fundamental role on the pathophysiology of TAK in combination with HLA-B(∗)52:01 and that common autoimmune mechanisms underlie the pathology of TAK and other autoimmune disorders such as psoriasis and inflammatory bowel diseases in which IL12B is involved as a genetic predisposing factor. 23830516

2013

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 Biomarker BEFREE The etiology of Takayasu arteritis remains poorly understood, but genetic contribution to the disease pathogenesis is supported by the genetic association with HLA-B*52. 23830517

2013

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 Biomarker BEFREE Our findings indicate that IL12B plays a fundamental role on the pathophysiology of TAK in combination with HLA-B(∗)52:01 and that common autoimmune mechanisms underlie the pathology of TAK and other autoimmune disorders such as psoriasis and inflammatory bowel diseases in which IL12B is involved as a genetic predisposing factor. 23830516

2013

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 Biomarker BEFREE However, they are associated with two different vasculitides (HLA-B*51 in Behçet's disease and HLA-B*52 in Takayasu's arteritis (TAK)) and with major clinical and immunological differences. 22309845

2012

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 GeneticVariation BEFREE This preliminary study suggests a difference in the distribution of the residues 63 and 67 of the HLA-B alleles in patients with TA and TB. 18646257

2008

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 Biomarker LHGDN This preliminary study suggests a difference in the distribution of the residues 63 and 67 of the HLA-B alleles in patients with TA and TB. 18646257

2008

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 GeneticVariation BEFREE Therefore, the aim of the present study was to analyze the distribution of HLA-B alleles in TA (n = 40) and Tb (n = 34) patients and healthy controls (72 exposed and 99 nonexposed). 17462513

2007

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 GeneticVariation LHGDN In spite of the loose clinical relationship between TA and Tb, we did not detected any genetic relationship between them when the HLA-B alleles were analyzed in these groups of patients. 17462513

2007

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 Biomarker BEFREE Studies both in Mexican and Asian populations suggest that residues at positions 63 (glutamic acid) and 67 (serine) of the HLA-B molecule could be the genetic markers for TA. 15585327

2005

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 Biomarker LHGDN In the present work, we analyzed the sequence of HLA-B alleles in 26 TA patients and 62 healthy controls. 15585327

2005

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 GeneticVariation BEFREE We studied HLA-B alleles of 12 Mexican patients with TA using PCR-SSP and sequencing. 10980349

2000

Entrez Id: 3106
Gene Symbol: HLA-B
HLA-B
CUI: C0039263
Disease: Takayasu Arteritis
Takayasu Arteritis
0.500 GeneticVariation BEFREE Combined analyses of polymorphisms in the HLA-B and MICA genes with those in the microsatellites suggest that there are two different disease-susceptible loci for Takayasu's arteritis; one is mapped near the C1-2-A locus and the other is more closely linked to the HLA-B gene than to the MICA gene, because there are at least two different disease-associated HLA-B haplotypes, HLA-B*52 and -B*39.2 haplotypes, in which the disease-associated C1-2-A allele is shared in common. 10980346

2000