Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 114609
Gene Symbol: TIRAP
TIRAP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.380 GeneticVariation BEFREE The aim of this study was to investigate the relationship of <i>TLR1, TLR6, MYD88</i> and <i>TIRAP</i> polymorphisms with susceptibility to latent tuberculosis infection (LTBI) and tuberculosis (TB). 30963003

2019

Entrez Id: 114609
Gene Symbol: TIRAP
TIRAP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.380 Biomarker BEFREE To test common and rare TLR variants involved in susceptibility or resistance to infection with Mycobacterium tuberculosis we screened the exons of the genes encoding TLR 1, 2, 4, and the adaptor molecule TIRAP in more than 4500 tuberculosis (TB) cases and controls from Ghana. 27214039

2016

Entrez Id: 114609
Gene Symbol: TIRAP
TIRAP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.380 GeneticVariation BEFREE Humans that are heterozygous for the common S180L polymorphism in the Toll-like receptor (TLR) adaptor Mal (encoded by TIRAP) are protected from a number of infectious diseases, including tuberculosis (TB), whereas those homozygous for the allele are at increased risk. 26885859

2016

Entrez Id: 114609
Gene Symbol: TIRAP
TIRAP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.380 GeneticVariation BEFREE Coinheritance of these polymorphisms with previously identified risk alleles in Toll-like receptor 2 and TIRAP was associated with an additive risk of tuberculosis susceptibility. 22223854

2012

Entrez Id: 114609
Gene Symbol: TIRAP
TIRAP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.380 GeneticVariation BEFREE We investigated all the single-nucleotide polymorphisms (SNPs) within the TIRAP exon 5 in a case-control study of 212 patients with tuberculosis and 215 controls in a Chinese population. 21218381

2011

Entrez Id: 114609
Gene Symbol: TIRAP
TIRAP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.380 GeneticVariation BEFREE Polymorphisms in TIRAP do not appear to be involved in childhood TB susceptibility in South Africa, but may play a role in determining occurrence of TBM. 19693265

2009

Entrez Id: 114609
Gene Symbol: TIRAP
TIRAP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.380 GeneticVariation BEFREE These results support the influence of TIRAP (MAL) S180L polymorphism on TB and indicate that TB and SLE might share a common immunogenetic pathway in the innate immune response. 18417424

2008

Entrez Id: 114609
Gene Symbol: TIRAP
TIRAP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.380 GeneticVariation LHGDN Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations. 18305471

2008

Entrez Id: 114609
Gene Symbol: TIRAP
TIRAP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.380 GeneticVariation LHGDN These results support the influence of TIRAP (MAL) S180L polymorphism on TB and indicate that TB and SLE might share a common immunogenetic pathway in the innate immune response. 18417424

2008

Entrez Id: 114609
Gene Symbol: TIRAP
TIRAP
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.380 Biomarker CTD_human A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis. 17322885

2007