Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE Elucidation of the immune mechanisms associated with tuberculosis (TB) development may help to control <i>M. tuberculosis</i> spread<i>.</i>OBJECTIVE: To investigate the role of TLR2, TLR4 and TLR9 in hindered in vitro microbicidal activity and increase T<sub>reg</sub> number during LTBI. 30808454

2019

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 AlteredExpression BEFREE Using a trend test, we found that expression of Toll-like receptor 2 was greater from absence of infection to latent infection and from latent infection to active tuberculosis. 29104936

2019

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE PPE65 of M. tuberculosis regulate pro-inflammatory signalling through LRR domains of Toll like receptor-2. 30471865

2019

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE Of note, network analysis comparing TB-associated host genes identified in the current HIV-negative TB cohort to TB-associated genes identified in our previously published Ethiopian HIV-positive TB cohort, revealed an over-representation of pattern recognition receptors including TLR2 and TLR4 in the HIV-positive cohort which was not seen in the HIV-negative cohort. 31821366

2019

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE Toll-like Receptor 2 Prevents Neutrophil-Driven Immunopathology during Infection with Mycobacterium tuberculosis by Curtailing CXCL5 Production. 30559223

2019

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE Macrophages were stimulated with TLR-2 agonist M. tuberculosis lipoprotein (LpqH), live and gamma-irradiated M. tuberculosis. 31039752

2019

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation BEFREE this meta-analysis suggested the following: (1) TLR2 Arg753Gln polymorphism is significantly associated with high TB risk. 30733958

2019

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE To investigate the role of TLR2 during mycobacterial infection, we analyzed the response of tlr2 zebrafish mutant larvae to infection with Mycobacterium marinum (Mm), a close relative to Mtb, as a model for tuberculosis. 31747871

2019

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE CD157 Confers Host Resistance to Mycobacterium tuberculosis via TLR2-CD157-PKCzeta-Induced Reactive Oxygen Species Production. 31455656

2019

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 AlteredExpression BEFREE Information on expression of TLR-2, myeloid differentiation factor (MyD88), IL-1R- associated kinase-4 (IRAK4) and nuclear factor kappa B (NF-kB) in HIV+LTBI+ and HIV+ patients with active TB disease is limited. 29778672

2018

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 AlteredExpression BEFREE CD1c<sup>+</sup>CD11b<sup>+</sup> DC subset from tuberculous pleural effusions expressed higher levels of TLR2, TLR4, CD172a, CD206 and FcεRⅠ, but lower levels of CD80, CD83 and CD86 compared with CD1c<sup>+</sup>CD11b<sup>-</sup> DC subset. 30514502

2018

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation BEFREE Evaluation of TLR2, TLR4, and TOLLIP polymorphisms for their role in tuberculosis susceptibility. 29924447

2018

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE Diminished TLR2-TLR9 mediated CD4+ T cell responses are associated with increased inflammation in intraocular tuberculosis. 30218032

2018

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 AlteredExpression BEFREE Radioprotective 105 kDa (RP105, CD180) is a member of the Toll-like receptor (TLR) family that interacts with TLR2 and facilitates recognition of mature lipoproteins expressed by Mycobacterium tuberculosis and Mycobacterium bovis BCG. 29345364

2018

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation BEFREE Importance of common TLR2 genetic variants on clinical phenotypes and risk in tuberculosis disease in a Western Chinese population. 29486365

2018

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE Mycobacterium tuberculosis Lipoprotein and Lipoglycan Binding to Toll-Like Receptor 2 Correlates with Agonist Activity and Functional Outcomes. 30037791

2018

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 AlteredExpression BEFREE Neutrophil CD64, TLR2 and TLR4 expression increases but phagocytic potential decreases during tuberculosis. 30029898

2018

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation BEFREE The R753Q TLR2 polymorphism has been associated with increased incidence of tuberculosis and infections with non-tuberculous mycobacteria in human populations, but the mechanisms by which this polymorphism affects TLR2 signaling are unclear. 28442574

2017

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE Protein O-mannosylation deficiency increases LprG-associated lipoarabinomannan release by Mycobacterium tuberculosis and enhances the TLR2-associated inflammatory response. 28801649

2017

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 AlteredExpression BEFREE Furthermore, the levels of TLR2, TLR4 and IFN-γ mRNA expression were marked increased in the tuberculous PE when compared with the correspondent serum. 28494727

2017

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE In the present study, we investigated direct immune responses of PMCs against two mycobacterial strains, M. bovis vaccine strain Bacille Calmette-Guérin (BCG) and M. tuberculosis virulent strain H37Rv, and the role of TLR2 in such responses. 28249177

2017

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 GeneticVariation BEFREE GA753 TLR2 polymorphism may play a role in the susceptibility to pulmonary and peritoneal TB infection. 28332241

2017

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE Collectively, these findings demonstrated that miR-23a-5p modulated the innate host defense by promoting mycobacteria survival and inhibiting the activation of autophagy against M.tb. through TLR2/MyD88/NF-κB pathway by targeting TLR2, which may provide a promising therapeutic target for tuberculosis. 28327409

2017

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE This led us to decipher the relative contribution of TLR2 on nonhematopoietic and hematopoietic cells in resistance against chronic M. tuberculosis infection in mice infected with M. tuberculosis Erdman. 27920273

2017

Entrez Id: 7097
Gene Symbol: TLR2
TLR2
CUI: C0041296
Disease: Tuberculosis
Tuberculosis
0.100 Biomarker BEFREE Cryopreserved peripheral blood mononuclear cells from time-points before TB recurrence were stimulated with ligands for Toll-like receptors (TLR) including TLR-2, TLR-4, and TLR-7/8. 27654812

2017