Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 Biomarker BEFREE The pooled sensitivity, specificity, PLR, and NLR of IP-10 for PTB detection were 86, 88%, 7.00, and 0.16, respectively. 31666025

2019

Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 AlteredExpression BEFREE IP-10 levels in plasma, DPS and DBS samples collected before, during (2 months) and after TB treatment of 36 EPTB patients (6 culture and/or Xpert MTB/RIF positive and 30 clinically diagnosed) and 8 pulmonary tuberculosis (PTB) patients, were quantified by an enzyme-linked immunosorbent assay. 30846768

2019

Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 AlteredExpression BEFREE Finally, we showed that the serum levels of IL-1α, IL-6, C-reactive protein (CRP), IL-23, and IP-10 were significantly reduced in <i>M. tuberculosis</i>/HIV-coinfected individuals with PTB compared to those in HIV-negative individuals with PTB (<i>P < </i>0.05), suggesting that HIV infection significantly suppresses <i>M. tuberculosis</i>-induced systemic proinflammatory cytokine responses. 30541853

2019

Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 Biomarker BEFREE Moreover, the sensitivity and specificity of IP-10 for differentiating of PTB and LTBI following stimulation with recombinant PE35 and PPE68 were 770 pg/ml (sensitivity: 63%; specificity: 62%) and 502 pg/ml (sensitivity: 80%; specificity: 52%), respectively. 31564016

2019

Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 Biomarker BEFREE Taken together, combination of IP-10 and RANTES could be potentially used as diagnostic and monitoring biomarker in PTB management. 30029914

2018

Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 GeneticVariation BEFREE Regulatory role of CCL5 (rs2280789) and CXCL10 (rs56061981) gene polymorphisms on intracellular CCL5 and CXCL10 expression in pulmonary tuberculosis. 28336310

2018

Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 Biomarker BEFREE Urine IP-10 as a biomarker of therapeutic response in patients with active pulmonary tuberculosis. 29843631

2018

Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 Biomarker BEFREE The combination of IFN-γ, TNF-α, and IL-2R, and the combination of TNF-α, IL-2R, CXCL9, and CXCL10 showed the best performance for detecting active PTB (both 100% positivity) and LTBI (86.36% and 81.82% positivity, respectively). 25528189

2015

Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 Biomarker BEFREE We found that the presence of the "C" allele increases the transcriptional activity of the TLR9, which in turn induces high levels of Interferon gamma-induced protein 10 (IP-10), a biomarker for PTB. 25248338

2014

Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 Biomarker BEFREE Finally, clinical analysis showed that IL-27 was detected in the bronchoalveolar lavage of patients with asthma, chronic obstructive pulmonary disease (COPD), and pulmonary tuberculosis (PTB), and increased IL-27 concentrations were correlated with increased CXCL10 concentrations in patients with COPD and PTB. 23333920

2013

Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 Biomarker BEFREE IL-27 is elevated in patients with COPD and patients with pulmonary TB and induces human bronchial epithelial cells to produce CXCL10. 21778255

2012

Entrez Id: 3627
Gene Symbol: CXCL10
CXCL10
CUI: C0041327
Disease: Tuberculosis, Pulmonary
Tuberculosis, Pulmonary
0.100 AlteredExpression BEFREE Peripheral blood mononuclear cells obtained from 21 pulmonary tuberculosis (PTB) patients and 24 healthy controls (HCs) were cultured for 48 h with culture filtrate antigen (CFA) of Mycobacterium tuberculosis with or without vitamin D(3) at a concentration 1 × 10(-7)M. The relative mRNA expression of monocyte chemoattractant protein-1 (MCP-1, CCL2), macrophage inflammatory protein-1α (MIP-1α, CCL3), macrophage inflammatory protein-1β (MIP-1β, CCL4), and regulated upon-activation, normal T cell-expressed and secreted (RANTES, CCL5) and IFN-γ inducible protein-10 (IP-10, CXCL10) chemokines were estimated from 48 h old macrophages using real-time polymerase chain reaction (RT-PCR). 22800603

2012