Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 81037
Gene Symbol: CLPTM1L
CLPTM1L
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.460 GeneticVariation GWASCAT Identification of risk loci and a polygenic risk score for lung cancer: a large-scale prospective cohort study in Chinese populations. 31326317

2019

Entrez Id: 81037
Gene Symbol: CLPTM1L
CLPTM1L
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.460 GeneticVariation GWASCAT Lung Cancer Risk in Never-Smokers of European Descent is Associated With Genetic Variation in the 5p15.33 TERT-CLPTM1Ll Region. 31009812

2019

Entrez Id: 81037
Gene Symbol: CLPTM1L
CLPTM1L
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.460 GeneticVariation BEFREE The long TL genetic score was significantly associated with increased risk of lung adenocarcinoma (P = 6.3 × 10(-15)), even after exclusion of a SNP residing in a known lung cancer susceptibility region (TERT-CLPTM1L) P = 6.6 × 10(-6)). 26138067

2015

Entrez Id: 81037
Gene Symbol: CLPTM1L
CLPTM1L
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.460 GeneticVariation BEFREE Gene variations rs2736100 and rs2853676 in TERT and rs401681 and rs31489 in CLPTM1L had significant direct associations on lung adenocarcinoma without indirect effects through nicotine dependence. 25233467

2014

Entrez Id: 81037
Gene Symbol: CLPTM1L
CLPTM1L
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.460 GeneticVariation BEFREE A recent genome-wide association study of lung cancer among never-smoking females in Asia demonstrated that the rs2736100 polymorphism in the TERT-CLPTM1L locus on chromosome 5p15.33 was strongly and significantly associated with risk of adenocarcinoma of the lung. 23555636

2013

Entrez Id: 81037
Gene Symbol: CLPTM1L
CLPTM1L
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.460 AlteredExpression BEFREE Here we find CLPTM1L expression to be increased in lung adenocarcinomas compared to matched normal lung tissues and in lung tumor cell lines by mechanisms not exclusive to copy number gain. 22675468

2012

Entrez Id: 81037
Gene Symbol: CLPTM1L
CLPTM1L
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.460 GeneticVariation BEFREE Multiple variants of TERT and CLPTM1L constitute risk factors for lung adenocarcinoma. 22370939

2012

Entrez Id: 81037
Gene Symbol: CLPTM1L
CLPTM1L
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.460 AlteredExpression BEFREE Here using immunohistochemistry, we found that CLPTM1L expression was markedly increased in lung cancer tissues relative to normal tissues, especially in lung adenocarcinoma. 23300716

2012

Entrez Id: 81037
Gene Symbol: CLPTM1L
CLPTM1L
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.460 Biomarker CTD_human Here we find CLPTM1L expression to be increased in lung adenocarcinomas compared to matched normal lung tissues and in lung tumor cell lines by mechanisms not exclusive to copy number gain. 22675468

2012

Entrez Id: 81037
Gene Symbol: CLPTM1L
CLPTM1L
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.460 GeneticVariation GWASCAT A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. 19836008

2009

Entrez Id: 81037
Gene Symbol: CLPTM1L
CLPTM1L
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder)
0.460 GeneticVariation GWASDB A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma. 19836008

2009