Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 Biomarker BEFREE Within this scope, we discuss the current knowledge concerning the structure and function of aggrecan in intervertebral disc degeneration. 29992840

2019

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 Biomarker BEFREE The content of lactic acid gradually increased after annular lesion, associated with the damage of AF structural and the decrease of Col -II and aggrecan in NP tissue, which leading to the disc degeneration. 31747924

2019

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 Biomarker BEFREE The in vivo experiments showed that the HIF-2α controlled the catabolic factors MMP-13 and ADAMTS-4 that regulated the collagen II and aggrecan metabolism in disc degeneration. 31251999

2019

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 Biomarker BEFREE Polymorphisms in several structural and inflammatory genes like collagens, aggrecan, matrix metalloproteinases are associated with the risk of disc degeneration. 30288688

2018

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 AlteredExpression BEFREE An in vitro model of disc degeneration using human nucleus pulposus cells (hNPCs) and ex vivo culture of mouse intervertebral discs organs under the actions of inflammatory cytokines were used, and the expression of Col II and aggrecan in hNPCs were detected by semi-quantitative western blot analysis, and the mRNA expression of the genes than encode Col II and aggrecan were detected by reverse transcription‑quantitative polymerase chain reaction (RT-qPCR). 29207013

2018

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 GeneticVariation BEFREE A systematic review of the relationship between the distributions of aggrecan gene VNTR polymorphism and degenerative disc disease/osteoarthritis.<i>Bone Joint Res</i> 2018;7:308-317. 29922449

2018

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 AlteredExpression BEFREE Histology and immunostaining revealed that disc degeneration was not significantly different between the OVX + NS rats and the OVX + PTH rats, compared with the Sham group; the structure of nucleus pulposus was disordered, the expression of collagen I was increased, and collagen II and aggrecan were decreased. 29442158

2018

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 Biomarker BEFREE The stable expression of <i>CTGF</i> and <i>TIMP1</i> genes <i>in vivo</i> promoted the synthesis of aggrecan and type II collagen in the nucleus pulposus in the rhesus monkey model of intervertebral disc degeneration, which has a potential for intervertebral disc regeneration. 29736202

2018

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 AlteredExpression BEFREE Therefore, our study shows that HIF-1α regulates collagen Π and aggrecan expression through NOTCH1 signaling and implicate NOTCH1 as a potential therapeutic target in disc degeneration. 28526405

2017

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 GeneticVariation BEFREE Our study provides evidence that COL2A1 and Aggrecan genetic polymorphisms may be correlated with the risk and clinicopathological features of IVDD in a Chinese Han population, and ACGL and GTCL haplotypes may be protective factors of IVDD. 27991836

2017

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 GeneticVariation BEFREE Genetic polymorphisms in 20 genes have been analyzed in association with DD, including vitamin D receptor, growth differentiation factor 5 (GDF5), aggrecan, collagen Types I, IX, and XI, fibronectin, hyaluronan and proteoglycan link protein 1 (HAPLN1), thrombospondin, cartilage intermediate layer protein (CILP), asporin, MMP1, 2, and 3, parkinson protein 2, E3 ubiquitin protein ligase (PARK2), proteosome subunit β type 9 (PSMB9), tissue inhibitor of metalloproteinase (TIMP), cyclooxygenase-2 (COX2), and IL1α, IL1β, and IL6. 23537453

2013

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 GeneticVariation BEFREE Vitamin D receptor gene and aggrecan gene polymorphisms and the risk of intervertebral disc degeneration - a meta-analysis. 23209686

2012

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 Biomarker BEFREE Intervertebral disc degeneration (IDD) pertains to the loss of extracellular matrix (ECM), particularly the early loss of aggrecan, the turnover of which is regulated by ADAMTSs. 21809381

2012

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 GeneticVariation BEFREE Significant associations were found between short repeated alleles of the aggrecan gene and severe disc degeneration. 21948754

2011

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 GeneticVariation BEFREE We wanted to investigate the patterns of the variable numbers of tandem repeat polymorphism in the aggrecan CS1 domain of Koreans, and we analyzed the association between the polymorphism and intervertebral disc degeneration. 20936487

2011

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 AlteredExpression BEFREE Variations in aggrecan localization and gene expression patterns characterize increasing stages of human intervertebral disk degeneration. 21689646

2011

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 GeneticVariation BEFREE Aggrecan fragments have been found in human degenerated discs, and an association between the aggrecan VNTR polymorphism and intervertebral disc degeneration has been previously reported in middle-aged Finnish men. 20505571

2010

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 GeneticVariation BEFREE Our data suggest that carrying shorter AGC1 alleles with less than 24 repeats could predispose a subject to lumbar disk degeneration disease in northern Iran. 20496110

2010

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 GeneticVariation BEFREE However, the interaction between aggrecan gene VNTR polymorphism and smoking in symptomatic intervertebral disc degeneration (IDD) has not been well studied. 20367118

2010

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 GeneticVariation BEFREE This study revealed that the polymorphisms of the VDR and aggrecan genes are associated with disc degeneration and herniation. 20367178

2010

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 Biomarker BEFREE Intervertebral disc degeneration is linked to loss of extracellular matrix (ECM), particularly the early loss of aggrecan. 19180493

2009

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 GeneticVariation BEFREE An association between the aggrecan VNTR polymorphism and multilevel disc degeneration has been previously reported in young Japanese women. 17632389

2007

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 Biomarker BEFREE To determine the expression of ADAMTS-4, a metalloproteinase capable of digesting aggrecan, and its role in herniated lumbar intervertebral disc degradation. 16741450

2006

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 GeneticVariation BEFREE Tryptophan alleles in COL9A2 and COL9A3 have been shown to be associated with lumbar disc disease in the Finnish population, and polymorphisms in the vitamin D receptor gene (VDR) (FokI and TaqI), the matrix metalloproteinase-3 gene (MMP-3) and an aggrecan gene (AGC1) VNTR have been reported to be associated with disc degeneration. 14644861

2003

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 Biomarker BEFREE In degeneration, there was evidence of a loss of aggrecan synthesis, which may contribute to the pathogenesis of disc degeneration. 11950957

2002