Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.060 Biomarker BEFREE Mesenchymal stem cells deliver exogenous miR-21 via exosomes to inhibit nucleus pulposus cell apoptosis and reduce intervertebral disc degeneration. 28805297

2018

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.060 AlteredExpression BEFREE Following qRT-PCR validation, miR-21 expression was significantly upregulated in degenerated NP tissues, and showed a positive correlation with disc degeneration grade. 29710470

2018

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.060 Biomarker BEFREE A rat model of intervertebral disc degeneration was established and miR-21 inhibitor (antagomiR-21) was administered. 29896228

2018

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.060 Biomarker BEFREE Mechanism of microRNA-21 regulating IL-6 inflammatory response and cell autophagy in intervertebral disc degeneration. 28810608

2017

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.060 AlteredExpression BEFREE NP tissues were collected from 20 intervertebral disc degeneration (IDD) patients, and from 5 patients with traumatic spine fracture.MiR-21 expressions were tested. 27240294

2016

Entrez Id: 406991
Gene Symbol: MIR21
MIR21
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.060 Biomarker BEFREE Our study also underscores the potential of miR-21 and the PTEN/Akt pathway as novel therapeutic targets in intervertebral disc degeneration. 24603539

2014