Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.360 Biomarker BEFREE This study suggests that TGF-β1 may be effective to retard inflammation-mediated disc degeneration. 31808511

2020

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.360 GeneticVariation BEFREE Association of IL10 and TGFB single nucleotide polymorphisms with intervertebral disc degeneration in Iranian population: a case control study. 29636026

2018

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.360 Biomarker BEFREE In conclusion, we demonstrate the potential of TGFβ1 and CTGF to mitigate the progression of disc degeneration and the potential use of these molecules in a molecular therapy to treat the degenerative disc. 28358123

2017

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.360 Biomarker BEFREE In vivo, TGF-β1 injection inhibited the development of degenerative features in the IVDD model. 28935976

2017

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.360 Biomarker BEFREE We explored the feasibility of reversing intervertebral disc degeneration using human vascular endothelial growth factor165 (hVEGF165) and transforming growth factor-β1 (TGF-β1) gene therapy. hVEGF165 complementary DNA was obtained from pcDNA3(+)-hVEGF165 and cloned into adeno-associated virus (AAV)-pSNAV plasmids to construct the recombinant plasmid, AAV-pSNAV-hVEGF165. 23479156

2013

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.360 Therapeutic CTD_human The in vitro effects of dexamethasone, insulin and triiodothyronine on degenerative human intervertebral disc cells under normoxic and hypoxic conditions. 21351055

2011

Entrez Id: 7040
Gene Symbol: TGFB1
TGFB1
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.360 Biomarker BEFREE Since it is known that TGF-beta1 induces matrix alterations (by auto and paracrine stimulation of matrix synthesis), these observations suggest that the recently described disturbance of the matrix during disc degeneration may be induced by TGF-beta. 15340826

2005

Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.330 Biomarker BEFREE 7-9-month old wild-type and secreted protein acidic and rich in cysteine (SPARC)-null (a model of disc degeneration and LBP) male mice were treated with TAK-242 (TLR4 inhibitor) once, and following a 10-day washout, mice were treated 3 times/week for 8 weeks. 29908959

2018

Entrez Id: 5654
Gene Symbol: HTRA1
HTRA1
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.330 Biomarker BEFREE CONCLUSIONS The expression of HtrA1 was strongly related to the T2 value, suggesting that HtrA1 plays an important role in the pathological process of intervertebral disc degeneration. 28432852

2017

Entrez Id: 5654
Gene Symbol: HTRA1
HTRA1
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.330 Biomarker GENOMICS_ENGLAND Heterozygous HTRA1 mutations are associated with autosomal dominant cerebral small vessel disease. 26063658

2015

Entrez Id: 5654
Gene Symbol: HTRA1
HTRA1
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.330 Biomarker BEFREE In vitro study to develop an intervertebral disc degeneration organ culture model, using coccygeal bovine intervertebral discs (IVDs) and injection of proteolytic enzymes MMP-3, ADAMTS-4, and HTRA1. 23778376

2013

Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.330 GeneticVariation BEFREE Inactivation of the SPARC gene in mice results in premature intervertebral disc degeneration. 20714283

2011

Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.330 PosttranslationalModification BEFREE In parallel, we show that human subjects with back pain exhibit signs of disc degeneration and increased methylation of the SPARC promoter. 21867537

2011

Entrez Id: 6678
Gene Symbol: SPARC
SPARC
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.330 Biomarker CTD_human Inactivation of the SPARC gene in mice results in premature intervertebral disc degeneration. 20714283

2011

Entrez Id: 5654
Gene Symbol: HTRA1
HTRA1
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.330 GeneticVariation BEFREE A genetic variation at the HTRA1 gene promoter locus is associated with spinal disc degeneration, suggesting an involvement of the HTRA1 gene in osteoarthritis. 19798546

2010

Entrez Id: 4088
Gene Symbol: SMAD3
SMAD3
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.120 GeneticVariation BEFREE At the SMAD3 gene, SNP rs422342 was also found to be statistically associated (p-value .0282) to intervertebral disc degeneration (permutation p-value .042). 28662992

2017

Entrez Id: 4088
Gene Symbol: SMAD3
SMAD3
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.120 AlteredExpression BEFREE Together these studies suggest that TGFβ, through Smad3 controls Galectin-3 expression in NP cells and may have implications in the intervertebral disc degeneration. 26639428

2016

Entrez Id: 4088
Gene Symbol: SMAD3
SMAD3
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.120 Biomarker HPO

Entrez Id: 4000
Gene Symbol: LMNA
LMNA
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.110 AlteredExpression BEFREE Western blot was performed to evaluate lamin A/C expression in IVD tissues. 30536301

2018

Entrez Id: 4000
Gene Symbol: LMNA
LMNA
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.110 Biomarker HPO

Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 GeneticVariation BEFREE Association of vitamin D receptor gene polymorphisms with disc degeneration. 31768839

2020

Entrez Id: 7124
Gene Symbol: TNF
TNF
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 Biomarker BEFREE Apoptosis in nucleus pulposus (NP) cells which induced by TNF-α has been widely known to associate with the disc degeneration. 31322007

2019

Entrez Id: 176
Gene Symbol: ACAN
ACAN
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 Biomarker BEFREE Within this scope, we discuss the current knowledge concerning the structure and function of aggrecan in intervertebral disc degeneration. 29992840

2019

Entrez Id: 3553
Gene Symbol: IL1B
IL1B
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 Biomarker BEFREE To investigate the role of IL-1 in driving age-related disc degeneration, we studied the spine phenotype of global IL-1α/β double knockout (IL-1KO) mice at 12 and 20 months. 30875127

2019

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0158266
Disease: Intervertebral Disc Degeneration
Intervertebral Disc Degeneration
0.100 Biomarker BEFREE IL-6/YAP1/β-catenin signaling is involved in intervertebral disc degeneration. 30511395

2019