Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE The androgen receptor is a transcription factor activated by the testosterone metabolite 5α-dihydrotestosterone and regulates the expression of genes related to sexual differentiation, growth and survival of prostate cells, and to a certain extent, cancer progression. 31712062

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE These ΔLBD androgen receptor variants have shown the capability to induce androgen receptor-mediated gene transcription even under conditions of androgen deprivation and to drive cancer progression. 30659302

2020

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE A key mechanism of treatment resistance in advanced PC is the generation of alternatively spliced forms of the AR termed AR variants (AR-Vs) that are refractory to targeted agents and drive tumour progression. 31006810

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE We have previously reported that deubiquitinase USP14 stabilizes AR proteins by deubiquitination and USP14 inhibition results in inhibition of cell growth and tumor progression in AR-positive prostate cancer and breast cancer. 31126320

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Importantly, TGF-β signaling and microRNA-mediated regulation of gene expression often act in complicated feedback circuits that involve other crucial regulators of cancer progression (e.g., androgen receptor). 31842336

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE CONCLUSIONS The present results suggest that targeting of PLCε/BMP-6/SMAD signaling may increase the sensitivity of CRPC to AR antagonists and inhibit tumor progression. 31201297

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE Whether the AR gene also transcribes non-coding circular RNAs that are associated with PCa development and tumor progression remains unclear. 31760376

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE While BHC80-2 does not induce neuroendocrine differentiation of cancer cells, it stimulates cell proliferation and tumor progression independent of androgen receptor signaling. 30910347

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Collectively, these data credential CHD1 as a tumor suppressor in the prostate that constrains AR binding/function to limit tumor progression. 30930119

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The androgen receptor (AR) is tightly linked to prostate cancer, but the mechanisms by which AR transactivation is dysregulated during cancer progression are not fully explored. 31152093

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Specifically, androgen receptor activation appears to be associated with increased risks of developing ovarian cancer and inducing tumor progression. 30791431

2019

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Changes in androgen receptor signaling from androgen deprivation therapy have been linked to therapeutic resistance and tumor progression. 29345000

2018

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Nuclear Factor-κB Promotes Urothelial Tumorigenesis and Cancer Progression via Cooperation with Androgen Receptor Signaling. 29592878

2018

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 GeneticVariation BEFREE This study demonstrated a possible interaction of gene (AR-Q polymorphism) and environmental toxins (e.g.BaP) to affect cancer progression. 28782227

2018

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE The androgen receptor (AR) is the classical target for prostate cancer prevention and treatment, but more recently estrogens and their receptors have also been implicated in prostate cancer development and tumor progression. 29094395

2018

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE However, the biological action of AR in these cells and its effect on cancer progression remains to be fully understood. 29618577

2018

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Taken together, we hypothesize that IL-1 reprograms AR positive (AR<sup>+</sup> ) PCa cells into AR negative (AR<sup>-</sup> ) PCa cells that co-opt IL-1 signaling to ensure AR-independent survival and tumor progression in the inflammatory tumor microenvironment. 29527701

2018

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 AlteredExpression BEFREE We filtered this module by identifying genes that functionally interacted with AR variants using a high-throughput synthetic genetic array screen in <i>Schizosaccharomyces pombe</i> This strategy identified seven AR variant-regulated genes that also enhance AR activity and drive cancer progression. 30108134

2018

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE However, steroidal drugs with a 3β-hydroxyl, Δ<sup>5</sup>-structure, such as abiraterone, are also metabolized by 3β-HSD1, and 5α-abiraterone, a downstream metabolite, has been shown to activate the androgen receptor, potentially driving cancer progression. 29231195

2018

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Notably, emerging preclinical evidence has indicated the involvement of androgen receptor (AR) signaling in urothelial cancer progression. 29720561

2018

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Here we report evidence to show that AR is a key mediator of inflammatory signals in ESCC cancer progression. 27801498

2017

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Co-amplification of the Golgi protein coding YIPF6 gene with the AR may enhance the secretion of pro-coagulative EVs from cancer cells and thereby stimulate tumor progression and increase the coagulopathy risk in CRPC patients.Prostate 77: 625-638, 2017. 28144969

2017

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Galectin-3 Is Implicated in Tumor Progression and Resistance to Anti-androgen Drug Through Regulation of Androgen Receptor Signaling in Prostate Cancer. 28011482

2017

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Inverse correlations detected between tumor grade and AR/androgen metabolizing enzyme also suggested that the loss of AR and androgen-producing enzymes could be associated with tumor progression. 28947209

2017

Entrez Id: 367
Gene Symbol: AR
AR
CUI: C0178874
Disease: Tumor Progression
Tumor Progression
0.100 Biomarker BEFREE Androgen receptor plays a pivotal role in prostate cancer progression, and androgen deprivation therapy to intercept androgen receptor signal pathway is an indispensable treatment for most advanced prostate cancer patients to delay cancer progression. 28475016

2017