Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE CHRNA5/CHRNA3/CHRNB4 gene cluster is located on chromosome 15q25.1 and was reported to be associated with risk of lung cancer. 29416783

2018

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 Biomarker BEFREE Polymorphisms in CHRNA3, CHRNA5, and CHRNB4 receptors play a critical role in nicotine dependence, lung cancer (LC) risk, and chronic obstructive pulmonary disease (COPD). 29993116

2018

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Using a case-control study, we decided to investigate the associations between CHRNA3 rs6495308, CHRNB4 rs11072768, smoking behaviors and lung cancer risk, as well as explore whether the two SNPs have a direct or indirect carcinogenic effect on lung cancer. 26942719

2016

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Genetic variation in the cluster on chromosome 15, encoding the nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4), has shown strong associations with tobacco consumption and an additional risk increase in smoking-related diseases such as chronic obstructive pulmonary disease (COPD), peripheral artery disease and lung cancer. 26689306

2016

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 Biomarker BEFREE Single-nucleotide polymorphisms (SNPs) in the cholinergic nicotinic receptor subunit genes on chromosome 15q25.1, including CHRNA3, CHRNB4 and CHRNA5, are well-established biomarkers of chronic obstructive pulmonary disease (COPD) and lung cancer. 27462996

2016

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Because the associations with lung disease remain after adjustment for self-reported smoking behaviors, it has been asserted that CHRNA5-CHRNA3-CHRNB4 variants increase COPD and lung cancer susceptibility independently of their effects on smoking. 25072098

2014

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 Biomarker BEFREE Previously we found that variation in CYP2A6 and CHRNA5-CHRNA3-CHRNB4 combined to increase lung cancer risk in a case-control study in European American ever-smokers (n = 860). 23591849

2013

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Neuronal nicotinic acetylcholine receptor (nAChR) genes (CHRNA5/CHRNA3/CHRNB4) have been reproducibly associated with nicotine dependence, smoking behaviors, and lung cancer risk. 24186853

2013

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Indeed, genetic variation in the CHRNA5-CHRNA3-CHRNB4 gene cluster, encoding the α5, α3, and β4 nAChR subunits, respectively, has been shown to increase vulnerability to tobacco dependence and smoking-associated diseases including lung cancer. 23143843

2013

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Nicotinic acetylcholine receptor alpha3, alpha5 and beta4 genes (CHRNA3, CHRNA5 and CHRNB4) cluster at the 15q25.1 lung cancer susceptibility locus. 23011884

2013

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Single-nucleotide polymorphisms rs421629 on 5p15.33 and rs1948, rs660652, rs8040868 and rs2036527 on 15q25.1, previously identified as lung cancer risk or nicotine-addiction modifiers, were associated with tumor DNA methylation levels in the promoters of TERT and CHRNB4 (P<0.001), respectively, in two independent sample sets (n=82; n=150). 22945651

2013

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation GWASDB Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls. 22899653

2012

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Scope of Proposed Topic (50 words): Genome-wide association (GWA) studies both in lung cancer and COPD highlighted the same variants (SNPs) on the gene cluster CHRNA3-CHRNB4-CHRNA5. 23061658

2012

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Several genome-wide association and candidate gene studies have linked chromosome 15q24-q25.1 (a region including the CHRNA5-CHRNA3-CHRNB4 gene cluster) with alcohol dependence, nicotine dependence and smoking-related illnesses such as lung cancer and chronic obstructive pulmonary disease. 22438940

2012

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 Biomarker BEFREE The CHRNA5-CHRNA3-CHRNB4 gene cluster on 15q25 has consistently been associated with smoking quantity, nicotine dependence and lung cancer. 23029550

2012

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Previous studies revealed association of lung cancer risk with single nucleotide polymorphisms (SNPs) in chromosome 15q25 region containing CHRNA5-CHRNA3-CHRNB4 nicotinic acetylcholine receptor (nAChR) subunit gene cluster. 22280835

2012

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE In a nested case-control study comparing 746 lung cancer cases to 1,477 controls, all of whom were non-Hispanic white smokers in the β-Carotene and Retinol Efficacy Trial, we examined whether lung cancer risk is associated with single nucleotide polymorphisms (SNPs) tagging the AGPHD1, CHRNA5, CHRNA3, and CHRNB4 genes and whether such risk is modified by diet and other characteristics. 21229299

2011

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk. 21747048

2011

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 Biomarker BEFREE Because studying African American persons, who exhibit lower levels of linkage disequilibrium in this region, may identify additional loci that are associated with lung cancer, we genotyped 34 single-nucleotide polymorphisms (SNPs) in this region (including LOC123688, PSMA4, CHRNA5, CHRNA3, and CHRNB4 genes) in 467 African American patients with lung cancer and 388 frequency-matched African American control subjects. 20554942

2010

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE CHRNA5 rs17486278 G had OR = 1.28, 95% CI 1.07-1.54 and P = 0.008, whereas CHRNB4 rs7178270 G had OR = 0.78, 95% CI 0.66-0.94 and P = 0.008 for lung cancer risk. 20587604

2010

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Genetic association studies have shown the importance of variants in the CHRNA5-CHRNA3-CHRNB4 cholinergic nicotinic receptor subunit gene cluster on chromosome 15q24-25.1 for the risk of nicotine dependence, smoking, and lung cancer in populations of European descent. 19706762

2009

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation GWASDB Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study. 19654303

2009

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Nicotine dependence risk and lung cancer risk are associated with variants in a region of chromosome 15 encompassing genes encoding the nicotinic receptor subunits CHRNA5, CHRNA3 and CHRNB4. 19443489

2009

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation GWASDB Common 5p15.33 and 6p21.33 variants influence lung cancer risk. 18978787

2008

Entrez Id: 1143
Gene Symbol: CHRNB4
CHRNB4
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 Biomarker BEFREE We identified associations between common sequence variants at 15q24-25.1 (that spanned LOC123688 [a hypothetical gene], PSMA4, CHRNA3, CHRNA5, and CHRNB4) and lung cancer. 18780872

2008