Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 Biomarker BEFREE Of the pure GGOs, 9 (25%) nodules were classified as AIS, 10 (27.8%) nodules were classified as MIA and 22 (57.9%) of the mGGOs were lung cancer. 31426812

2019

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 Biomarker BEFREE TTF-1 and napsin A for lung adenocarcinoma, p40 for squamous lung cancer, GATA3 and mammaglobin for breast cancer, or synaptophysin and chromogranin A for neuroendocrine tumors). 30354850

2019

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 Biomarker BEFREE However, morphology and TTF-1 and p40 IHC staining is sufficient for correct diagnosis in most non-small cell lung cancers. 30718697

2019

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 Biomarker BEFREE Kaplan-Meier analysis showed that only tumor invasion status (IAD vs AIS/MIA, p = 0.003) could predict 5-year lung cancer-specific overall survival (LCS-OS), and IAD had a worse LCS-OS than AIS and MIA. 30096292

2018

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Among them, TP63 (3q28), RP11-650L12.2 (15q25.1) and CHRNA5 (15q25.1) were located in known lung cancer susceptibility loci. 29193083

2018

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE These results suggest that TP63 rs7631358 G > A and CSF1R rs10079250 A > G may affect the prognosis of NSCLC in never-smoking females, as well as the risk of lung cancer. 28449811

2017

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Two single nucleotide polymorphisms (SNPs), rs6790167 (g243059A>G) in intron 9 of TP63 and rs1535045 (g6194C>T) in intron 1 of CD40 respectively, may affect the susceptibility of lung cancer. 27063419

2016

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 Biomarker BEFREE To improve segregation between ADC and SqCC in small samples, the classification of lung cancer was updated in 2011, adding immunohistochemistry (IHC) for p63 and TTF-1 to the diagnostic algorithm. 25982011

2015

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Our observations provide evidence that genetic variation in HLA Class II and TP63 may modify the association between HAP and lung cancer risk. 25566987

2015

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Quantitative assessment of the influence of TP63 gene polymorphisms and lung cancer risk: evidence based on 93,751 subjects. 24466311

2014

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation GWASDB Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer. 24880342

2014

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Our results, combined with those from previous studies, suggest that genetic variation in TP63 may influence lung cancer susceptibility in the Han population. 24092572

2014

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE Among 16 SNPs, three SNPs (colony-stimulating factor 1 receptor [CSF1R] rs10079250A>G, tumor protein p63 [TP63] rs7631358G>A, and corepressor interacting with RBPJ 1 [CIR1] rs13009079T>C) were found to be significantly associated with lung cancer in the same direction as the discovery set. 25144241

2014

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation GWASDB Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. 23143601

2012

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 Biomarker BEFREE This minimalist IHC-based model of p40 and TTF1 on biopsy/cellblock samples was effective to correctly subtype most cases of lung cancer. 22071786

2012

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 AlteredExpression BEFREE Although p63 and its isoforms are overexpressed in a wide variety of human malignancies such as cervical, head and neck, and lung cancer, their role in endometrial carcinoma has not been investigated. 22441934

2012

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE To determine if this association with lung cancer risk is independent of tobacco use, we genotyped the TP63 SNPs reported by the previous GWAS (rs10937405 and rs4488809) in 3,467 never-smoking female lung cancer cases and 3,787 never-smoking female controls from 10 studies conducted in Taiwan, Mainland China, South Korea, and Singapore. 22367405

2012

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation GWASDB The combined analyses identified six well-replicated SNPs with independent effects and significant lung cancer associations (P < 5.0 × 10(-8)) located in TP63 (rs4488809 at 3q28, P = 7.2 × 10(-26)), TERT-CLPTM1L (rs465498 and rs2736100 at 5p15.33, P = 1.2 × 10(-20) and P = 1.0 × 10(-27), respectively), MIPEP-TNFRSF19 (rs753955 at 13q12.12, P = 1.5 × 10(-12)) and MTMR3-HORMAD2-LIF (rs17728461 and rs36600 at 22q12.2, P = 1.1 × 10(-11) and P = 6.2 × 10(-13), respectively). 21725308

2011

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 Biomarker CTD_human The combined analyses identified six well-replicated SNPs with independent effects and significant lung cancer associations (P < 5.0 × 10(-8)) located in TP63 (rs4488809 at 3q28, P = 7.2 × 10(-26)), TERT-CLPTM1L (rs465498 and rs2736100 at 5p15.33, P = 1.2 × 10(-20) and P = 1.0 × 10(-27), respectively), MIPEP-TNFRSF19 (rs753955 at 13q12.12, P = 1.5 × 10(-12)) and MTMR3-HORMAD2-LIF (rs17728461 and rs36600 at 22q12.2, P = 1.1 × 10(-11) and P = 6.2 × 10(-13), respectively). 21725308

2011

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE The combined analyses identified six well-replicated SNPs with independent effects and significant lung cancer associations (P < 5.0 × 10(-8)) located in TP63 (rs4488809 at 3q28, P = 7.2 × 10(-26)), TERT-CLPTM1L (rs465498 and rs2736100 at 5p15.33, P = 1.2 × 10(-20) and P = 1.0 × 10(-27), respectively), MIPEP-TNFRSF19 (rs753955 at 13q12.12, P = 1.5 × 10(-12)) and MTMR3-HORMAD2-LIF (rs17728461 and rs36600 at 22q12.2, P = 1.1 × 10(-11) and P = 6.2 × 10(-13), respectively). 21725308

2011

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 GeneticVariation BEFREE A common set of genes dysregulated in lung cancer was obtained, including BPA1, DUSP6, ASCL1, RNAS1 and S100P. p63 and CK 5/6 p63 are useful for differentiating adenocarcinoma and small cell lung cancer from squamous cell carcinoma. 20332665

2010

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 Biomarker CTD_human Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations. 20871597

2010

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 Biomarker BEFREE Here, we tested whether genomic gains in six specific loci, TP63 on 3q28, EGFR on 7p12, MYC on 8q24, 5p15.2, and centromeric regions for chromosomes 3 (CEP3) and 6 (CEP6), may provide further value in the prediction of lung cancer. 19547694

2009

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 AlteredExpression BEFREE Transient expression of p63 transactivated the maspin promoter with remarkable fold changes in cells expressing the TAp63, suggesting that TAp63 might be a novel stimulator of the maspin promoter in lung cancer. 15466179

2004

Entrez Id: 8626
Gene Symbol: TP63
TP63
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.500 Biomarker BEFREE These observations suggest that p63 genomic amplification has an early role in lung tumorigenesis and deserves additional evaluation as a biomarker for lung cancer progression. 14612504

2003