Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.350 AlteredExpression BEFREE Peripheral blood mononuclear cells (PBMCs) from 25 patients with chronic periodontitis (CP) and 25 healthy individuals were assayed for cluster of differentiation14<sup>+</sup> (CD14<sup>+</sup> ) expression and monocytes were induced to differentiate into osteoclasts for 21 days in-vitro in the presence of macrophage colony stimulating factor (M-CSF) and receptor activator of nuclear factor-kappa B ligand (RANKL). 29958327

2019

Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.350 GeneticVariation BEFREE Comparison of genotype expression of SNP rs9533156 on RANKL gene between the peri-implantitis group with chronic periodontitis and control groups revealed statistically significant differences (P=0.001); the prevalence of CT genotype was significantly higher amongst the chronic periodontitis group. 23177932

2013

Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.350 Biomarker CTD_human Reduced expression of lipopolysaccharide-induced CXC chemokine in Porphyromonas gingivalis-induced experimental periodontitis in matrix metalloproteinase-8 null mice. 20731768

2011

Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.350 AlteredExpression BEFREE The expression of RANKL as well as of OPG was reduced in CP specimens in comparison to that of healthy persons in a statistical significant way. 20033478

2010

Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.350 Biomarker BEFREE Over-expression of forkhead box P3 and its association with receptor activator of nuclear factor-kappa B ligand, interleukin (IL) -17, IL-10 and transforming growth factor-beta during the progression of chronic periodontitis. 19419438

2009

Entrez Id: 8600
Gene Symbol: TNFSF11
TNFSF11
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.350 AlteredExpression LHGDN Saliva concentrations of RANKL and osteoprotegerin in smoker versus non-smoker chronic periodontitis patients. 18727653

2008

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.300 Biomarker BEFREE The findings of gender disparity in the DNAm of MMP-9 and TIMP-1 genes provide novel insights into chronic periodontitis. 29298087

2018

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.300 Therapeutic RGD To investigate the effect of periodontal mechanical treatment on serum interleukin-6 (IL-6) and carotid artery matrix metalloproteinase (MMP)-2 and MMP-9 expression in chronic periodontitis (CP) SD rats with atherosclerosis (As). 24820783

2014

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.300 GeneticVariation BEFREE We found MMP-9 -1562C>T contributed to decreased risk of chronic periodontitis. 23252412

2013

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.300 GeneticVariation BEFREE MMP-1-1067 2G, MMP-3-1171 6A, MMP-9-1562 T and IL-8-251 A allele are associated with decreased susceptibility to CP in Chinese population. 22819245

2012

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.300 GeneticVariation BEFREE Association of matrix metalloproteinase (MMP-1, MMP-3 and MMP-9) and cyclooxygenase-2 gene polymorphisms and their proteins with chronic periodontitis. 21481333

2011

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.300 AlteredExpression BEFREE The association between salivary levels of MMP-9, TIMP-1 and MMP-9/TIMP-1 ratio with CP was assessed individually and adjusted for confounding using a binary logistic regression model. 21094936

2011

Entrez Id: 6387
Gene Symbol: CXCL12
CXCL12
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.300 Biomarker CTD_human Reduced expression of lipopolysaccharide-induced CXC chemokine in Porphyromonas gingivalis-induced experimental periodontitis in matrix metalloproteinase-8 null mice. 20731768

2011

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.300 AlteredExpression LHGDN The short-term effectiveness of non-surgical treatment in reducing levels of interleukin-1beta and proteases in gingival crevicular fluid from patients with type 2 diabetes mellitus and chronic periodontitis. 18980523

2008

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.300 GeneticVariation BEFREE The aim of this study was to investigate MMP-2, MMP-9 and MMP-12 gene polymorphisms in relation to susceptibility to severe chronic periodontitis (CP). 18155181

2008

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.300 GeneticVariation BEFREE Association of matrix metalloproteinase-9 promoter gene polymorphism with chronic periodontitis. 16945027

2006

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.300 GeneticVariation LHGDN MMP-9 promoter gene polymorphism seems to be associated with severe generalized chronic periodontitis. 16945027

2006

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.300 GeneticVariation BEFREE These findings suggest that genetic polymorphisms of the MMP-9 gene are not associated with the susceptibility to CP in the Czech population; however, the promoter variant may influence the severity of the disease in men. 17076610

2006

Entrez Id: 4318
Gene Symbol: MMP9
MMP9
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.300 GeneticVariation BEFREE No association was observed between the polymorphism in the promoter region of MMP-9 (p=0.6693) and chronic periodontitis. 15691353

2005

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.230 Biomarker BEFREE A significant association among the production of MMP-2/TIMP-2 complex with the presence of CP (P = 0.008) and periodontal parameters PD, CAL, and BOP was identified. 28492359

2017

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.230 Therapeutic RGD [Influence of periodontal therapy on serum interleukin-6 and carotid metalloproteinases in animals with chronic periodontitis associated with atherosclerosis]. 24820783

2014

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.230 GeneticVariation BEFREE Differences between rare allele carriage rates of CP and healthy groups regarding MMP-2, MMP-9 and MMP-12 gene polymorphisms were not significant (p>0.05). 18155181

2008

Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.230 GeneticVariation BEFREE Genetic variations in the human gelatinase A (matrix metalloproteinase-2) promoter are not associated with susceptibility to, and severity of, chronic periodontitis. 16018746

2005

Entrez Id: 3552
Gene Symbol: IL1A
IL1A
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.100 GeneticVariation BEFREE IL-1A (-889C/T) polymorphism is associated with the susceptibility of chronic periodontitis in African, European and American populations according to the currently available evidence. 31759990

2020

Entrez Id: 3552
Gene Symbol: IL1A
IL1A
CUI: C0266929
Disease: Chronic Periodontitis
Chronic Periodontitis
0.100 GeneticVariation BEFREE The association between IL1A -889 and IL1B +3954 polymorphisms and chronic periodontitis is questionable due to methodological inconsistency. 30982982

2019